Results 1 to 10 of about 259,509 (210)

lnc-MRGPRF-6:1 Promotes ox-LDL-Induced Macrophage Ferroptosis via Suppressing GPX4. [PDF]

Mediators Inflamm, 2023
Background Ferroptosis, a newly discovered mode of cell death, emerges as a new target for atherosclerosis (AS). Long noncoding RNAs (lncRNAs) are involved in the regulation of ferroptosis.
You Z, Ye X, Jiang M, Gu N, Liang C.
europepmc   +2 more sources

Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease. [PDF]

Cardiovasc Diabetol, 2023
Objective Diabetic kidney disease (DKD) is characterized by the abnormal deposition of oxidized low-density lipoprotein (ox-LDL), which contributes to podocyte damage. Klotho, an aging suppressor that plays a critical role in protecting podocytes in DKD,
Jiang W, Gan C, Zhou X, Yang Q, Chen D, Xiao H, Dai L, Chen Y, Wang M, Yang H, Li Q.   +10 more
europepmc   +2 more sources

Myricetin ameliorates ox-LDL-induced HUVECs apoptosis and inflammation via lncRNA GAS5 upregulating the expression of miR-29a-3p

Scientific Reports, 2021
Oxidized low-density lipoprotein (ox-LDL)-induced endothelial cell dysfunction is a significant event in the progression of atherosclerosis. Even Myricetin (Myr) has been exhibited strong antioxidant potency, the effect on atherosclerosis is still ...
Yunpeng Bai, Xiankun Liu, Qingliang Chen, Tongyun Chen, Nan Jiang, Zhigang Guo   +5 more
doaj   +2 more sources

Ox-LDL induces a non-inflammatory response enriched for coronary artery disease risk in human endothelial cells [PDF]

Scientific Reports
Oxidised low-density lipoprotein cholesterol (ox-LDL) is critical in the initiation and progression of atherosclerosis. While excessive atherogenic lipids in the arterial intima can trigger endothelial dysfunction in advanced lesions, the response of ...
Jiahao Jiang, Thomas K. Hiron, Anil Chalisey, Yashaswat Malhotra, Thomas Agbaedeng, Chris A. O’Callaghan   +5 more
doaj   +3 more sources

D-limonene modulates AMPK signaling to inhibit ox-LDL-induced foam cell formation [PDF]

Scientific Reports
One of the primary mechanisms of atherosclerosis involves foam cell formation induced by oxidized low-density lipoprotein (ox-LDL). This study aims to explore the potential of D-limonene to inhibit ox-LDL-induced foam cell formation by activating the ...
Guangyu Luo, Fang Fang, Yanyan Guo, Yue Li, Xin Luo   +4 more
doaj   +2 more sources

siLOXL2 Inhibits Endothelial Inflammatory Response and EndMT Induced by ox-LDL [PDF]

Cerebrovascular Diseases Extra
Introduction: Our research aimed to investigate the potential role and mechanism of lysyl oxidase (LOX)-like 2 (LOXL2) in atherosclerosis (AS) by using the human umbilical vein endothelial cells (HUVECs) stimulated by oxidized low-density lipoprotein (ox-
Jing Ma, Jia Ling, Rui Tong, Jiefen Guo, Zhongsheng Zhu   +4 more
doaj   +2 more sources

Involvement of LDL and ox-LDL in Cancer Development and Its Therapeutical Potential

Frontiers in Oncology, 2022
Lipid metabolism disorder is related to an increased risk of tumorigenesis and is involved in the rapid growth of cancer cells as well as the formation of metastatic lesions.
Changfeng Deng, Neng Zhu, Tan-jun Zhao, Hong-fang Li, Jia Gu, D. Liao, Li Qin   +6 more
semanticscholar   +1 more source

A study to determine the prevalence of oxidised low-density lipoprotein in retinal venous occlusion in a population of West Bengal

Asian Journal of Medical Sciences, 2023
Background: Oxidized low-density lipoprotein (ox-LDL) has been implicated in both coronary artery disease and retinal vein occlusion (RVO) because of atherosclerosis. However, there is no study to show the prevalence of ox-LDL in RVO till date.
Kapil Deb Lahiri , Amit Kumar Gupta , Utpal Kumar Biswas   +2 more
doaj   +1 more source

Anti-Inflammatory Activity of Geraniol Isolated from Lemon Grass on Ox-LDL-Stimulated Endothelial Cells by Upregulation of Heme Oxygenase-1 via PI3K/Akt and Nrf-2 Signaling Pathways

Nutrients, 2022
Among the world’s leading causes of cardiovascular disease, atherosclerosis is a chronic inflammatory disorder that affects the arteries. Both vasodilation and vasoconstriction, low levels of nitric oxide and high levels of reactive oxygen species and ...
R. Ben Ammar, M. Mohamed, Manal A. Alfwuaires, Sarah Abdulaziz Alamer, Mohammad Bani ismail, V. Veeraraghavan, Ashok Kumar Sekar, R. Ksouri, Peramaiyan Rajendran   +8 more
semanticscholar   +1 more source

Reducing the Damage of Ox-LDL/LOX-1 Pathway to Vascular Endothelial Barrier Can Inhibit Atherosclerosis

Oxidative Medicine and Cellular Longevity, 2022
Aim. The destruction of the vascular endothelial barrier mediated by Ox‐LDL is the initial link to atherosclerosis. Here, we aimed to determine whether the immunological intervention with Ox‐ApoB polypeptide fragment (Ox‐ApoB‐PF) can block the deposition
Xiaopeng Guo, Yishan Guo, Zhiwen Wang, Bingxin Cao, C. Zheng, Zhuanglin Zeng, Yumiao Wei   +6 more
semanticscholar   +1 more source