Results 61 to 70 of about 18,941 (209)

Ouabain Modulates the Distribution of Connexin 43 in Epithelial Cells

Cellular Physiology and Biochemistry, 2016
Background/Aims: The fact that ouabain has been identified as an endogenous substance, led us to inquire its physiological role in epithelial cells. Based on previous observations, we hypothesized that it influences processes related to cell contacts ...
Arturo Ponce, Isabel Larre, Aida Castillo, Catalina Flores-Maldonado, Odette Verdejo-Torres, Ruben Gerardo Contreras, Marcelino Cereijido   +6 more
doaj   +1 more source

Persistent Renal Oxidative Stress Despite Mannitol Nephroprotection: The Impact of Social‐Single Prolonged Stress in Male and Female Rats Exposed to Cisplatin

Cell Biochemistry and Function, Volume 43, Issue 7, July 2025.
ABSTRACT Cisplatin (CIS) is a chemotherapeutic agent known for nephrotoxicity through oxidative stress. Cancer treatment is also associated with psychological stress. Repeated exposure to social‐single prolonged stress (social‐SPS) modulates long‐term renal oxidative damage and apoptosis in a sex‐dependent manner in rats treated with cisplatin (CIS ...
Juliano Ten Kathen Jung, Isabella Pregardier Klann, Bruna Cruz Weber Fulco, Vanessa Angonesi Zborowski, Gilson Zeni, Cristina Wayne Nogueira   +5 more
wiley   +1 more source

High sensitivity to ocean acidification in wild out‐migrating juvenile Pacific salmon is not impacted by feeding success

Ecological Applications, Volume 35, Issue 5, July 2025.
Abstract Salmon populations are declining worldwide, with high mortality rates during juvenile marine migration presenting a bottleneck to recruitment. The ocean conditions along the main migratory route of juvenile salmon in British Columbia are characterized by high variability in CO2, with the amplitude, duration, and frequency of ocean ...
Andrea Y. Frommel, Arash Akbarzadeh, Virginie Chalifoux, Tobi J. Ming, Brenna Collicutt, Kate Rolheiser, Rumer Opie, Kristina M. Miller, Colin J. Brauner, Brian P. V. Hunt   +9 more
wiley   +1 more source

Na+,K+-ATPase is the membrane receptor of hormone ouabain

Communicative & Integrative Biology, 2010
At 10 nM, ouabain elicits changes in cell contacts, which are independent and usually in opposite direction to effects occurring at μM levels, suggesting that these depend on entirely different mechanisms.1 However, this does not discard the possibility ...
Isabel Larre, Marcelino Cereijido
doaj   +1 more source

Comparative analysis of the mechanokinetics of contractile activity of myometrium smooth muscles under calixarene C-99 and ouabain action

Біологічні студії, 2014
It is known that calix[4]arene with cipher C-99 selectively and with high affinity capable of inhibiting the Na+, K+-ATPase (compared with a known inhibitor of this enzyme – ouabain) of smooth muscle cells plasma membrane preparations.
O. V. Tsymbalyuk
doaj   +1 more source

Is Ouabain Produced by the Adrenal Gland?

General Pharmacology: The Vascular System, 1998
1. Ouabain or a related stereoisomer, termed endogenous ouabain, has been identified in adrenal cortex tissue and culture medium from adrenocortical cells. 2. Angiotensin II and adrenocorticotropin, the main activators of aldosterone secretion from adrenal glomerulosa cells appear to increase the production of this compound. 3.
Foster, Richard H., Prat Martorell, Hernán, Rothman, Ilan   +2 more
openaire   +4 more sources

Propionic Acidemia‐Induced Proarrhythmic Electrophysiological Alterations in Human iPSC‐Derived Cardiomyocytes

Journal of Inherited Metabolic Disease, Volume 48, Issue 3, May 2025.
ABSTRACT Propionic acidemia (PA) is a metabolic disorder caused by a deficiency of the mitochondrial enzyme propionyl‐CoA carboxylase (PCC) due to mutations in the PCCA or PCCB genes, which encode the two PCC subunits. PA may lead to several types of cardiomyopathy and has been linked to cardiac electrical abnormalities such as QT interval prolongation,
Anabel Cámara‐Checa, Mar Álvarez, Josu Rapún, Sara Pérez‐Martín, Roberto Núñez‐Fernández, Marcos Rubio‐Alarcón, Teresa Crespo‐García, Lourdes R. Desviat, Eva Delpón, Ricardo Caballero, Eva Richard   +10 more
wiley   +1 more source

Na+, K+-ATPase inhibition induces neuronal cell death in rat hippocampal slice cultures: Association with GLAST and glial cell abnormalities

Journal of Pharmacological Sciences, 2018
Na+, K+-ATPase is a highly expressed membrane protein. Dysfunction of Na+, K+-ATPase has been implicated in the pathophysiology of several neurodegenerative and psychiatric disorders, however, the underlying mechanism of neuronal cell death resulting ...
Yuki Kurauchi, Kazuki Noma, Akinori Hisatsune, Takahiro Seki, Hiroshi Katsuki   +4 more
doaj   +1 more source

Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD

Journal of Neuroinflammation
There is an intrinsic relationship between psychiatric disorders and neuroinflammation, including bipolar disorder. Ouabain, an inhibitor of Na+/K+-ATPase, has been implicated in the mouse model with manic-like behavior. However, the molecular mechanisms
Tzu-Yun Wang, Eddie Feng-Ju Weng, Yun-Chen Hsu, Lu-Ping Shiu, Teng-Wei Huang, Hsuan-Cheng Wu, Jau-Shyong Hong, Shao-Ming Wang   +7 more
doaj   +1 more source

Ouabain inhibition of Na/K-ATPase across the retina prevents signed refractive compensation to lens-induced defocus, but not default ocular growth in young chicks [v1; ref status: indexed, http://f1000r.es/rt]

F1000Research, 2013
Purpose: The relevance of retinal integrity and energy pathways to ocular growth and induction of refractive errors has seldom been investigated. Thus, we used ouabain to target the channels that are essential for the maintenance of membrane potentials ...
Melanie J Murphy, Sheila Gillard Crewther   +1 more
doaj   +1 more source