Results 31 to 40 of about 38,478 (200)

Markedly divergent effects of Ouabain on a Temozolomide-resistant (T98G) vs. a Temozolomide-sensitive (LN229) Glioblastoma cell line

Discover Oncology, 2023
Background Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with poor prognosis. GMB are highly recurrent mainly because of radio- and chemoresistance.
Heidrun Weidemann, Daniel Feger, Jan E. Ehlert, Marcus M. Menger, Robert C. Krempien   +4 more
doaj   +1 more source

THE EFFECT OF LITHIUM ON THE INOTROPIC EFFECT OF OUABAIN AND MANIFESTATION OF ARRHYTHMIA IN GUINEA-PIG ATRIA [PDF]

Acta Medica Iranica, 1995
rli....xposure ofthe guinea-pig whole a/ria to lithium (1 and 5 mM) produced a reduction ofinotropic response to ouubain. The inhibitory effect oflithium (1 m"f) was slight, whereas lithium (5 mM) significantly reduced tlze response oj the preparations ...
Ahmad Reza Dehpour, Kambiz Harirchi, Farokh Shadan, Aziz Delfan   +3 more
doaj   +2 more sources

Ouabain affects cell migration via Na,K-ATPase-p130cas and via nucleus-centrosome association. [PDF]

PLoS ONE, 2017
Na,K-ATPase is a membrane protein that catalyzes ATP to maintain transmembrane sodium and potassium gradients. In addition, Na,K-ATPase also acts as a signal-transducing receptor for cardiotonic steroids such as ouabain and activates a number of ...
Young Ou, Chen Xuan Pan, Jeremy Zuo, Frans A van der Hoorn   +3 more
doaj   +1 more source

Antiviral activity of ouabain against a Brazilian Zika virus strain

Scientific Reports, 2022
Zika virus (ZIKV) is an emerging arbovirus associated with neurological disorders. Currently, no specific vaccines or antivirals are available to treat the ZIKV infection.
Deyse Cristina Madruga Carvalho, Poliana Gomes da Silva, Willyenne Marília Dantas, Severino Jefferson Ribeiro da Silva, Caroline Targino Alves da Silva, Elton José Ferreira Chaves, Demetrius Antônio Machado de Araújo, Ronaldo Nascimento de Oliveira, Sandra Rodrigues-Mascarenhas, Lindomar José Pena   +9 more
doaj   +1 more source

Effects of Renal Denervation on Ouabain-Induced Hypertension in Rats

International Journal of Hypertension
Background. Ouabain, a Na+, K+-ATPase inhibitor, is elevated in hypertensive patients. Evidence suggests ouabain contributes to hypertension mainly through activation of the sympathetic nervous system (SNS).
Minna Tang, Jialu Hu, Wenshu Li, Ningzhi Zhang, Sisi Ning, Yan Yan, Zhaoqiang Cui   +6 more
doaj   +1 more source

Ouabain prevents pathological cardiac hypertrophy and heart failure through activation of phosphoinositide 3-kinase α in mouse

Cell & Bioscience, 2015
Use of low doses of digitalis to prevent the development of heart failure was advocated decades ago, but conflicting results of early animal studies dissuaded further research on this issue. Recent discoveries of digitalis effects on cell signal pathways
Jian Wu, Daxiang Li, Lingling Du, Mustafa Baldawi, Marjorie E. Gable, A. Askari, Lijun Liu   +6 more
semanticscholar   +1 more source

Repurposing Cardiac Glycosides to Potentiate CD47 Blockade through Calreticulin‐mediated Phagocytic Effects for Lung Cancer Treatment

Advanced Science, EarlyView.
Repurposing cardiac glycosides (CGs) significantly strengthens the efficacy of anti‐CD47 antibody for lung cancer treatment by boosting macrophage phagocytosis. This novel combination blocks the “don't eat me” signal and increases dual “eat‐me” signals, Fc‐FcγR and cell surface expression of calreticulin (ecto‐CRT).
Zi‐Han Ye, Wei‐Bang Yu, Mu‐Yang Huang, Yan‐Yan Chen, Le‐Le Zhang, Chung‐Hang Leung, Xiao‐Lei Zhang, Zhenghai Tang, Ting Li, Jin‐Jian Lu   +9 more
wiley   +1 more source

The role of Na+/K+-ATPase during chick skeletal myogenesis. [PDF]

PLoS ONE, 2015
The formation of a vertebrate skeletal muscle fiber involves a series of sequential and interdependent events that occurs during embryogenesis. One of these events is myoblast fusion which has been widely studied, yet not completely understood.
Taissa Neustadt Oliveira, Ana Claudia Possidonio, Carolina Pontes Soares, Rodrigo Ayres, Manoel Luis Costa, Luis Eduardo Menezes Quintas, Cláudia Mermelstein   +6 more
doaj   +1 more source

Inactivation of Src-to-Ezrin Pathway: A Possible Mechanism in the Ouabain-Mediated Inhibition of A549 Cell Migration

BioMed Research International, 2015
Ouabain, a cardiac glycoside found in plants, is primarily used in the treatment of congestive heart failure and arrhythmia because of its ability to inhibit Na+/K+-ATPase pump.
Hye Kyoung Shin, Byung Jun Ryu, Sik-Won Choi, S. Kim, Kyunglim Lee   +4 more
semanticscholar   +1 more source

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Advanced Science, EarlyView.
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
wiley   +1 more source