Results 31 to 40 of about 259,578 (273)

Melatonin Attenuates ox-LDL-Induced Endothelial Dysfunction by Reducing ER Stress and Inhibiting JNK/Mff Signaling

Oxidative Medicine and Cellular Longevity, 2021
Endothelial dysfunction, which is characterized by damage to the endoplasmic reticulum (ER) and mitochondria, is involved in a variety of cardiovascular disorders.
Peng Li, Changlian Xie, Jiankai Zhong, Zhongzhou Guo, Kai Guo, Qiuyun Tu   +5 more
semanticscholar   +1 more source

Ox-LDL Aggravates the Oxidative Stress and Inflammatory Responses of THP-1 Macrophages by Reducing the Inhibition Effect of miR-491-5p on MMP-9

Frontiers in Cardiovascular Medicine, 2021
Background: Oxidized low-density lipoprotein (ox-LDL) can induce oxidative stress and inflammatory responses in macrophages to facilitate the genesis and development of atherosclerosis. However, the intermediate links remain unclear.
Yi-Ching Liao, Enzheng Zhu, Wanxing Zhou
semanticscholar   +1 more source

Role of ox-LDL immunocomplexes in diabetic retinopathy

Canadian Journal of Diabetes, 2009
Canadian Journal of Diabetes 33 (2009) 222-223.
University of Oklahoma Health Sciences Center, Medicine, Oklahoma City, USA ( host institution ), Wu, M., Chen, Y., Abdel-samie, S.A., Wilson, K., Boulton, M.E., Ma, J.X., Virella, G., Lopes-Virella, M.F., Lyons, T.J.   +9 more
openaire   +2 more sources

Ceramide mediates Ox-LDL-induced human vascular smooth muscle cell calcification via p38 mitogen-activated protein kinase signaling. [PDF]

PLoS ONE, 2013
Vascular calcification is associated with significant cardiovascular morbidity and mortality, and has been demonstrated as an actively regulated process resembling bone formation.
Lizhen Liao, Qin Zhou, Yan Song, Weikang Wu, Huimin Yu, Sheng Wang, Yanling Chen, Meihong Ye, Lihe Lu   +8 more
doaj   +1 more source

Design of a novel LOX-1 receptor antagonist mimicking the natural substrate [PDF]

, 2013
The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), the major receptor for oxidized low-density lipoprotein (ox-LDL) in endothelial cells, is overexpressed in atherosclerotic lesions.
Biocca, S, Ciccone, S, D'Arrigo, P, Desideri, A, Falconi, M, Novelli, G, Patrizi, P, Sorge, R, Viani, F   +8 more
core   +1 more source

Azilsartan ameliorates ox-LDL-induced endothelial dysfunction via promoting the expression of KLF2

Aging, 2021
Background: Oxidized LDL(Ox-LDL) mediated endothelial dysfunction is involved in the pathogenesis of various cardiovascular diseases, including atherosclerosis.
Wenfeng Li, Cheng-guo Wang, Dandan Zhang, Kanghua Zeng, Shihui Xiao, F. Chen, Jun Luo   +6 more
semanticscholar   +1 more source

Relationship of the oxidized low‐density lipoprotein (OX‐LDL) receptor, LOX1, to OX‐LDL reactivity of various arterial muscles

The FASEB Journal, 2007
Hypertension is associated with metabolic syndrome and diabetes mellitus (NIDDM) although the causal relationship is unknown. Elevated OX‐LDL is characteristic of NIDDM. OX‐LDL causes dose‐dependent arterial muscle contraction but the signaling pathway is not understood.
Maria H Dominguez, Ami E Rice, Elmer T Sanders, Connie J Temm, C Subah Packer   +4 more
openaire   +1 more source

Immune complex formation in human diabetic retina enhances toxicity of oxidized LDL towards retinal capillary pericytes1

Journal of Lipid Research, 2014
Recently it has been shown that levels of circulating oxidized LDL immune complexes (ox-LDL-ICs) predict the development of diabetic retinopathy (DR). This study aimed to investigate whether ox-LDL-ICs are actually present in the diabetic retina, and to ...
Dongxu Fu, Jeremy Y. Yu, Mingyuan Wu, Mei Du, Ying Chen, Souzan A. Abdelsamie, Yanchun Li, Junping Chen, Michael E. Boulton, Jian-xing Ma, Maria F. Lopes-Virella, Gabriel Virella, Timothy J. Lyons   +12 more
doaj   +1 more source

Differences in the metabolism of oxidatively modified low density lipoprotein and acetylated low density lipoprotein by human endothelial cells: inhibition of cholesterol esterification by oxidatively modified low density lipoprotein.

Journal of Lipid Research, 1989
The rate of degradation of oxidatively modified low density lipoprotein (Ox-LDL) by human endothelial cells was similar to that of unmodified low density lipoprotein (LDL), and was approximately 2-fold greater than the rate of degradation of acetylated ...
I Jialal, A Chait
doaj   +1 more source

Aggregation as well as chemical modification of LDL during oxidation is responsible for poor processing in macrophages.

Journal of Lipid Research, 1993
Aggregation is a characteristic of extensively oxidized (ox-) LDL. We wished to determine whether this structural change contributed even more to the documented poor degradation in macrophages of ox-LDL than the chemical changes. When protein degradation
HF Hoff, N Zyromski, D Armstrong, J O'Neil   +3 more
doaj   +1 more source