Results 31 to 40 of about 29,179 (204)
Hypertension, 2016 In this brief article, we summarize recent reports about endogenous ouabain (EO), a cardiotonic steroid hormone. This includes analysis of mammalian EO, the discovery of EO isomers, regulation of intracellular signaling by EO, and the roles of EO in hypertension, pregnancy, and heart and kidney diseases.
John M, Hamlyn, Mordecai P, Blaustein
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Sodium chloride transport of normal and dietary enlarged rat cecum in vitro [PDF]
, 1998 Sodium chloride transport across isolated cecum mucosa was investigated in normal rats and rats with adaptive cecum growth induced by dietary polyethylene glycol (PEG). The normal cecum absorbed CI in excess of Na with a small short-circuit current (Isc).
Loeschke, Klaus +2 more
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Ouabain enhances ADPKD cell apoptosis via the intrinsic pathway
Frontiers in Physiology, 2016 Progression of autosomal dominant polycystic kidney disease (ADPKD) is highly influenced by factors circulating in blood. We have shown that the hormone ouabain enhances several characteristics of the ADPKD cystic phenotype, including the rate of cell ...
Gustavo eBlanco, Jessica eVenugopal
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THE EFFECT OF LITHIUM ON THE INOTROPIC EFFECT OF OUABAIN AND MANIFESTATION OF ARRHYTHMIA IN GUINEA-PIG ATRIA [PDF]
Acta Medica Iranica, 1995 rli....xposure ofthe guinea-pig whole a/ria to lithium (1 and 5 mM) produced a reduction ofinotropic response to ouubain. The inhibitory effect oflithium (1 m"f) was slight, whereas lithium (5 mM) significantly reduced tlze response oj the preparations ...
Ahmad Reza Dehpour +3 more
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Radioiodinated Tyrosyl-Ouabain and Measurement of a Circulating Ouabain-like Compound [PDF]
Clinical Chemistry, 2001 Abstract Background: Assays for endogenous ouabain, a cardiac glycoside believed to be involved in blood pressure and volume regulation, are characterized by laboratory-specific plasma values that are measured by different assays. Because of this variability, our study focused on the development of a new 125I-labeled ouabain derivative ...
O, Vakkuri +5 more
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Different types of potassium transport linked to carbachol and γ-aminobutyric acid actions in rat sympathetic neurons [PDF]
, 1984 Carbachol and γ-aminobutyric acid depolarize mammalian sympathetic neurons and increase the free extracellular K+-concentration. We have used double-barrelled ion-sensitive microelectrodes to determine changes of the membrane potential and of the free ...
Ballanyi, Klaus +3 more
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Frontiers in Physiology, 2020 The cardiotonic steroids (CTS), such as ouabain and marinobufagenin, are thought to be adrenocortical hormones secreted during exercise and the stress response. The catalytic α-subunit of Na,K-ATPase (NKA) is a CTS receptor, whose largest pool is located
Sergej Pirkmajer +13 more
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Ouabain affects cell migration via Na,K-ATPase-p130cas and via nucleus-centrosome association. [PDF]
PLoS ONE, 2017 Na,K-ATPase is a membrane protein that catalyzes ATP to maintain transmembrane sodium and potassium gradients. In addition, Na,K-ATPase also acts as a signal-transducing receptor for cardiotonic steroids such as ouabain and activates a number of ...
Young Ou +3 more
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Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia [PDF]
, 2013 <p>Background Comparative analysis of tissue-specific transcriptomes is a powerful technique to uncover tissue functions. Our FlyAtlas.org provides authoritative gene expression levels for multiple tissues of Drosophila melanogaster (1).
Chintapalli, V.R. +4 more
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The envenomation of general physiology throughout the last century. [PDF]
, 2017 Toxins are the poisonous products of organisms. Toxins serve vital defensive and offensive functions for those that harbor them: stinging scorpions, pesticidal plants, sanguinary snakes, fearless frogs, sliming snails, noxious newts, and smarting spiders.
Sack, Jon T
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