Results 71 to 80 of about 38,478 (200)

Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD

Journal of Neuroinflammation
There is an intrinsic relationship between psychiatric disorders and neuroinflammation, including bipolar disorder. Ouabain, an inhibitor of Na+/K+-ATPase, has been implicated in the mouse model with manic-like behavior. However, the molecular mechanisms
Tzu-Yun Wang, Eddie Feng-Ju Weng, Yun-Chen Hsu, Lu-Ping Shiu, Teng-Wei Huang, Hsuan-Cheng Wu, Jau-Shyong Hong, Shao-Ming Wang   +7 more
doaj   +1 more source

Na+, K+-ATPase inhibition induces neuronal cell death in rat hippocampal slice cultures: Association with GLAST and glial cell abnormalities

Journal of Pharmacological Sciences, 2018
Na+, K+-ATPase is a highly expressed membrane protein. Dysfunction of Na+, K+-ATPase has been implicated in the pathophysiology of several neurodegenerative and psychiatric disorders, however, the underlying mechanism of neuronal cell death resulting ...
Yuki Kurauchi, Kazuki Noma, Akinori Hisatsune, Takahiro Seki, Hiroshi Katsuki   +4 more
doaj   +1 more source

Involvement of Inflammatory Cytokines in Antiarrhythmic Effects of Clofibrate in Ouabain-Induced Arrhythmia in Isolated Rat Atria

Advances in Pharmacological Sciences, 2016
Considering the cardioprotective and anti-inflammatory properties of clofibrate, the aim of the present experiment was to investigate the involvement of local and systemic inflammatory cytokines in possible antiarrhythmic effects of clofibrate in ouabain-
Somayeh Moradi, Vahid Nikoui, Muhammad Imran Khan, Shayan Amiri, Farahnaz Jazaeri, Azam Bakhtiarian   +5 more
doaj   +1 more source

Ouabain triggers preconditioning through activation of the Na+,K+-ATPase signaling cascade in rat hearts [PDF]

, 2006
S. Pierre, C. Yang, Z. Yuan, J SEMINERIO, Mouas C, K Garlid, P. Dos-Santos, Z. Xie, S. Pierre, C. Yang, Z. Yuan, J SEMINERIO, Mouas C, K Garlid, Z. Xie   +14 more
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Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling.

PLoS ONE, 2019
It was shown previously that inhibition of the ubiquitous α1 isoform of Na+,K+-ATPase by ouabain sharply affects gene expression profile via elevation of intracellular [Na+]i/[K+]i ratio.
Larisa V Smolyaninova, Alexandra A Shiyan, Leonid V Kapilevich, Alexander V Lopachev, Tatiana N Fedorova, Tatiana S Klementieva, Aleksey A Moskovtsev, Aslan A Kubatiev, Sergei N Orlov   +8 more
doaj   +1 more source

Pharmacological analysis of the regulatory mechanisms of sperm hyperactivation by ouabain

, 2021
Gen L. Takei
openalex   +2 more sources

Protein Carbonylation of an Amino Acid Residue of the Na/K‐ATPase α1 Subunit Determines Na/K‐ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Background We have demonstrated that cardiotonic steroids, such as ouabain, signaling through the Na/K‐ATPase, regulate sodium reabsorption in the renal proximal tubule.
Yanling Yan, Anna P. Shapiro, Brahma R. Mopidevi, Muhammad A. Chaudhry, Kyle Maxwell, Steven T. Haller, Christopher A. Drummond, David J. Kennedy, Jiang Tian, Deepak Malhotra, Zi‐jian Xie, Joseph I. Shapiro, Jiang Liu   +12 more
doaj   +1 more source

Overexpression of the Na⁺/Ca²⁺ exchanger influences ouabain‐mediated spontaneous Ca²⁺ activity but not positive inotropy [PDF]

, 2018
Nils Bögeholz, Paul Pauls, Bastian K. Bauer, Jan S. Schulte, Gerrit Frommeyer, Dirk G. Dechering, Peter Boknik, Uwe Kirchhefer, Frank U. Müller, Christian Pott, Lars Eckardt, Nils Bögeholz, Paul Pauls, Bastian K. Bauer, Jan S. Schulte, Gerrit Frommeyer, Dirk G. Dechering, Peter Boknik, Uwe Kirchhefer, Frank U. Müller, Christian Pott, Lars Eckardt   +21 more
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Saturation transfer EPR measurements of the rotational motion of a strongly immobilized ouabain spin label on renal Na, K‐ATPase [PDF]

, 1990
James E. Mahaney, Jaymee P. Girard, Charles M. Grisham, James E. Mahaney, Jaymee P. Girard, Charles M. Grisham   +5 more
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Imipramine induces hyperactivity in rats pretreated with ouabain: Implications to the mania switch induced by antidepressants [PDF]

, 2021
Valvassori, Samira S., Cararo, José H., Marino, Carlos Augusto P., Possamai-Della, Taise, Ferreira, Camila L., Aguiar-Geraldo, Jorge M., Dal-Pont, Gustavo C., Quevedo Joao, Valvassori, Samira S., Cararo, José H., Marino, Carlos Augusto P., Possamai-Della, Taise, Ferreira, Camila L., Aguiar-Geraldo, Jorge M., Dal-Pont, Gustavo C., Quevedo Joao   +15 more
openalex   +1 more source