Results 21 to 30 of about 18,941 (209)
Ouabain Increases Gap Junctional Communication in Epithelial Cells
Cellular Physiology and Biochemistry, 2014 Background/Aims: The finding that endogenous ouabain acts as a hormone prompted efforts to elucidate its physiological function. In previous studies, we have shown that 10 nM ouabain (i.e., a concentration within the physiological range) modulates cell ...
Arturo Ponce +8 more
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Effect of ouabain on calcium signaling in rodent brain: A systematic review of in vitro studies
Frontiers in Pharmacology, 2022 The Na+/K+-ATPase is an integral membrane ion pump, essential to maintaining osmotic balance in cells in the presence of cardiotonic steroids; more specifically, ouabain can be an endogenous modulator of the Na+/K+-ATPase. Here, we conducted a systematic
Jacqueline Alves Leite +8 more
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Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents. [PDF]
PLoS ONE, 2013 Modulation of the DNA repair pathway is an emerging target for the development of anticancer drugs. DNA interstrand cross-links (ICLs), one of the most severe forms of DNA damage caused by anticancer drugs such as cisplatin and mitomycin C (MMC ...
Dong Wha Jun +5 more
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The Influence of Ouabain on Human Dendritic Cells Maturation
Mediators of Inflammation, 2014 Although known as a Na,K-ATPase inhibitor, several other cellular and systemic actions have been ascribed to the steroid Ouabain (Oua). Particularly in the immune system, our group showed that Ouabain acts on decreasing lymphocyte proliferation ...
C. R. Nascimento +6 more
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Journal of Pharmacological Sciences, 2007 Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis was examined with a specific inhibitor, SEA0400. In right ventricular papillary muscle isolated from guinea-pig ventricle, 1 µM SEA0400, which specifically inhibits ...
Hikaru Tanaka +5 more
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Ouabain enhances ADPKD cell apoptosis via the intrinsic pathway
Frontiers in Physiology, 2016 Progression of autosomal dominant polycystic kidney disease (ADPKD) is highly influenced by factors circulating in blood. We have shown that the hormone ouabain enhances several characteristics of the ADPKD cystic phenotype, including the rate of cell ...
Gustavo eBlanco, Jessica eVenugopal
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Discover Oncology, 2023 Background Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with poor prognosis. GMB are highly recurrent mainly because of radio- and chemoresistance.
Heidrun Weidemann +4 more
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Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice
Mediators of Inflammation, 2011 Ouabain, an inhibitor of the Na+/K+-ATPase pump, was identified as an endogenous substance of human plasma. Ouabain has been studied for its ability to interfere with various regulatory mechanisms. Despite the studies portraying the ability of ouabain to
Danielle Ingrid Bezerra de Vasconcelos +7 more
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Frontiers in Physiology, 2020 The cardiotonic steroids (CTS), such as ouabain and marinobufagenin, are thought to be adrenocortical hormones secreted during exercise and the stress response. The catalytic α-subunit of Na,K-ATPase (NKA) is a CTS receptor, whose largest pool is located
Sergej Pirkmajer +13 more
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THE EFFECT OF LITHIUM ON THE INOTROPIC EFFECT OF OUABAIN AND MANIFESTATION OF ARRHYTHMIA IN GUINEA-PIG ATRIA [PDF]
Acta Medica Iranica, 1995 rli....xposure ofthe guinea-pig whole a/ria to lithium (1 and 5 mM) produced a reduction ofinotropic response to ouubain. The inhibitory effect oflithium (1 m"f) was slight, whereas lithium (5 mM) significantly reduced tlze response oj the preparations ...
Ahmad Reza Dehpour +3 more
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