Results 101 to 110 of about 37,475 (253)

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. [PDF]

, 2017
Glutamate is the dominant excitatory neurotransmitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels.
Andreyev, Alexander Y, Bloodgood, Brenda L, Buren, Caodu, Cordes, Thekla, Divakaruni, Ajit S, Fields, Jerel A, Li, Edward, Martyniuk, Kelly, Metallo, Christian M, Murphy, Anne N, Raymond, Lynn A, Reynolds, Ian J, Wallace, Martina   +12 more
core   +1 more source

Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD

Journal of Neuroinflammation
There is an intrinsic relationship between psychiatric disorders and neuroinflammation, including bipolar disorder. Ouabain, an inhibitor of Na+/K+-ATPase, has been implicated in the mouse model with manic-like behavior. However, the molecular mechanisms
Tzu-Yun Wang, Eddie Feng-Ju Weng, Yun-Chen Hsu, Lu-Ping Shiu, Teng-Wei Huang, Hsuan-Cheng Wu, Jau-Shyong Hong, Shao-Ming Wang   +7 more
doaj   +1 more source

Na+, K+-ATPase inhibition induces neuronal cell death in rat hippocampal slice cultures: Association with GLAST and glial cell abnormalities

Journal of Pharmacological Sciences, 2018
Na+, K+-ATPase is a highly expressed membrane protein. Dysfunction of Na+, K+-ATPase has been implicated in the pathophysiology of several neurodegenerative and psychiatric disorders, however, the underlying mechanism of neuronal cell death resulting ...
Yuki Kurauchi, Kazuki Noma, Akinori Hisatsune, Takahiro Seki, Hiroshi Katsuki   +4 more
doaj   +1 more source

Cleavage of endogenous gamma ENaC and elevated abundance of alpha ENaC are associated with increased Na+ transport in response to apical fluid volume expansion in human H441 airway epithelial cells [PDF]

, 2011
Using human H441 airway epithelial cells cultured at air–liquid interface (ALI), we have uniquely correlated the functional response to apical fluid volume expansion with the abundance and cleavage of endogenous α- and γENaC proteins in the apical ...
Baines, DL, Selvanathar, IA, Tan, CD
core   +2 more sources

Changes of intracellular sodium and potassium ion concentrations in frog spinal motoneurons induced by repetitive synaptic stimulation [PDF]

, 1982
A post-tetanic membrane hyperpolarization following repetitive neuronal activity is a commonly observed phenomenon in the isolated frog spinal cord as well as in neurons of other nervous tissues.
Baker, Baylor, Bu¨hrle, Coles, Cordingley, Czeh, Davidoff, G. ten Bruggencate, Grafe, Gu¨ggi, Heinemann, Hofmeier, J. Rimpel, Krnjevic, Kuno, Kuramoto, Lux, M.M. Reddy, Mori, Nakajima, Nicholson, Nicoll, O'Doherty, P. Grafe, Ritchie, Smith, Sonnhof, Sonnhof, Sonnhof, Steiner, Sykova, Tang, Thomas, Vern   +33 more
core   +1 more source

Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund.Background: Radial chromosome positioning in interphase nuclei is nonrandom and can alter according to developmental, differentiation, proliferation, or disease status.
Amira, M, Bridger, JM, Harvey, AJ, Mehta, IS   +3 more
core   +2 more sources

Role of endogenous ouabain in the etiology of bipolar disorder [PDF]

, 2021
Rif S. El‐Mallakh, Yonglin Gao, Pan You   +2 more
openalex   +1 more source

Involvement of Inflammatory Cytokines in Antiarrhythmic Effects of Clofibrate in Ouabain-Induced Arrhythmia in Isolated Rat Atria

Advances in Pharmacological Sciences, 2016
Considering the cardioprotective and anti-inflammatory properties of clofibrate, the aim of the present experiment was to investigate the involvement of local and systemic inflammatory cytokines in possible antiarrhythmic effects of clofibrate in ouabain-
Somayeh Moradi, Vahid Nikoui, Muhammad Imran Khan, Shayan Amiri, Farahnaz Jazaeri, Azam Bakhtiarian   +5 more
doaj   +1 more source

Mechanism of NaCl transport-stimulated prostaglandin formation in MDCK cells [PDF]

, 1987
Recently we have found that stimulation of NaCl transport in high-resistance MDCK cells enhances their prostaglandin formation. In the present study, we investigated the mechanisms by which prostaglandin formation could be linked to the ion transport in ...
Bauer, C., Kurtz, Armin, Malmström, K., Pfeilschifter, J., Woodson, R. D.   +4 more
core   +1 more source

Role of Ca2+-activated K+ channels and Na+-K+-ATPase in prostaglandin E1- and E2-induced inhibition of the adrenergic response in human vas deferens [PDF]

, 2011
We studied the role of K+ channels and Na+,K+-ATPase in the presynaptic inhibitory effects of prostaglandin E1 (PGE1) and PGE2 on the adrenergic responses of human vas deferens.
Banchelli, Benham, Birmingham, Blatz, Brugnara, Docherty, Edwards, Galvez, Gloria Segarra, Glynn, Gordon, Hedlund, Hedqvist, Herman, Holmquist, Huang, Illes, José M. Vila, Kaczorowski, Kanwal, Legler, Liang, Malik, María Dolores Mauricio, McKay, Medina, Medina, Medina, Miller, Miller, Miller, Nakazato, North, Pascual Chuan, Pascual Medina, Ruan, Salvador Lluch, Sanbe, Scherzer, Stocker, Sturgess, Tajima, Urquilla, Webb, Winquist   +44 more
core   +3 more sources