Results 21 to 30 of about 37,475 (253)

Thyroid thermogenesis in adult rat hepatocytes in primary monolayer culture: direct action of thyroid hormone in vitro. [PDF]

, 1979
We have studied the effect of 3,5,3'-triiodothyronine (T3) on the respiration of adult rat hepatocytes in primary monolayer culture prepared from hypothyroid rat liver. After addition of T3 to the culture medium at a concentration of 2 x 10(-7) M, oxygen
Bissell, DM, Edelman, IS, Ismail-Beigi, F   +2 more
core   +2 more sources

Hypertensive effects of the iv administration of picomoles of ouabain

Brazilian Journal of Medical and Biological Research, 2011
Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plasma of several mammals and is associated with the development of hypertension. In addition, plasma ouabain is increased in several hypertension models, and
A.S. Padilha, M. Salaices, D.V. Vassallo, P.R. Batista, F.D.M. Siman   +4 more
doaj   +3 more sources

Ouabain Increases Gap Junctional Communication in Epithelial Cells

Cellular Physiology and Biochemistry, 2014
Background/Aims: The finding that endogenous ouabain acts as a hormone prompted efforts to elucidate its physiological function. In previous studies, we have shown that 10 nM ouabain (i.e., a concentration within the physiological range) modulates cell ...
Arturo Ponce, Isabel Larre, Aida Castillo, Refugio García-Villegas, Adrián Romero, Catalina Flores-Maldonado, Jacqueline Martinez-Rendón, Rubén Gerardo Contreras, Marcelino Cereijido   +8 more
doaj   +1 more source

NaCl transport stimulates prostaglandin release in cultured renal epithelial (MDCK) cells [PDF]

, 1986
Prostaglandins (PGs) can modulate a variety of renal functions, including Na+ and Cl- reabsorption. However, it is not known if a direct interdependence exists between PG synthesis and transport activity. The present study was done to find out whether or
Bauer, C., Brown, C. D., Kurtz, Armin, Pfeilschifter, J.   +3 more
core   +1 more source

Ouabain and Serum Sodium [PDF]

Hypertension, 2005
To the Editor: Sodium-dependent mechanisms play a role in the pathogenesis of hypertension. He et al recently demonstrated that in normotensive and hypertensive subjects an acute reduction in salt intake, from 350 to 10 mmol/d for 5 days, was associated with a decline in serum sodium by ≈3 mmol/L.1 Conversely, a progressive increase in salt intake ...
Gasowski, Jerzy, Manunta, Paolo, Bianchi, Giuseppe, Staessen, Jan A.   +3 more
openaire   +2 more sources

Involvement of the Na+/Ca2+ Exchanger in Ouabain-Induced Inotropy and Arrhythmogenesis in Guinea-Pig Myocardium as Revealed by SEA0400

Journal of Pharmacological Sciences, 2007
Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis was examined with a specific inhibitor, SEA0400. In right ventricular papillary muscle isolated from guinea-pig ventricle, 1 µM SEA0400, which specifically inhibits ...
Hikaru Tanaka, Hideaki Shimada, Iyuki Namekata, Toru Kawanishi, Naoko Iida-Tanaka, Koki Shigenobu   +5 more
doaj   +1 more source

Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents. [PDF]

PLoS ONE, 2013
Modulation of the DNA repair pathway is an emerging target for the development of anticancer drugs. DNA interstrand cross-links (ICLs), one of the most severe forms of DNA damage caused by anticancer drugs such as cisplatin and mitomycin C (MMC ...
Dong Wha Jun, Mihwa Hwang, Hyun Jung Kim, Soo Kyung Hwang, Sunshin Kim, Chang-Hun Lee   +5 more
doaj   +1 more source

Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice

Mediators of Inflammation, 2011
Ouabain, an inhibitor of the Na+/K+-ATPase pump, was identified as an endogenous substance of human plasma. Ouabain has been studied for its ability to interfere with various regulatory mechanisms. Despite the studies portraying the ability of ouabain to
Danielle Ingrid Bezerra de Vasconcelos, Jacqueline Alves Leite, Luciana Teles Carneiro, Márcia Regina Piuvezam, Maria Raquel Vitorino de Lima, Liana Clébia Lima de Morais, Vivian Mary Rumjanek, Sandra Rodrigues-Mascarenhas   +7 more
doaj   +1 more source

Ion activities and potassium uptake mechanisms of glial cells in guinea-pig olfactory cortex slices. [PDF]

, 1987
1. Double-barrelled ion-sensitive micro-electrodes were used to measure changes in the intracellular activities of K+, Na+ and Cl- (aiK, aiNa, aiCl) in glial cells of slices from guinea-pig olfactory cortex during repetitive stimulation of the lateral ...
Ballanyi, Klaus, Grafe, Peter, Ten Bruggencate, Gerrit   +2 more
core   +2 more sources

Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice [PDF]

, 2005
BACKGROUND: The pathology of Alzheimer's disease (AD) is comprised of extracellular amyloid plaques, intracellular tau tangles, dystrophic neurites and neurodegeneration. The mechanisms by which these various pathological features arise are under intense
Dickey, Chad A, Freeman, Melissa J, Gordon, Marcia N, Herber, Donna L, Morgan, Dave, Wilcock, Donna M   +5 more
core   +3 more sources