Results 31 to 40 of about 10,882,011 (287)

How to address the challenges of evaluating treatment benefits-risks in rare diseases? A convergent mixed methods approach applied within a Merkel cell carcinoma phase 2 clinical trial

open access: yesOrphanet Journal of Rare Diseases, 2018
Background Demonstrating treatment benefits within clinical trials in the context of rare diseases is often methodologically and practically challenging. Mixed methods research offers an approach to overcome these challenges by combining quantitative and
Murtuza Bharmal   +6 more
doaj   +1 more source

The unpredictably eruptive dynamics of spruce budworm populations in eastern Canada

open access: yesPopulation Ecology, EarlyView.
We examine historical population data for spruce budworm from several locations through the period 1930–1997, and use density‐dependent recruitment curves to test whether the pattern of population growth over time is more consistent with Royama's (1984; Ecological Monographs 54:429–462) linear R(t) model of harmonic oscillation at Green River New ...
Barry J. Cooke, Jacques Régnière
wiley   +1 more source

Validation of the 5-domain Niemann-Pick type C Clinical Severity Scale

open access: yesOrphanet Journal of Rare Diseases, 2021
Background Niemann-Pick disease type C (NPC) is an ultra-rare, progressive, genetic disease leading to impaired lysosomal function and neurodegeneration causing serious morbidity and shortened life expectancy.
Marc C. Patterson   +8 more
doaj   +1 more source

Network topology drives population temporal variability in experimental habitat networks

open access: yesPopulation Ecology, EarlyView.
Habitat patches connected by dispersal pathways form habitat networks. We explored how network topology affects population outcomes in laboratory experiments using a model species (Daphnia carinata). Central habitat nodes in complex lattice networks exhibited lower temporal variability in population sizes, suggesting they support more stable ...
Yiwen Xu   +3 more
wiley   +1 more source

Costs, outcomes, and cost-effectiveness of ovc interventions [PDF]

open access: yes, 2010
This item is archived in the repository for materials published for the USAID supported Orphans and Vulnerable Children Comprehensive Action Research Project (OVC-CARE) at the Boston University Center for Global Health and Development.More than 1 out of ...
Larson, Bruce
core   +1 more source

Development of the Philippine National Unified Health Research Agenda 2023–2028

open access: yesDiscover Public Health
Background Effective health research priority-setting (RPS) is essential for directing resources toward the most pressing health challenges and ensuring that research efforts are aligned with national and global health goals.
Reneepearl Kim Sales   +8 more
doaj   +1 more source

Establishing clinically meaningful within-individual improvement thresholds for eight patient-reported outcome measures in people with relapsing-remitting multiple sclerosis

open access: yesJournal of Patient-Reported Outcomes, 2023
Background As disease-modifying therapies do not reverse the course of multiple sclerosis (MS), assessment of therapeutic success involves documenting patient-reported outcomes (PROs) concerning health-related quality of life, disease and treatment ...
Nupur Greene   +7 more
doaj   +1 more source

Decoherence and definite outcomes [PDF]

open access: yes, 2012
This thesis has three aims: (1) to clarify in detail the relation between the decoherence mechanism and the problem of definite outcomes, (2) to dispel common misconceptions about the measurement problem in quantum mechanics, and (3) to present some ...
Colanero, Klaus
core   +1 more source

Geographic variation in walking activity in the red flour beetle Tribolium castaneum

open access: yesPopulation Ecology, EarlyView.
This study examined whether there is geographic variation in field populations, focusing on the moving activity in the red flour beetle Tribolium castaneum. Results showed significant differences in moving activity among field populations but no correlation with latitude or meteorological factors.
Kentarou Matsumura
wiley   +1 more source

Behavioural outcomes and psychopathology during adolescence [PDF]

open access: yes, 2013
Preterm birth is associated with a high risk of residual neurodevelopmental disability and cognitive impairment. These problems are closely associated with psychiatric disorders and thus it is unsurprising that preterm birth also confers high risk for ...
Johnson, Samantha J., Wolke, Dieter
core   +1 more source

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