Results 11 to 20 of about 38,478 (200)
Ouabain suppresses the migratory behavior of lung cancer cells. [PDF]
PLoS ONE, 2013 The migratory capability of cancer cells is one of the most important hallmarks reflecting metastatic potential. Ouabain, an endogenous cardiac glycoside produced by the adrenal gland, has been previously reported to have anti-tumor activities; however ...
Varisa Pongrakhananon +2 more
doaj +2 more sources
Ouabain Modulates the Distribution of Connexin 43 in Epithelial Cells [PDF]
Cellular Physiology and Biochemistry, 2016 Background/Aims: The fact that ouabain has been identified as an endogenous substance, led us to inquire its physiological role in epithelial cells. Based on previous observations, we hypothesized that it influences processes related to cell contacts ...
Arturo Ponce +6 more
doaj +2 more sources
Ouabain Counteracts Retinal Ganglion Cell Death Through Modulation of BDNF and IL-1 Signaling Pathways [PDF]
Brain SciencesBackground: Ouabain is a steroid hormone that binds to the sodium pump (Na+, K+-ATPase) at physiological (nanomolar) concentrations, activating different signaling pathways.
Amanda Candida da Rocha Oliveira +8 more
doaj +2 more sources
Ouabain at nanomolar concentrations is cytotoxic for biliary tract cancer cells.
PLoS ONE, 2023 Biliary tract cancer is a deadly disease with limited therapeutic options. Ouabain is a well-known inhibitor of the pumping function of Na+/K+-ATPase, though there is evidence that low concentrations of ouabain lead to a reduction of cell viability of ...
Christian Mayr +12 more
doaj +2 more sources
Aging Cell, 2021 The expression of BRAF‐V600E triggers oncogene‐induced senescence in normal cells and is implicated in the development of several cancers including melanoma.
Valentin L'Hôte +7 more
semanticscholar +1 more source
Leukemic Cells Hijack Stromal Bioelectricity to Reprogram the Bone Marrow Niche via CaV1.2-Dependent Mechanisms. [PDF]
Adv Sci (Weinh)Leukemic blasts induce membrane depolarization in mesenchymal stromal cells (MSCs), contributing to a dysfunctional niche that favors leukemia progression. Here, it is demonstrated that restoring the expression of CaV1.2 calcium channel in AML‐MSCs repolarizes their membrane potential, reprogramming them toward a healthy phenotype.
Da Ros A +11 more
europepmc +2 more sources
Current Issues in Molecular Biology, 2023 Ouabain, an organic compound with the ability to strengthen the contraction of the heart muscle, was originally derived from plants. It has been observed that certain mammalian species, including humans, naturally produce ouabain, leading to its ...
Jacqueline Martínez-Rendón +6 more
doaj +1 more source
Acta Pharmacologica Sinica, 2019 In addition to the well-known cardiotonic effects, cardiac glycosides (CGs) produce potent anticancer effects with various molecular mechanisms. We previously show that ouabain induces autophagic cell death in human lung cancer cells by regulating AMPK ...
Jiajia Shen +3 more
semanticscholar +1 more source
Effect of ouabain on calcium signaling in rodent brain: A systematic review of in vitro studies
Frontiers in Pharmacology, 2022 The Na+/K+-ATPase is an integral membrane ion pump, essential to maintaining osmotic balance in cells in the presence of cardiotonic steroids; more specifically, ouabain can be an endogenous modulator of the Na+/K+-ATPase. Here, we conducted a systematic
Jacqueline Alves Leite +8 more
doaj +1 more source
Brazilian Journal of Medical and Biological Research, 2001 Ouabain increases vascular resistance and may induce hypertension by inhibiting the Na+ pump. The effects of 0.18 and 18 µg/kg, and 1.8 mg/kg ouabain pretreatment on the phenylephrine (PHE; 0.1, 0.25 and 0.5 µg, in bolus)-evoked pressor responses were ...
L.V. Rossoni, V.D. Pinto, D.V. Vassallo
doaj +1 more source