Results 121 to 130 of about 10,824 (225)

Design, synthesis, enzymatic and <i>in vivo</i> antihyperglycemic activity evaluation of 1,3,4-oxadiazole derivatives targeting multiple pathways in type 2 diabetes. [PDF]

RSC Adv
Shereen, Tahir A, Ahmed A, Jan MS, Aslam N, Hassan S, Rashid U.   +6 more
europepmc   +1 more source

New 5-(pyridin-3-yl)-1,3,4-oxadiazoles derivatives as VEGFR2 inhibitors: <i>in silico</i> study, synthesis, and cytotoxicity evaluation. [PDF]

Res Pharm Sci
Abdulhussein AN, Oleiwi MA.
europepmc   +1 more source

Design, Synthesis and Biological Evaluation of Oxadiazole-Biphenyl Derivatives as Small Molecule Inhibitors Targeting PD-1/PD-L1 Immune Checkpoint. [PDF]

ACS Med Chem Lett
Xie L, Zhu M, Zhao T, Pei Y, Wei B, Zhu S, Chen J, Zhang H, Zhou J.   +8 more
europepmc   +1 more source

Experimental and MEDT Study of Sydnone-Alkyne Cycloaddition-Based Synthesis of 1,4-Disubstituted Pyrazoles and In Silico Investigation of Their Binding to HCV and HIV Proteins. [PDF]

Molecules
Zerbib S, Eddahmi M, Alaqarbeh M, Bodet PE, Thiery V, Fatimi A, Cruz-Martins N, Bailly C, Domingo LR, Bouissane L.   +9 more
europepmc   +1 more source

Recent Developments in Ferulic Acid- and Caffeic Acid-Based Hybrids with Potential Anticancer Properties. [PDF]

Molecules
Peter S, Sibali LL, Khwaza V, Paca AM.
europepmc   +1 more source

Novel pyrazole-oxadiazole-chalcone/oxime hybrids as dual EGFR/VEGFR-2 inhibitors with promising anticancer potential: a comprehensive cytotoxicity evaluation, mechanistic insights and SAR analysis. [PDF]

Mol Divers
Alshazly O, Abdel-Aziz M, Abuo-Rahma GEA, Mohamed MFA.   +3 more
europepmc   +1 more source

Design, synthesis and antiproliferative, apoptotic, and immunomodulatory properties of new heteroaryl pyridine-linked 1,2,4-oxadiazoles as prospective dual EGFR/BRAF^V600E inhibitors. [PDF]

RSC Adv
Gomaa HAM, Shaker ME, Alzarea SI, Alatwi E, Mohamed FAM, Abdullah Alzahrani AY, Alyami BA, Bräse S, Rabea SM, Youssif BGM.   +9 more
europepmc   +1 more source

Bridging mechanism and design: modern medicinal chemistry approaches to thymidylate synthase inhibitors. [PDF]

RSC Adv
Al-Karmalawy AA, Eissa ME, Yousef TA, Al Khatib AO, Hawas SS.   +4 more
europepmc   +1 more source

Lonidamine-1,3,4-oxadiazole derivatives with antiproliferative effects on HCT116 colon cancer cell lines: biological evaluation, ADMET, and computational studies. [PDF]

RSC Adv
Bhat RM, Priyadarshini AN, Sudhanva MS, Muddapur GV, Alhussieni K, K RK, Keri RS.   +6 more
europepmc   +1 more source

Design, synthesis and antiproliferative activity of oxadiazole derivatives as potent glycogen synthase kinase-3/histone deacetylase 6 dual inhibitors. [PDF]

J Enzyme Inhib Med Chem
Ye C, Chen Z, Jiang J, Li J, Kong R, Liu S, Chen X, Xu Z.   +7 more
europepmc   +1 more source