Results 51 to 60 of about 38,478 (200)

Effects of ouabain on vascular reactivity

Brazilian Journal of Medical and Biological Research, 1997
Ouabain is an endogenous substance occurring in the plasma in the nanomolar range, that has been proposed to increase vascular resistance and induce hypertension. This substance acts on the a-subunit of Na+,K+-ATPase inhibiting the Na+-pump activity.
Vassallo D.V., E. Songu-Mize, L.V. Rossoni, S.M.C. Amaral   +3 more
doaj   +1 more source

Ouabain Affects the Expression of Activation Markers, Cytokine Production, and Endocytosis of Human Monocytes

Mediators of Inflammation, 2014
Ouabain is a steroid capable of binding to and inhibiting Na+,-K+-ATPase. Studies have demonstrated some actions of ouabain on immune cells, which indicated both pro- and anti-inflammatory properties of this molecule.
Mariana Pires Teixeira, V. Rumjanek
semanticscholar   +1 more source

Expression of corticoid‐regulatory genes in the gills of Atlantic salmon (Salmo salar) parr and smolt and during salinity acclimation

Journal of Fish Biology, EarlyView.
Abstract In teleost fishes, cortisol is the major corticoid and has both glucocorticoid and mineralocorticoid actions. However, how fish tissues discriminate between these distinct corticosteroid actions is unclear. In mammals, the major factors responsible for intracellular corticosteroid regulation are glucocorticoid receptors (grs) and the ...
Makoto Kusakabe, Takashi Yada, Graham Young, Amy M. Regish, Stephen D. McCormick   +4 more
wiley   +1 more source

Impact of Wild Edible Fruits of Arbutus unedo and Crataegus monogyna on Gut Motility, Contraction, Secretion, and Glucose Regulation

Neurogastroenterology &Motility, EarlyView.
Impact of Wild Edible Fruits of Arbutus unedo and Crataegus monogyna on Gut Motility, Contraction, Secretion, and Glucose Regulation. ABSTRACT Background Arbutus and hawthorn fruits are commonly utilized in traditional medicine to address various gastrointestinal (GI) ailments.
Soumaya Wahabi, Kais Rtibi, Chaima Abidi, Mourad Jridi, Bernard Gressier, Hichem Sebai, Bruno Eto   +6 more
wiley   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, EarlyView.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

Cell Signaling Associated with Na+/K+-ATPase: Activation of Phosphatidylinositide 3-Kinase IA/Akt by Ouabain Is Independent of Src

Biochemistry, 2013
Exposure of intact cells to selective inhibitors of Na+/K+-ATPase such as ouabain activates several growth-related cell signaling pathways. It has been suggested that the initial event of these pathways is the binding of ouabain to a preexisting complex ...
Jian Wu, E. Akkuratov, Y. Bai, Cassie Miller Gaskill, A. Askari, Lijun Liu   +5 more
semanticscholar   +1 more source

Intrinsic mechanisms contributing to the biophysical signature of mouse gamma motoneurons

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we identify key intrinsic properties underlying the distinct biophysical signature of gamma motoneurons (blue): a motoneuron subtype that innervates intrafusal muscle fibres (orange) to adjust spindle afferent (black) sensitivity for detecting muscle length changes during movement.
Simon A. Sharples, Struan J. Nisbet, Matthew J. Broadhead, Dennis Bo Jensen, Francesca L. Sorrell, Claire F. Meehan, Gareth B. Miles   +6 more
wiley   +1 more source

Ouabain inhibits monocyte activation in vitro: prevention of the proinflammatory mCD14+/CD16+ subset appearance and cell-size progression

Journal of Experimental Pharmacology, 2012
Raphael C Valente,1 Elizabeth G Araujo,2 Vivian M Rumjanek11Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; 2Departamento de Neurobiologia, Universidade Federal Fluminense, Rio de ...
Valente RC, Araujo EG, Rumjanek VM
doaj  

Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
ABSTRACT Cyanide is widely recognized for its potent toxicity, yet evidence shows that concentrations below 1 μM may enhance cytochrome c oxidase activity and have a regulatory function. Recent findings also demonstrate that mammalian cells, including endothelial cells, produce cyanide endogenously, where it can modulate mitochondrial bioenergetics ...
Elif Alan‐Albayrak, Ulf Simonsen
wiley   +1 more source

Ouabain-Induced Cell Death and Survival. Role of α1-Na,K-ATPase-Mediated Signaling and [Na+]i/[K+]i-Dependent Gene Expression

Frontiers in Physiology, 2020
Ouabain is of cardiotonic steroids (CTS) family that is plant-derived compounds and is known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na,K-ATPase, the enzyme, which pumps Na+ and K+ across plasma membrane of ...
Olga Dmitrievna Lopina, Artem Mikhaylovich Tverskoi, Artem Mikhaylovich Tverskoi, Elizaveta Andreevna Klimanova, Svetlana Vadimovna Sidorenko, Sergei Nikolaevich Orlov   +5 more
doaj   +1 more source