Results 11 to 20 of about 153,874 (301)

Epithelial ovarian cancer: prevention, diagnosis, and treatment [PDF]

CA: A Cancer Journal for Clinicians, 1999
The leading cause of death from gynecologic malignancies in the United States is epithelial ovarian cancer. The significant risk factor for development of ovarian cancer is advancing age, although there is clearly a genetic predisposition--often associated with the BRCA1 and BRCA2 genes--in at least 5% to 10% of all epithelial ovarian cancers.
E E, Partridge, M N, Barnes
openaire   +4 more sources

ORGAVADS: establishment of tumor organoids from head and neck squamous cell carcinoma to assess their response to innovative therapies

BMC Cancer, 2023
Background Radiotherapy is one of the cornerstones of the treatment of Head and Neck Squamous Cell Carcinomas (HNSCC). However, radioresistance is associated with a high risk of recurrence.
Marion Perréard, Romane Florent, Jordane Divoux, Jean-Michel Grellard, Justine Lequesne, Mélanie Briand, Bénédicte Clarisse, Nathalie Rousseau, Esther Lebreton, Brice Dubois, Valentin Harter, Audrey Lasne-Cardon, Julien Drouet, Alisson Johnson, Anne-Laure Le Page, Céline Bazille, Corinne Jeanne, Martin Figeac, Nicolas Goardon, Dominique Vaur, Emmanuel Micault, Maxime Humbert, Juliette Thariat, Emmanuel Babin, Laurent Poulain, Louis-Bastien Weiswald, Vianney Bastit   +26 more
doaj   +1 more source

The TRIPLEX study: use of patient-derived tumor organoids as an innovative tool for precision medicine in triple-negative breast cancer

BMC Cancer, 2023
Background Triple negative breast cancers (TNBC) account for approximately 15% of all breast cancers and are associated with a shorter median survival mainly due to locally advanced tumor and high risk of metastasis. The current neoadjuvant treatment for
Jordane Divoux, Romane Florent, Margaux Jacobs, Justine Lequesne, Jean-Michel Grellard, Chankannira San, Sara Grossi, Katia Kerdja, Bénédicte Clarisse, Gwenaelle Boudier, François Cherifi, Mélanie Briand, Enora Dolivet, Alisson Johnson, Brice Dubois, Valentin Harter, Joëlle Lacroix, Charlotte Raboutet, Brigitte Marie, Nathalie Rousseau, Cécile Blanc-Fournier, Dominique Vaur, Martin Figeac, Laurent Poulain, Louis-Bastien Weiswald, George Emile   +25 more
doaj   +1 more source

Comparative analysis of response to treatments and molecular features of tumor-derived organoids versus cell lines and PDX derived from the same ovarian clear cell carcinoma

Journal of Experimental & Clinical Cancer Research, 2023
Background In the era of personalized medicine, the establishment of preclinical models of cancer that faithfully recapitulate original tumors is essential to potentially guide clinical decisions.
Lucie Thorel, Pierre-Marie Morice, Hippolyte Paysant, Romane Florent, Guillaume Babin, Cécilia Thomine, Marion Perréard, Edwige Abeilard, Florence Giffard, Emilie Brotin, Christophe Denoyelle, Céline Villenet, Shéhérazade Sebda, Mélanie Briand, Florence Joly, Enora Dolivet, Didier Goux, Cécile Blanc-Fournier, Corinne Jeanne, Marie Villedieu, Matthieu Meryet-Figuiere, Martin Figeac, Laurent Poulain, Louis-Bastien Weiswald   +23 more
doaj   +1 more source

Ovarian Cancer: From Precursor Lesion Identification to Population-Based Prevention Programs

Current Oncology, 2023
Epithelial ovarian cancer (EOC) is a heterogeneous group of malignancies, including high-grade serous ovarian cancer (HGSC). HGSC is often diagnosed at advanced stages and is linked to TP53 variants.
Ramlogan Sowamber, Alexandra Lukey, David Huntsman, Gillian Hanley   +3 more
doaj   +1 more source

Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1)

Scientific Reports, 2022
Physical activity (PA) helps prevention and aftercare of sporadic breast cancer (BC), cardiopulmonary fitness (CPF) being an age-independent predictor of tumor-specific mortality.
A. Berling-Ernst, M. Yahiaoui-Doktor, M. Kiechle, C. Engel, J. Lammert, S. Grill, R. Dukatz, K. Rhiem, F. T. Baumann, S. C. Bischoff, N. Erickson, T. Schmidt, U. Niederberger, M. Siniatchkin, M. Halle   +14 more
doaj   +1 more source

Research Progress of Estrogen Receptor in Ovarian Cancer

Clinical and Experimental Obstetrics & Gynecology, 2023
Objective: This review aims to provide some theoretical guidance for the precise treatment of ovarian cancer and the development of estrogen-related drugs.
Mengchen Zhang, Haohui Xu, Yixin Zhang, Zhanfei Li, Wenqiang Meng, Jiayi Xia, Wentao Lei, Kai Meng, Yan Guo   +8 more
doaj   +1 more source

Ovarian Cancer Prevention and Screening [PDF]

Obstetrics & Gynecology, 2018
There has been much progress in ovarian cancer screening and prevention in recent years. Improved tools that combine genetic and epidemiologic factors to predict an individual's ovarian cancer risk are set to become available for tailoring preventive and screening approaches.
Menon, U, Karpinskyj, CL, Gentry-Maharaj, A   +2 more
openaire   +3 more sources

Opportunistic bilateral salpingectomy (OBS) for the prevention of ovarian cancer should be offered in the context of a clinical trial: FOR: There is lack of clarity on a number of key issues. [PDF]

, 2016
Increasing evidence and acceptance of the role of the tube in the etiopathogenesis of ovarian cancer has led to opportunistic bilateral salpingectomy (OBS) being considered as an ovarian cancer prevention strategy for premenopausal women (who have ...
Manchanda, R, Menon, U
core   +2 more sources

Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise [PDF]

, 2011
The mechanism of chemotherapy-induced acceleration of ovarian aging is not fully understood. We used doxorubicin, a widely used cancer chemotherapeutic, in a variety of in vivo xenograft, and in vitro models to investigate the impact of chemotherapy ...
Darzynkiewicz, Zbigniew, Heytens, Elke, Oktay, Kutluk, Soleimani, Reza   +3 more
core   +1 more source