Results 31 to 40 of about 18,941 (209)
Ouabain affects cell migration via Na,K-ATPase-p130cas and via nucleus-centrosome association. [PDF]
PLoS ONE, 2017 Na,K-ATPase is a membrane protein that catalyzes ATP to maintain transmembrane sodium and potassium gradients. In addition, Na,K-ATPase also acts as a signal-transducing receptor for cardiotonic steroids such as ouabain and activates a number of ...
Young Ou +3 more
doaj +1 more source
Effects of Ouabain, Atropine, and Ouabain and Atropine, on A-V Nodal Conduction in Man [PDF]
Circulation Research, 1967 The prolongation of A-V transmission time that occurs with increasing rates of right atrial pacing has been used to study the effect of ouabain and of ouabain plus atropine on A-V nodal conduction in 14 patients with normal A-V nodes. Drugs were injected into the superior vena cava or pulmonary artery over a 1- to 2-min period.
Richard A. Carleton +2 more
openaire +3 more sources
Antiviral activity of ouabain against a Brazilian Zika virus strain
Scientific Reports, 2022 Zika virus (ZIKV) is an emerging arbovirus associated with neurological disorders. Currently, no specific vaccines or antivirals are available to treat the ZIKV infection.
Deyse Cristina Madruga Carvalho +9 more
doaj +1 more source
Ouabain suppresses the migratory behavior of lung cancer cells. [PDF]
PLoS ONE, 2013 The migratory capability of cancer cells is one of the most important hallmarks reflecting metastatic potential. Ouabain, an endogenous cardiac glycoside produced by the adrenal gland, has been previously reported to have anti-tumor activities; however ...
Varisa Pongrakhananon +2 more
doaj +1 more source
The role of Na+/K+-ATPase during chick skeletal myogenesis. [PDF]
PLoS ONE, 2015 The formation of a vertebrate skeletal muscle fiber involves a series of sequential and interdependent events that occurs during embryogenesis. One of these events is myoblast fusion which has been widely studied, yet not completely understood.
Taissa Neustadt Oliveira +6 more
doaj +1 more source
Ouabain - the insulin of the heart
International Journal of Clinical Practice, 2010 Prior to the introduction of modern drugs like angiotensin converting enzyme inhibitors and β-adrenergic receptor antagonists, the cardiac glycoside ouabain (referred to as g-Strophanthin in German) has routinely been used in treatment of heart diseases.
openaire +3 more sources
The Chemistry and Biology of the Tetrodotoxin Natural Product Family
Angewandte Chemie International Edition, EarlyView.Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl +6 more
wiley +1 more source
Ouabain Modulates Zymosan-Induced Peritonitis in Mice
Mediators of Inflammation, 2015 Ouabain, a potent inhibitor of the Na+, K+-ATPase, was identified as an endogenous substance. Recently, ouabain was shown to affect various immunological processes.
Jacqueline Alves Leite +8 more
doaj +1 more source
BMEMat, EarlyView.This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan +12 more
wiley +1 more source
Developmental Dynamics, EarlyView.Abstract Background Previous experiments inducing leakage of embryonic cerebrospinal fluid (CSF) suggest the necessity of intraventricular CSF pressure (PCSF) for brain morphogenesis. Nevertheless, how embryonic PCSF occurs is unclear, especially in utero. Results Using a Landis water manometer, we measured PCSF in fetal mice isolated from the amniotic
Koichiro Tsujikawa +2 more
wiley +1 more source