Results 211 to 220 of about 25,633 (260)

Synthesis, In vitro α-Glucosidase Inhibitory Potential and Molecular Docking Studies of 2-Amino-1,3,4-Oxadiazole Derivatives.

Medicinal chemistry, 2020
BACKGROUND In the recent past, we had synthesized and reported different derivatives of oxadiazoles as potential α-glucosidase inhibitors. Keeping in mind, the pharmacological aspects of oxadiazole moiety and in continuation of our ongoing research on ...
H. Ullah, F. Rahim, M. Taha, Raffaqat Hussain, A. Wadood, Mohsan Nawaz, Z. Wahab, Kanwal, K. Khan   +8 more
semanticscholar   +1 more source

Oxadiazole isomers: all bioisosteres are not created equal

MedChemComm, 2012
Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.
Goldberg, Kristin, Groombridge, Sam, Hudson, Julian, Leach, Andrew G., MacFaul, Philip A., Pickup, Adrian, Poultney, Ruth, Scott, James S., Svensson, Per H., Sweeney, Joseph   +9 more
openaire   +1 more source

Synthesis of novel of 2, 5-disubstituted 1, 3, 4- oxadiazole derivatives and their in vitro anti-inflammatory, anti-oxidant evaluation, and molecular docking study.

Bioorganic & Medicinal Chemistry Letters, 2020
A series of novel 2, 5-disubstituted 1, 3, 4-Oxadiazole derivatives as a potential anti-inflammatory, and anti-oxidant agent were synthesized via cyclisation.
B. Kashid, P. H. Salunkhe, B. B. Dongare, Kishor R. More, V. Khedkar, A. Ghanwat   +5 more
semanticscholar   +1 more source

The new era of 1,2,4-oxadiazoles

Organic & Biomolecular Chemistry, 2009
The synthesis, the chemical and photochemical reactivity, and the use of 1,2,4-oxadiazoles in materials and as bioactive compounds have been reviewed. The material in this survey includes some historical background, general features, state-of-the-art applications together with a critical discussion about current limitations and suggestions for future ...
PACE, Andrea, PIERRO, Paola
openaire   +3 more sources

Oxadiazole-Triphenylamine derivatives for OLEDs

SPIE Proceedings, 2005
Electroluminescent bipolar small molecules have been attracted with great interests recently. They are found to exhibit many interesting features such as (i) reducing the structural complexity of organic light emitting diodes (OLEDs) from multilayer heterojunction to monolayer homojunction devices; (ii) offering molecular p/n junction, and (iii ...
Leung, LM, Menglian, G, Xiang, NJ, Choy, WCH, Hui, KN, Liang, YJ, Tong, KL, So, SK   +7 more
openaire   +2 more sources

Banana-shaped 1,2,4-oxadiazoles

Pramana, 2003
3,5-Disubstituted 1,2,4-oxadiazoles are a new type of liquid crystalline (LC) compounds with asymmetrical five-membered heterocycle as a central unit. They have a bent shape and are very convenient model-compounds for studying the dependence of the LC properties on the molecular design.
S. I. TORGOVA, T. A. GEIVANDOVA, O. FRANCESCANGELI, STRIGAZZI, Alfredo   +3 more
openaire   +2 more sources

1,2,3‐Oxadiazoles

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +1 more source

A Preferred Synthesis of 1,2,4‐Oxadiazoles

Synthetic Communications, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Brenda Pipik, Guo‐Jie Ho, J. Michael Williams, David A. Conlon   +3 more
openaire   +1 more source

Oxadiazoles

2011
Abdul Rauf, Nida Nayyar Farshori
  +6 more sources

Oxadiazole grafts in peptide macrocycles

Nature Chemistry, 2016
Synthetic methods that provide control over macrocycle conformation and, at the same time, mitigate the polarity of peptide bonds represent valuable tools for the discovery of new bioactive molecules. Here, we report a macrocyclization reaction between a linear peptide, an aldehyde and (N-isocyanimino)triphenylphosphorane.
John R, Frost, Conor C G, Scully, Andrei K, Yudin   +2 more
openaire   +2 more sources