Results 61 to 70 of about 10,574,592 (282)

Comparison of Reinforcement Learning and Model Predictive Control for Automated Generation of Optimal Control for Dynamic Systems within a Design Space Exploration Framework

International Journal of Automotive Engineering
This work provides a study of methods for the automated derivation of control strategies for over-actuated systems. For this purpose, Reinforcement Learning (RL) and Model Predictive Control (MPC) approximating the solution of the Optimal Control Problem
Patrick Hoffmann, Kirill Gorelik, Valentin Ivanov   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Reconfigurable fault-tolerant attitude control for over-actuated hypersonic flight vehicle with actuator failures

Alexandria Engineering Journal
This paper proposes a novel fast attitude fault-tolerant control (FTC) scheme for over-actuated hypersonic flight vehicles experiencing actuator failures, such as stuck faults and loss of effectiveness faults. The FTC scheme comprises two main components:
Ao Li, Xiaoxiang Hu, Kejun Dong, Hongzeng Li, Bing Xiao   +4 more
doaj   +1 more source

Development and Experiments of an Electrothermal Driven Deep-Sea Buoyancy Control Module

Micromachines, 2020
Due to the extremely high pressures in the deep sea, heavy ballast tanks and pressure compensating hydraulic tanks are typically required to support the operation of classic buoyancy controls.
Jiaoyi Hou, Weifeng Zou, Zihao Li, Yongjun Gong, Vitalii Burnashev, Dayong Ning   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Realisation of a Novel Functionally Redundant Actuation System for a Railway Track-Switch

Applied Sciences, 2021
This paper focuses on modelling, control, realisation and performance analysis of a full-scale demonstrator for a novel railway track switch. For over a century, railway track switches (or points) have been allowing trains to safely change between routes.
Osama Olaby, Saikat Dutta, Tim Harrison, Christopher P. Ward, Roger Dixon   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Control Allocation Approach Using Differential Steering to Compensate for Steering Actuator Failure

IEEE Open Journal of Intelligent Transportation Systems
Wheel-selective drives on the steered axle of a vehicle with Ackermann steering allow for the generation of steering torque without the use of a steering actuator.
Alexander Seiffer, Michael Frey, Frank Gauterin   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source