Results 221 to 230 of about 128,146 (288)

The fc fragment of IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement‐dependent cytotoxicity

The FEBS Journal, EarlyView.
Multimeric IgM‐fragment crystallizable region (Fc) fragments retain the ability to bind C1q and initiate the classical complement pathway, leading to C4 activation and deposition in vitro. However, the Fc cores can also inhibit complement‐dependent cytotoxicity by competing with surface‐bound antibodies for C1q engagement.
Andrea J. Pinto, Anne Chouquet, Isabelle Bally, Véronique Rossi, Nicole M. Thielens, Chantal Dumestre‐Pérard, Renate Kunert, Christine Gaboriaud, Wai Li Ling, Jean‐Baptiste Reiser   +9 more
wiley   +1 more source

Mixed granulocytic airway inflammation impairs aversive learning and alters neuroimmune biomarkers in mice. [PDF]

Sci Rep
Morera PMA, Beserra-Filho JIA, Soares-Silva B, Lambertucci RH, de Queiroz VC, Pinheiro-Menegasso NM, da Silva RC, Ponci V, Oliveira MA, Tavares-de-Lima W, Lago JHG, Ribeiro AM, Prado CM.   +12 more
europepmc   +1 more source

Dual-function peptides derived from egg white ovalbumin: Bioinformatics identification with validation using in vitro assay

, 2019
Mohd Adam Salim Mohd Salim, Chee‐Yuen Gan   +1 more
openalex   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

Hydrogen inhalation ameliorates lung inflammation in mice with asthma. [PDF]

Eur J Med Res
Li H, Qi X, Xu H, Zhou R, Liu X, Li L, Hu C, Dai C.   +7 more
europepmc   +1 more source

Characterisation of a phylogenetically distinct PL25 family ulvan lyase from a seaweed biomass enriched metagenome

The FEBS Journal, EarlyView.
Ulvan is a polysaccharide available from green seaweed with beneficial properties for various applications. The full potential of ulvan requires enzymatic degradation of the polymer, thus producing ulvan oligosaccharides. This study expands the armoury of characterised ulvan lyases.
Andrius Jasilionis, Pavithra Sivakumar, Justyna M. Dobruchowska, Sune Fjermedal, Hörður Guðmundsson, Bjorn Thor Adalsteinsson, Guðmundur Ó. Hreggviðsson, Anne S. Meyer, Eva Nordberg Karlsson   +8 more
wiley   +1 more source

The Effect of Oleuropein on the Treatment of Allergic Rhinitis. [PDF]

Int Arch Otorhinolaryngol
Cil ÖÇ, Büyük B, Eroglu HA, Sehitoglu H.   +3 more
europepmc   +1 more source

Protective Effect of Oyaksoongi-San against Asthma Induced by Ovalbumin in a Mouse Model [PDF]

Jun‐Yeop Song, Eun Bok Baek, Eun-Ju Hong, Poornima Kumbukgahadeniya, Yu Jin Kim, Mee-Young Lee, Hyo‐Jung Kwun   +6 more
openalex   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Impact of Microplastic Exposure on Airway Inflammation in an Acute Asthma Murine Model. [PDF]

Tuberc Respir Dis (Seoul)
Choi JY, Hur J, Jo YS, Rhee CK.
europepmc   +1 more source