Results 81 to 90 of about 5,436,969 (234)

Assessing Metabolic and Reproductive Consequences of Prenatal Paracetamol Exposure in Female CD1 Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Paracetamol is a widely used analgesic during pregnancy; however, emerging evidence suggests it may act as an endocrine/metabolism disrupting compound. Using an F1 female CD1 mouse model, this study scrutinized the long‐term metabolic and reproductive consequences linked to intrauterine paracetamol exposure.
Bita Entezari, Deniz Bozdag, Elif İnce‐Erguc, Aylin Buhur, Cansin Sirin Tomruk, Suna Sabuncuoglu, Altug Yavasoglu, Hande Gurer‐Orhan   +7 more
wiley   +1 more source

Exploring the Reproductive Toxicity of Bisphenol S Through a Network Toxicology and Molecular Docking Analysis

Pediatric Discovery, EarlyView.
Utilizing network toxicology, molecular docking, and dynamic simulations to investigate the potential reproductive toxicity of bisphenol S (BPS). ABSTRACT The aim of this study was to investigate the potential reproductive toxicity of bisphenol S (BPS) and the related molecular mechanisms through a network toxicology approach.
Siyuan Wang, Yan Fu, Xu Huang, Qitong Guo, Xiangqin Zheng, Shengde Wu, Lianju Shen, Guanghui Wei   +7 more
wiley   +1 more source

Cangfu Daotan Wan alleviates polycystic ovary syndrome with phlegm-dampness syndrome via disruption of the PKP3/ERCC1/MAPK axis

Journal of Ovarian Research, 2023
Background/Aim Cangfu Daotan Wan (CFDTW) has been widely used for polycystic ovary syndrome (PCOS) patients in the type of stagnation of phlegm and dampness.
Yuan Li, Haicui Wu, Ying Guo, Chaofeng Wei, Lu Guan, Wenhan Ju, Fang Lian   +6 more
doaj   +1 more source

CACNA2D1 promotes ovulation by regulating ovarian immune cell infiltration

BMC Veterinary Research
Background In the previous single-cell transcriptome analysis of goat ovulation, we identified that CACNA2D1 may play a critical role in immune cell infiltration during the ovulation process.
Conghui Guo, Jie Liu, Kaihao Chen, Guangbin Liu, Dewu Liu, Yaokun Li   +5 more
doaj   +1 more source

Risk of Cancer With Hormone Replacement Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Hormone replacement therapy (HRT) remains the cornerstone of menopausal symptom management, effectively alleviating vasomotor symptoms and genitourinary syndrome, whilst mitigating long‐term risks such as osteoporosis. However, despite an increasing body of evidence on the relative safety of HRT, earlier studies that demonstrated an increased ...
Gabriella Yongue, Zachary Nash, Vikram Talaulikar, Shibani Nicum   +3 more
wiley   +1 more source

Ovarian follicle selection and granulosa cell differentiation

Poultry Science, 2015
The reproductive strategy for avian species that produce a sequence (or clutch) of eggs is dependent upon the maintenance of a small cohort of viable, undifferentiated (prehierarchal) follicles. It is from this cohort that a single follicle is selected on an approximate daily basis to initiate rapid growth and final differentiation before ovulation ...
openaire   +2 more sources

hAECs restore follicular development in premature ovarian insufficiency via IGFBP2/IGF1R-mediated intercellular communication

Stem Cell Research & Therapy
Background Premature ovarian insufficiency (POI) is defined by ovarian dysfunction and consequent decreased fertility. While follicular depletion is an acknowledged factor, dynamic changes in follicular subpopulations and single-cell-level niche ...
Wenjiao Cao, Lu Shen, Qinyu Zhang, Yating Huang, Junyan Sun, Zixin Cheng, Jing Xu, Qiuwan Zhang, Dongmei Lai   +8 more
doaj   +1 more source

Ovarian Collagen Regulates Granulosa Cell Proliferation Through Persistent Activation of the ERK1/2 Pathway in the Chinese Soft-Shelled Turtle (Pelodiscus sinensis)

Animals
The Chinese soft-shelled turtle (Pelodiscus sinensis) is an important aquaculture species in China, and proper follicular development is crucial for its reproduction.
Xinqi Han, Yin Guo, Xiuyan Lou, Yanyan Zhang, Senhao Jiang, Chutian Ge, Ling Xiao   +6 more
doaj   +1 more source

Peroxiredoxin 4 protects against ovarian ageing by ameliorating d-galactose-induced oxidative damage in mice

Cell Death and Disease, 2020
Peroxiredoxin 4 (Prdx4), a member of the Prdx family, is a vital ER-resident antioxidant in cells. As revealed in our previous study, Prdx4 expression was detected in ovarian granulosa cells and was closely related to ovarian function.
Xiuru Liang, Zhengjie Yan, Weiwei Ma, Yi Qian, Xiaofei Zou, Yugui Cui, Jiayin Liu, Yan Meng   +7 more
doaj   +1 more source

Ovarian Thecal Cells Produce Transforming Growth Factor-β Which Can Regulate Granulosa Cell Growth

, 1987
Ovarian thecal cells in culture were found to synthesize and secrete transforming growth factor-β (TGFβ). A component in thecal cell-conditioned medium was immunologically similar to TGFβ, as assessed with a RIA, and inhibited specific binding of TGFβ to
Skinner, MICHAEL K., Moses, HAROLD L., KESKI-OJA, JORMA, Osteen, KEVIN G., KEVIN G. OSTEEN, MICHAEL K. SKINNER, HAROLD L. MOSES, JORMA KESKI-OJA   +7 more
core   +1 more source