Results 191 to 200 of about 25,633 (260)

1,3,4‐oxadiazole and its derivatives: A review on recent progress in anticancer activities

Chemical Biology and Drug Design, 2020
The 1,3,4‐oxadiazole nucleus is a biologically imperative scaffold possesses numerous biological activities. The broad and potent activity of 1,3,4‐oxadiazole and their derivatives has established them as important pharmacological scaffolds especially in
Ankur Vaidya, D. Pathak, K. Shah
semanticscholar   +1 more source

A patent review of pharmaceutical and therapeutic applications of oxadiazole derivatives for the treatment of chronic diseases (2013–2021)

Expert Opinion on Therapeutic Patents, 2022
Introduction Oxadiazole is a unique class of heterocycle, possessing numerous important biomedical and therapeutic applications, such as anti-bacterial, anti-cancer, anti-inflammatory, inhibitors for diverse enzymes, receptor modulators, and ...
Abbas Hassan, Abid Hussain Khan, F. Saleem, H. Ahmad, K. Khan   +4 more
semanticscholar   +1 more source

Banana-Shaped 1,2,4-Oxadiazole Analogues of 1,3,4-Oxadiazoles

Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals, 2001
Abstract In the last years bent banana-shaped mesomorphic molecules found an increasingly great interest among theoreticians and experimentalists due to the nature of this type of liquid crystals to exhibit a spontaneous polarization in the absence of any chiral group in the molecules.
S. I. TORGOVA, L. A. KARAMYSHEVA, T. A. GEIVANDOVA, STRIGAZZI, Alfredo   +3 more
openaire   +2 more sources

Experimental characterization, machine learning analysis and computational modelling of the high effective inhibition of copper corrosion by 5‐(4‐pyridyl)‐1,3,4‐oxadiazole‐2‐thiol in saline environment

Electrochimica Acta, 2021
An oxadiazole derivative with functional groups favouring its adsorption on copper surface, namely 5-(4-pyridyl)-1,3,4-oxadiazole-2-thiol, has been explored as potential inhibitor of copper corrosion in 3.5 wt.% NaCl.
S. Varvara, C. Berghian-Groșan, R. Bostan, R. L. Ciceo, Zohreh Salarvand, M. Talebian, K. Raeissi, J. Izquierdo, Ricardo M. Souto   +8 more
semanticscholar   +1 more source

Perfluoro-1,3,4-oxadiazoles

Journal of Fluorine Chemistry, 1992
Abstract Some new polyfluorinated 1,3,4-oxadiazoles have been obtained via a two-step method. The cycloadditions of the 1,3,4-oxadiazoles have been studied and an analysis of the energies of the frontier orbitals calculated by the MNDO method indicates a LUMO-dependent pathway for cycloaddition.
N.V. Vasiliev, Yu.E. Lyashenko, A.E. Patalakha, G.A. Sokolski   +3 more
openaire   +1 more source

Oxadiazoles in Medicinal Chemistry

Journal of Medicinal Chemistry, 2012
Oxadiazoles are five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom, and they exist in different regioisomeric forms. Oxadiazoles are frequently occurring motifs in druglike molecules, and they are often used with the intention of being bioisosteric replacements for ester and amide functionalities.
Jonas, Boström, Anders, Hogner, Antonio, Llinàs, Eric, Wellner, Alleyn T, Plowright   +4 more
openaire   +2 more sources

1,2,4‐Oxadiazoles

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +1 more source

1,2,5-Oxadiazoles

ChemInform, 1996
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +1 more source

Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole

Molecules, 2018
Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. Their anti-proliferative effects associated with various mechanisms, such as inhibition of growth factors, enzymes, kinases and ...
TERESA Glomb, Piotr Swiatek, Swiatek Piotr   +2 more
exaly   +2 more sources

Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy.

European journal of medicinal chemistry, 2021
Harnessing the antioxidant cellular machinery has sparked considerable interest as an efficient anticancer strategy. Activating Nrf2, the master switch of the cellular redox system, suppresses ROS, alleviates oxidative stress, and halts cancer ...
M. Ayoup, Marwa M. Abu‐Serie, H. Abdel‐Hamid, M. Teleb   +3 more
semanticscholar   +1 more source