Results 21 to 30 of about 29,179 (204)
The Influence of Ouabain on Human Dendritic Cells Maturation
Mediators of Inflammation, 2014 Although known as a Na,K-ATPase inhibitor, several other cellular and systemic actions have been ascribed to the steroid Ouabain (Oua). Particularly in the immune system, our group showed that Ouabain acts on decreasing lymphocyte proliferation ...
C. R. Nascimento +6 more
doaj +1 more source
Ouabain and Serum Sodium [PDF]
Hypertension, 2005 To the Editor: Sodium-dependent mechanisms play a role in the pathogenesis of hypertension. He et al recently demonstrated that in normotensive and hypertensive subjects an acute reduction in salt intake, from 350 to 10 mmol/d for 5 days, was associated with a decline in serum sodium by ≈3 mmol/L.1 Conversely, a progressive increase in salt intake ...
Gasowski, Jerzy +3 more
openaire +2 more sources
Role of carbon dioxide and ion transport in the formation of sub-embryonic fluid by the blastoderm of the Japanese quail [PDF]
, 2002 1. The explanted blastoderm of the Japanese quail was used to explore the role of ions and carbon dioxide in determining the rate of sub-embryonic fluid (SEF) production between 54 and 72 h of incubation. 2.
AR A. +27 more
core +1 more source
Journal of Pharmacological Sciences, 2007 Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis was examined with a specific inhibitor, SEA0400. In right ventricular papillary muscle isolated from guinea-pig ventricle, 1 µM SEA0400, which specifically inhibits ...
Hikaru Tanaka +5 more
doaj +1 more source
Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents. [PDF]
PLoS ONE, 2013 Modulation of the DNA repair pathway is an emerging target for the development of anticancer drugs. DNA interstrand cross-links (ICLs), one of the most severe forms of DNA damage caused by anticancer drugs such as cisplatin and mitomycin C (MMC ...
Dong Wha Jun +5 more
doaj +1 more source
Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice
Mediators of Inflammation, 2011 Ouabain, an inhibitor of the Na+/K+-ATPase pump, was identified as an endogenous substance of human plasma. Ouabain has been studied for its ability to interfere with various regulatory mechanisms. Despite the studies portraying the ability of ouabain to
Danielle Ingrid Bezerra de Vasconcelos +7 more
doaj +1 more source
Consequences of the Lack of TNFR1 in Ouabain Response in the Hippocampus of C57BL/6J Mice
Biomedicines, 2022 Ouabain is a cardiac glycoside that has a protective effect against neuroinflammation at low doses through Na+/K+-ATPase signaling and that can activate tumor necrosis factor (TNF) in the brain.
Paula Fernanda Kinoshita +7 more
doaj +1 more source
Intracellular free sodium and potassium, post-carbachol hyperpolarization, and extracellular potassium-undershoot in rat sympathetic neurones [PDF]
, 1983 Double-barrelled ion-sensitive microelectrodes were used to record the free intracellular Na+- and K+-concentrations ([Na+]i, [K+]i) and to determine their relation to changes in membrane potential and extracellular K+ ([K+]e) in rat sympathetic ganglia.
Brown +15 more
core +1 more source
NaCl transport stimulates prostaglandin release in cultured renal epithelial (MDCK) cells [PDF]
, 1986 Prostaglandins (PGs) can modulate a variety of renal functions, including Na+ and Cl- reabsorption. However, it is not known if a direct interdependence exists between PG synthesis and transport activity. The present study was done to find out whether or
Bauer, C. +3 more
core +1 more source
Discover Oncology, 2023 Background Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with poor prognosis. GMB are highly recurrent mainly because of radio- and chemoresistance.
Heidrun Weidemann +4 more
doaj +1 more source