Oxidized LDL triggers pro-oncogenic signaling in human breast mammary epithelial cells partly via stimulation of MiR-21. [PDF]
PLoS ONE, 2012 Dyslipidemia and obesity are primary risk factors for the development of atherosclerosis and are also epidemiologically linked to increased susceptibility to a variety of cancers including breast cancer.
Magomed Khaidakov, Jawahar L Mehta
doaj +1 more source
Atherosclerosis Initiation Modeled as an Inflammatory Process [PDF]
, 2015 In this work we study the inflammatory process resulting in the development of atherosclerosis. We develop a one- and two-dimensional models based on reaction-diffusion systems to describe the set up of a chronic inflammatory response in the intima of an
El Khatib, N., Genieys, S., Volpert, V.
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HMGB1 promotes Ox-LDL-induced endothelial cell damage by inhibiting PI3K/Akt signaling pathway
BMC Cardiovascular Disorders, 2022 Background Atherosclerosis is the pathological basis of cardio-cerebrovascular diseases. Oxidized low-density lipoprotein (ox-LDL) is an important risk factor for atherosclerosis.
Xin Huo +3 more
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Membrane cholesterol modulates LOX-1 shedding in endothelial cells [PDF]
, 2015 The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor responsible for ox-LDL recognition, binding and internalization, which is up-regulated during atherogenesis.
Biocca, S +6 more
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The FASEB Journal, 2010 Atherosclerosis is inflammatory in nature and oxidized low density lipoprotein (ox‐LDL) has activating effects on vascular smooth muscle cells (VSMC). Interleukin‐19 (IL‐19) is a recently described Th2 anti‐inflammatory cytokine.
Anthony A. Cuneo +2 more
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Infectious agents in atherosclerotic cardiovascular diseases through oxidative stress [PDF]
, 2017 Accumulating evidence demonstrates that vascular oxidative stress is a critical feature of atherosclerotic process, potentially triggered by several infectious agents that are considered as risk co-factors for the atherosclerotic cardiovascular diseases (
Di Pietro, M +4 more
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MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. [PDF]
, 2014 Low-grade systemic inflammation is often associated with metabolic syndrome, which plays a critical role in the development of the obesity-associated inflammatory diseases, including insulin resistance and atherosclerosis.
DeFranco, Anthony L +19 more
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The FASEB Journal, 2008 The causal relationship of the hypertension associated with metabolic syndrome and diabetes mellitus (NIDDM) is unknown. Elevated OX‐LDL, characteristic of NIDDM causes dose‐dependent arterial muscle contraction but the signaling pathway is not understood. The OX‐LDL receptor (LOX1) has been identified on arterial smooth muscle but its role is unknown.
Erin C. Odya +5 more
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Apremilast ameliorates ox-LDL-induced endothelial dysfunction mediated by KLF6
Aging, 2020 Apremilast is a phosphodiesterase 4 (PDE4) inhibitor used in the treatment of psoriasis and several other inflammatory diseases. Interest has been expressed in seeking out therapies that address both psoriasis and atherosclerosis. In the present study, we explored the effects of apremilast in human aortic endothelial cells (HAECs) exposed to oxidized ...
Wang, Hao +7 more
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Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects [PDF]
, 2015 Extra virgin olive oil (EVOO) is a key component of the Mediterranean diet and seems to account for the protective effect against cardiovascular disease.
ANGELICO, Francesco +10 more
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