Results 11 to 20 of about 18,820 (207)
Current Issues in Molecular Biology, 2023 Ouabain, an organic compound with the ability to strengthen the contraction of the heart muscle, was originally derived from plants. It has been observed that certain mammalian species, including humans, naturally produce ouabain, leading to its ...
Jacqueline Martínez-Rendón +6 more
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Ouabain and Serum Sodium [PDF]
Hypertension, 2005 To the Editor: Sodium-dependent mechanisms play a role in the pathogenesis of hypertension. He et al recently demonstrated that in normotensive and hypertensive subjects an acute reduction in salt intake, from 350 to 10 mmol/d for 5 days, was associated with a decline in serum sodium by ≈3 mmol/L.1 Conversely, a progressive increase in salt intake ...
Gąsowski, Jerzy +3 more
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Neuroinflammation and Neutrophils: Modulation by Ouabain [PDF]
Frontiers in Pharmacology, 2022 Cardiotonic steroids are natural compounds that present many physiological and pharmacological functions. They bind Na+/K+-ATPase (NKA) modifying cellular ion concentration and trigger cell signaling mechanisms without altering ion balance. These steroids are known to modulate some immune responses, including cytokine production, neutrophil migration ...
Jacqueline Alves Leite +5 more
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Cardiac Glycoside Ouabain Exerts Anticancer Activity via Downregulation of STAT3
Frontiers in Oncology, 2021 Cardiac glycosides are plant-derived steroid-like compounds which have been used for the treatment of cardiovascular diseases. Ouabain, a cardiotonic steroid and specific Na+/K+-ATPase inhibitor, has been rediscovered for its potential use in the ...
Jie Du +5 more
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On the structure of endogenous ouabain [PDF]
Proceedings of the National Academy of Sciences, 1999 The ouabain-like sodium pump inhibitor in mammals (so-called “endogenous ouabain”) has been considered a subtle structural isomer of ouabain. Its structural investigation, however, has long been hindered by the paucity of sample material. Our recent purification of endogenous ouabain (3 μg) from bovine hypothalamus allowed the measurement of its1H-NMR.
Charles E. Bell +9 more
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Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain
Frontiers in Physiology, 2017 Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described.
Luiz H. A. Cavalcante-Silva +9 more
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Radioiodinated Tyrosyl-Ouabain and Measurement of a Circulating Ouabain-like Compound [PDF]
Clinical Chemistry, 2001 Abstract Background: Assays for endogenous ouabain, a cardiac glycoside believed to be involved in blood pressure and volume regulation, are characterized by laboratory-specific plasma values that are measured by different assays. Because of this variability, our study focused on the development of a new 125I-labeled ouabain derivative ...
Sighvatur S. Árnason +5 more
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Hypertensive effects of the iv administration of picomoles of ouabain
Brazilian Journal of Medical and Biological Research, 2011 Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plasma of several mammals and is associated with the development of hypertension. In addition, plasma ouabain is increased in several hypertension models, and
A.S. Padilha +4 more
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Wistar rats resistant to the hypertensive effects of ouabain exhibit enhanced cardiac vagal activity and elevated plasma levels of calcitonin gene-related peptide. [PDF]
PLoS ONE, 2014 Ouabain is a cardiac glycoside produced in the adrenal glands and hypothalamus. It affects the function of all cells by binding to Na+/K+-ATPase. Several lines of evidence suggest that endogenous ouabain could be involved in the pathogenesis of essential
Elham Ghadhanfar +2 more
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Consequences of the Lack of TNFR1 in Ouabain Response in the Hippocampus of C57BL/6J Mice
Biomedicines, 2022 Ouabain is a cardiac glycoside that has a protective effect against neuroinflammation at low doses through Na+/K+-ATPase signaling and that can activate tumor necrosis factor (TNF) in the brain.
Paula Fernanda Kinoshita +7 more
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