Results 111 to 120 of about 12,035 (216)

New 1,2,4-oxadiazole derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease: design, synthesis, and biological evaluation

BMC Chemistry
A series of new 1,2,4-oxadiazole-based derivatives were synthesized and evaluated for their anti-AD potential. The results revealed that eleven compounds (1b, 2a-c, 3b, 4a-c, and 5a-c) exhibited excellent inhibitory potential against AChE, with IC50 ...
Mohammed Salah Ayoup, Mariam Ghanem, Hamida Abdel-Hamid, Marwa M. Abu-Serie, Aliaa Masoud, Doaa A. Ghareeb, Mohammed B. Hawsawi, Amr Sonousi, Asmaa E. Kassab   +8 more
doaj   +1 more source

Eco-Friendly Pectin-Derived Heterocycles as Potent Larvicides: Biochemical and Insecticidal Insights Against Culex pipiens With Computational Investigation. [PDF]

Chem Biodivers
Fahim AM, Salem ME, Kamal OMHM.
europepmc   +1 more source

Iodine-mediated 2,5-di(aryl/heteroaryl)-1,3,4-oxadiazoles: synthesis, and <i>in vitro</i> and <i>in silico</i> studies of anticancer and antifungal properties. [PDF]

RSC Adv
Ramesha T, Shenoy TN, Subba Reddy UV, Ega JK, Gogula SS, Swathi B, Burgula S, Reddy PM, Abdul Salam AA.   +8 more
europepmc   +1 more source

Dual targeting of VEGFR-2 and FAK kinases by novel benzimidazole-oxadiazole hybrids: a potential approach in cancer therapy. [PDF]

RSC Adv
Abdel-Mohsen HT, Omar MA, Nageeb AM, Abdelsamie AS, El Kerdawy AM.   +4 more
europepmc   +1 more source

New 1,3-Oxazole and 1,2,4-Oxadiazole Derivatives as Novel Agents Against Human Rhinovirus and Cytomegalovirus. [PDF]

ChemMedChem
Rybina YY, Kachaeva MV, Olejniczak AB, Denel-Bobrowska M, Zhirnov VV, Semenyuta IV, Pilyo SG.   +6 more
europepmc   +1 more source

Design and synthesis of 1,3,4-oxadiazole-tethered <i>N</i>-substituted isatin hybrids as SARS-CoV-2 main protease inhibitors: biological evaluation, kinetic investigation, and <i>in silico</i> studies. [PDF]

RSC Adv
Al-Warhi T, Islam Mukim MS, Elsayed ZM, Omar YM, Elimam DM, Shaldam MA, El-Damasy AK, Elbadawi MM, Tawfik HO, Song DG, Eldehna WM.   +10 more
europepmc   +1 more source

Synthesis of novel 1,2,4-oxadiazole-isoxazoline hybrids and their in silico potential with adenosine receptors. [PDF]

Beilstein J Org Chem
Mohammed PS, Dalo MKS, Yazıcı OC, Yildirim M, Sağırlı A.   +4 more
europepmc   +1 more source

Design and computational evaluation of <i>E</i>-stilbene-bearing 1,3,4-oxadiazole derivatives as potential tyrosinase inhibitors using DFT, molecular docking and ADMET studies. [PDF]

RSC Adv
Javed A, Khan ZA, Zahoor AF.
europepmc   +1 more source

Evaluation of the in vitro activity of synthetic derivatives of N-cyclohexyl-3-(3-methylphenyl)-1,2,4-oxadiazole-5-amine on the strain y of Trypanosoma cruzi and an in vivo toxicity study. [PDF]

Mem Inst Oswaldo Cruz
Rocha YM, Ribeiro LR, de Moura GA, Chaves MM, Rodrigues JPV, Magalhães EP, Barbosa SICG, Frota LS, de Morais SM, da Silva WMB, de Oliveira VNEM, de Oliveira RN, Martins AMC, Nicolete R.   +13 more
europepmc   +1 more source

A new and efficient synthesis of substituted 2-amino-1,3,4-oxadiazoles from isothiocyanates and hydrazides. [PDF]

BMC Chem
Wu L, Tian H, Zhang Y, Ma W, Zhang Q, Chen R, Chen X.   +6 more
europepmc   +1 more source