Results 21 to 30 of about 259,578 (273)

Autophagy blockage promotes the pyroptosis of ox-LDL-treated macrophages by modulating the p62/Nrf2/ARE axis

Journal of physiology and biochemistry, 2021
Atherosclerosis, a chronic comprehensive cardiovascular disease, is characterized by the lipid infiltration, formation of foam cells derived from macrophages and inflammation in the vessel wall.
Jiaru Liu, Chao Wang, Jiashan Li, Ying-li Yu, Yue Liu, Huihui Liu, Qi Peng, Xiuru Guan   +7 more
semanticscholar   +1 more source

Rapamycin Inhibits Oxidized Low Density Lipoprotein Uptake in Human Umbilical Vein Endothelial Cells via mTOR/NF-κB/LOX-1 Pathway. [PDF]

PLoS ONE, 2016
Lectin-like oxidized low-density lipoprotein-1 (LOX-1) is the major receptor for oxidized low density lipoprotein (ox-LDL) uptake in human umbilical vein endothelial cells (HUVECs).
Yan-De Zhou, Xue-Qin Cao, Zhi-Hua Liu, Yong-Jun Cao, Chun-Feng Liu, Yan-Lin Zhang, Ying Xie   +6 more
doaj   +1 more source

Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis

Aging, 2020
Long noncoding RNAs (lncRNAs) play important roles in the development of vascular diseases. However, the effect of lncRNA NORAD on atherosclerosis remains unknown.
Weihua Bian, Xiaohong Jing, Zhiyu Yang, Zhen Shi, Ruiyao Chen, Ai-li Xu, Na Wang, Jing Jiang, Cheng Yang, Daolai Zhang, Lan Li, Haiyan Wang, Juan Wang, Yeying Sun, Chunxiang Zhang   +14 more
semanticscholar   +1 more source

Proprotein Convertase Subtilisin Kexin Type 9 Inhibitors Reduce Platelet Activation Modulating ox-LDL Pathways

International Journal of Molecular Sciences, 2021
Background: Proprotein convertase subtilisin kexin type 9 inhibitors (PCSK9i) lower LDL-cholesterol and slow atherosclerosis preventing cardiovascular events.
V. Cammisotto, F. Baratta, Valentina Castellani, S. Bartimoccia, C. Nocella, L. D’Erasmo, N. Cocomello, C. Barale, Roberto Scicali, A. Di Pino, S. Piro, M. del Ben, M. Arca, I. Russo, F. Purrello, R. Carnevale, F. Violi, D. Pastori, P. Pignatelli   +18 more
semanticscholar   +1 more source

circ_0003204 Regulates Cell Growth, Oxidative Stress, and Inflammation in ox-LDL-Induced Vascular Endothelial Cells via Regulating miR-942-5p/HDAC9 Axis

Frontiers in Cardiovascular Medicine, 2021
Background: Atherosclerosis (AS) is a typical inflammatory vascular disease. Many reports corroborated that circular RNAs (circRNAs) is involved in AS progression.
Huan Wan, Ting You, W. Luo
semanticscholar   +1 more source

Accumulation of LDL/ox-LDL in the necrotic region participates in osteonecrosis of the femoral head: a pathological and in vitro study

Lipids in Health and Disease, 2021
Background Osteonecrosis of the femoral head (ONFH) is a common but intractable disease that appears to involve lipid metabolic disorders. Although numerous studies have demonstrated that high blood levels of low-density lipoprotein (LDL) are closely ...
Xin-Yuan Wang, Tian-Le Ma, Kang-Ning Chen, Zhi-Ying Pang, Hao Wang, Jun-Ming Huang, Guo-Bin Qi, Chen-Zhong Wang, Zeng-Xin Jiang, Lin-Jing Gong, Zhe Wang, Chang Jiang, Zuo-Qin Yan   +12 more
doaj   +1 more source

Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway

Journal of Immunological Research, 2021
Uric acid is an effective antioxidant. Oxidized low-density lipoprotein (ox-LDL) is derived from circulating LDL and promotes atherosclerosis. The Keap1-Nrf2-ARE pathway is a key body pathway involved in protection against internal and external oxidative
Yajuan Lin, Yun-jie Xie, Zhujing Hao, Hai-Lian Bi, Yang Liu, Xiaolei Yang, Yunlong Xia   +6 more
semanticscholar   +1 more source

Oxidized low density lipoprotein-mediated activation of phospholipase D in smooth muscle cells: a possible role in cell proliferation and atherogenesis.

Journal of Lipid Research, 1995
Low density lipoproteins (LDL) are risk factors in atherosclerosis and oxidative modification of LDL to oxidized LDL (OX-LDL) increases its atherogenicity.
V Natarajan, W M Scribner, C M Hart, S Parthasarathy   +3 more
doaj   +1 more source

Bilirubin is independently associated with oxidized LDL levels in young obese patients [PDF]

, 2015
BACKGROUND: Bilirubin can prevent lipid oxidation in vitro, but the association in vivo with oxidized low-density lipoprotein (Ox-LDL) levels has been poorly explored.
Aires, L., Alves, A., Belo, L., Bronze-da-Rocha, E., Catarino, C., Coimbra, S., Costa, E., Gomes, D., Mansilha, H., Mota, J., Nascimento, H., Rocha-Pereira, P., Rêgo, C., Santos-Silva, A.   +13 more
core   +2 more sources

Apolipoprotein-J blocks increased cell injury elicited by ox-LDL via inhibiting ROS-CaMKII pathway

Lipids in Health and Disease, 2019
Background Oxidized low-density lipoprotein (ox-LDL) is crucial in cardiac injury. Apolipoprotein-J (ApoJ) contributes to antiapoptotic effects in the heart.
Yanzhuo Ma, Zhi Gong, Kai Nan, Shuying Qi, Yu Chen, Chao Ding, Dongmei Wang, Leisheng Ru   +7 more
doaj   +1 more source