Results 31 to 40 of about 153,874 (301)

Progesterone prevents HGSOC by promoting precancerous cell pyroptosis via inducing fibroblast paracrine

open access: yesiScience, 2023
Summary: High-grade serous ovarian carcinoma (HGSOC) is one of the most fatal gynecological cancers and has no effective prevention strategies. Herein, we demonstrated that progesterone significantly inhibited the occurrence, metastasis, and ascites of ...
Nayiyuan Wu   +10 more
doaj   +1 more source

Research Progress of MicroRNA in Early Detection of Ovarian Cancer

open access: yesChinese Medical Journal, 2015
Objective: This review aimed to update the progress of microRNA (miRNA) in early detection of ovarian cancer. We discussed the current clinical diagnosis methods and biomarkers of ovarian cancer, especially the methods of miRNA in early detection of ...
Ze-Hua Wang, Cong-Jian Xu
doaj   +1 more source

Etiopathogenesis of ovarian cancer. An inflamm-aging entity?

open access: yesGynecologic Oncology Reports, 2022
Ovarian cancer is one of the most common gynecologic cancers and has the highest mortality rate. The risk/protective factors of ovarian cancer suggest that its etiology is multifactorial.
Manuel Sánchez-Prieto   +3 more
doaj   +1 more source

Preclinical evaluation of local prolonged release of paclitaxel from gelatin microspheres for the prevention of recurrence of peritoneal carcinomatosis in advanced ovarian cancer [PDF]

open access: yes, 2019
Patients with advanced ovarian cancer develop recurrence despite initial treatment response to standard treatment of surgery and intravenous/intraperitoneal (IP) chemotherapy, partly due to a limited peritoneal exposure time of chemotherapeutics ...
Ceelen, Wim   +7 more
core   +2 more sources

Peritoneal adhesions after laparoscopic gastrointestinal surgery [PDF]

open access: yes, 2014
Although laparoscopy has the potential to reduce peritoneal trauma and post-operative peritoneal adhesion formation, only one randomized controlled trial and a few comparative retrospective clinical studies have addressed this issue.
MAIS, VALERIO
core   +1 more source

Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis [PDF]

open access: yes, 2016
Despite the well-established tumor suppressive role of TGFβ proteins, depletion of key TGFβ signaling components in the mouse ovary does not induce a growth advantage.
Bartholin, Laurent   +5 more
core   +1 more source

Migraine, headache, and mortality in women: a cohort study [PDF]

open access: yes, 2020
Background: Migraine carries a high global burden, disproportionately affects women, and has been implicated as a risk factor for cardiovascular disease. Migraine with aura has been consistently associated with increased risk of cardiovascular mortality.
Buring, Julie Elizabeth   +3 more
core   +1 more source

Prophylactic Oophorectomy in Ovarian Cancer Prevention

open access: yesObstetrical & Gynecological Survey, 1996
To evaluate prophylactic oophorectomy in the prevention of ovarian cancer.Between 1970 and 1990, 5262 hysterectomies were performed at Areteion Hospital, Athens.Ovarian cancer was subsequently diagnosed in 520 women (9.9%). The mean interval from hysterectomy to diagnosis of ovarian cancer was 7.2 years.
Kontoravdis, A   +5 more
openaire   +3 more sources

Preventing Ovarian Cancer by Salpingectomy

open access: yesCurrent Oncology, 2013
This issue of Current Oncology contains four articles1–4 on the subject of the role of bilateral salpingectomy in preventing high-grade serous ovarian carcinoma.[...]
openaire   +2 more sources

Targeting progesterone signaling prevents metastatic ovarian cancer [PDF]

open access: yesProceedings of the National Academy of Sciences, 2020
SignificanceWhy women carrying a pathogenic germlineBRCA1mutation are predisposed to ovarian and breast cancer remains elusive. This study points to ovarian progesterone as a culprit. Generally,BRCA1-mutation carriers exhibit high yet individually varying levels of progesterone during the menstrual cycle. Although not allBRCA1-mutation carriers develop
Kim, Olga   +21 more
openaire   +2 more sources

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