Биопрепараты: Профилактика, диагностика, лечение, 2022 The use of sulfated polysaccharides (fucoidans) as active pharmaceutical ingredients or adjuvants poses the challenge of obtaining structurally characterised and homogeneous samples or their oligomeric fractions maintaining high biological activity.
T. A. Kuznetsova +6 more
doaj +1 more source
Efficient production of human interferon beta in the white of eggs from ovalbumin gene–targeted hens
Scientific Reports, 2018 Transgenic chickens could potentially serve as bioreactors for commercial production of recombinant proteins in egg white. Many transgenic chickens have been generated by randomly integrating viral vectors into their genomes, but transgene expression has
Isao Oishi +3 more
semanticscholar +1 more source
Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome [PDF]
, 2007 Objective: Previous studies have shown the importance of somatic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies in human and murine lupus, and in studies of
Giles, I. +7 more
core +1 more source
Conformational Changes Involved in the Switch from Ovalbumin to S-Ovalbumin
Zeitschrift für Naturforschung C, 1996 Abstract For the first time a comparative study on conformational differences between native oval buminand its heat-stable form, called S-ovalbumin. using small angle x-ray scattering, is reported. To detect a different pathway in the folding mechanism of the two proteins, scattering measurements have been performed on ovalbumin and S ...
Castellano AC +5 more
openaire +4 more sources
Biodistribution of free 99mTc-ovalbumin and 99mTc-ovalbumin encapsulated in liposomes [PDF]
Brazilian Archives of Biology and Technology, 2005 The oral administration of proteic antigens, like ovalbumin, may result in the induction of oral tolerance or immunization. The aim of this work was to label a protein antigen with 99mTechnetium, encapsulate it in liposomes and investigate its absorption and tissue distribution after oral administration in mice. Ovalbumin was labeled with 99mTechnetium
Alves, Andrea Catão +6 more
openaire +6 more sources
Poultry Science, 2019 As the most abundant protein in chicken eggs, ovalbumin plays an important role in the processing of high value‐added poultry products. The present study investigated the effects of hydroxyl radical‐induced early stage oxidation on the physicochemical ...
Shu-gang Li +5 more
semanticscholar +1 more source
MHC class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity [PDF]
, 2014 Background—Plasmacytoid dendritic cells (pDCs) bridge innate and adaptive immune responses and are important regulators of immuno-inflammatory diseases. However, their role in atherosclerosis remains elusive.
Ait-Oufella, Hafid +16 more
core +2 more sources
Poly(2-propylacrylic acid)/poly(lactic-co-glycolic acid) blend microparticles as a targeted antigen delivery system to direct either CD4+ or CD8+ T cell activation. [PDF]
, 2017 Poly(lactic-co-glycolic acid) (PLGA) based microparticles (MPs) are widely investigated for their ability to load a range of molecules with high efficiency, including antigenic proteins, and release them in a controlled manner.
Bracho-Sanchez, Evelyn +6 more
core +1 more source
Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway [PDF]
, 2008 Substrates of a ubiquitin-dependent proteolytic system called the N-end rule pathway include proteins with destabilizing N-terminal residues. N-recognins, the pathway’s ubiquitin ligases, contain three substrate-binding sites. The type-1 site is specific
Du, Fangyong +5 more
core +3 more sources
CD8+ T cell memory is sustained in mice by hepatic stellate cells
Hepatology, EarlyView., 2022 HSC role in memory CD8+ T cell maintenance. Abstract Background and Aims Long‐lasting immunological memory is the ultimate goal of vaccination. Homeostatic maintenance of memory CD8+ cytotoxic T cells (MemCD8TCs) is thought to be mediated by IL‐15/IL‐15R heterodimer (15HD)‐expressing myeloid cells.
Yi‐Ting Chen +4 more
wiley +1 more source