Results 241 to 250 of about 123,127 (337)

Skin‐Derived PGD2 Promotes Antigen‐Specific IgE Production via CRTH2 Signaling

open access: yes
Allergy, EarlyView.
Misato Kida   +5 more
wiley   +1 more source

N‐terminal helix formation and dimer–monomer transition of FGF10 in specific recognition of FGFR2b

open access: yesThe FEBS Journal, EarlyView.
FGF10 specifically recognizes FGFR2b with a conformational change of the N‐terminal part. The N‐terminal part of FGF10 and two loops of FGFR2b constituting the interaction interface are the most varied regions in FGF and FGFR family members. FGF10 shows a concentration‐dependent dimerization.
Hyunjae Park   +12 more
wiley   +1 more source

Adsorption of antigen to polymeric nanoparticles enhances cytotoxic T‐cell responses and anti‐tumor immunity by targeting conventional type 1 dendritic cells

open access: yesImmunology &Cell Biology, EarlyView.
Therapeutic cancer vaccines require CD8+ T‐cell activation for efficacy. This response can be enhanced by rationally designing polymeric nanoparticle adjuvants. The importance of antigen location for the adjuvanticity of polymeric nanoparticles has not been fully resolved.
Jorge Huete‐Carrasco   +6 more
wiley   +1 more source

Characterization of a prokaryotic topoisomerase I activity in chloroplast extracts of maize [PDF]

open access: yes, 1983
Siedlecki, Janusz   +2 more
core  

Germinal center formation is resilient to CD69 deletion on T follicular helper cells

open access: yesImmunology &Cell Biology, EarlyView.
CD69 is upregulated on human and mouse CD4+ T follicular helper (TFH) cells within the germinal center. In this article, we use an Il21‐cre mouse strain to ablate floxed Cd69 genes from TFH cells and a proportion of their precursors. We find that when TFH cells lack CD69, the germinal center response remains intact, supporting B‐cell affinity ...
Stephane M Guillaume   +6 more
wiley   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

open access: yesImmunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu   +24 more
wiley   +1 more source

Home - About - Disclaimer - Privacy