Results 201 to 210 of about 25,633 (260)

Design, synthesis, modelling studies and biological evaluation of 1,3,4-oxadiazole derivatives as potent anticancer agents targeting thymidine phosphorylase enzyme.

Bioorganic chemistry (Print), 2021
A series of novel 1,3,4-oxadiazole derivatives with substituted phenyl ring were designed and synthesized with an objective of discovering newer anti-cancer agents targeting thymidine phosphorylase enzyme (TP).
S. Bajaj, Maushmi S. Kumar, Hussain Tinwala, Mayur Yc   +3 more
semanticscholar   +1 more source

Poly‐1,3,4‐oxadiazoles. I. Polyphenylene‐1,3,4‐oxadiazoles

Journal of Polymer Science Part A: General Papers, 1965
AbstractPolyphenylene‐1,3,4‐oxadiazoles have been prepared from benzenedicarboxylic acids or their derivatives and hydrazine by solution polycondensation in fuming sulfuric acid or polyphosphoric acid. These polymers were characterized by good thermal stability, and the molecular weights attained were high enough for the products to exhibit fiber‐or ...
Yoshio Iwakura, Keikichi Uno, Shigeyoshi Hara   +2 more
openaire   +1 more source

Synthesis of alkynylated 1,2,4-oxadiazole/1,2,3-1H-triazole glycoconjugates: Discovering new compounds for use in chemotherapy against lung carcinoma and Mycobacterium tuberculosis.

European journal of medicinal chemistry, 2021
A total of forty-three compounds were synthesized, including thirty-two new ones. Among those compounds, seventeen were selected and tested on human tumor cell lines: PC-3 (prostate adenocarcinoma), HCT-116 (colorectal tumor), NCIH-460 (lung carcinoma ...
Valentina Nascimento e Melo de Oliveira, Cybele Flávia do Amaral Moura, A. Peixoto, Vanessa Gonçalves Ferreira, H. M. Araújo, Lílian Maria Lapa Montenegro Pimentel, C. Pessoa, R. Nicolete, Janaina Versiani dos Anjos,, P. Sharma, B. Rathi, L. Pena, P. Rollin, A. Tatibouët, Ronaldo Nascimento de Oliveira   +14 more
semanticscholar   +1 more source

Anti-tuberculosis activity and its structure-activity relationship (SAR) studies of oxadiazole derivatives: A key review.

European journal of medicinal chemistry, 2020
With the increasing number of cases of inactive and drug-resistance tuberculosis, there is an urgent need to develop new potent molecules set for fighting this brutal disease.
S. Verma, R. Verma, S. Verma, Y. Vaishnav, S. Tiwari, K. Rakesh   +5 more
semanticscholar   +1 more source

Infrared spectra of 1,3,4-oxadiazole and 2,5,-dimethyl-1,3,4-oxadiazole. Vibrational assignment of 1,3,4-oxadiazole

Journal of Molecular Spectroscopy, 1967
Abstract The infrared absorption spectrum of 1,3,4-oxadiazole has been recorded in the region 5000-400 cm −1 in the vapor and in the liquid phases, in CS 2 and C 2 Cl 4 solutions. Also, the infrared absorption spectrum of liquid 2,5-dimethyl-1,3,4-oxadiazole was recorded in the same region. A tentative assignment of the fundamental vibrations of 1,
Daniel Højgaard Christensen, Jørgen Tormod Nielsen, Ole Faurskov Nielsen   +2 more
openaire   +1 more source

1,3,4-Oxadiazole Bridges: A Strategy to Improve Energetics at the Molecular Level.

Angewandte Chemie, 2020
Many energetic materials synthesized to date have limited applications because of low thermal and/or mechanical stability. This limitation can be overcome by introducing structural modifications such as a bridging group.
Jinchao Ma, A. Chinnam, G. Cheng, Hongwei Yang, Jiaheng Zhang, J. Shreeve   +5 more
semanticscholar   +1 more source

Synthesis, in vitro antibacterial and antifungal evaluation of novel 1,3,4-oxadiazole thioether derivatives bearing the 6-fluoroquinazolinylpiperidinyl moiety

Chinese Chemical Letters, 2020
A series of structurally novel 1,3,4-oxadiazole thioether derivatives ( 6a ― 6z ) containing a 6-fluoroquinazolinylpiperidinyl moiety were designed and synthesized using pharmacophore hybrid approach, and their structures were fully characterized by 1 H ...
Jun Shi, Na Luo, Muhan Ding, Xiaoping Bao   +3 more
semanticscholar   +1 more source

Design, synthesis, biological evaluation and molecular docking of new uracil analogs-1,2,4-oxadiazole hybrids as potential anticancer agents.

Bioorganic & Medicinal Chemistry Letters, 2020
A new series of uracil analogues-1,2,4-oxadiazole hybrid derivatives were synthesized by a new, simple, and efficient method using for the first time HAP-SO3H as an heterogenous acid catalyst for the condensation and cyclization between amidoxime and ...
Az-eddine El Mansouri, Ali Oubella, M. Maatallah, Moulay Youssef Aititto, M. Zahouily, H. Morjani, H. Lazrek   +6 more
semanticscholar   +1 more source

Design and synthesis of novel 1,3,4-oxadiazole sulfone compounds containing 3,4-dichloroisothiazolylamide moiety and evaluation of rice bacterial activity.

Pesticide Biochemistry and Physiology, 2020
In this study, thirty 1,3,4-oxadiazole sulfone derivatives containing 3,4-dichloroisothiazolamide moiety were designed and synthesized, and their antibacterial activities were evaluated.
Jie Xiang, Dengyue Liu, Jixiang Chen, D. Hu, B. Song   +4 more
semanticscholar   +1 more source

1,2,4-Oxadiazole topsentin analogs as staphylococcal biofilm inhibitors targeting the bacterial transpeptidase sortase A.

European journal of medicinal chemistry, 2020
The inhibition or prevention of biofilm formation represents an emerging strategy in the war against antibiotic resistance, interfering with key players in bacterial virulence.
B. Parrino, D. Carbone, S. Cascioferro, Camilla Pecoraro, E. Giovannetti, D. Deng, Veronica Di Sarno, Simona Musella, G. Auriemma, M. Cusimano, D. Schillaci, G. Cirrincione, P. Diana   +12 more
semanticscholar   +1 more source