Results 181 to 190 of about 25,633 (260)

Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism.

Journal of Medicinal Chemistry, 2023
Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family mainly targeting cytosolic nonhistone substrates, such as α-tubulin, cortactin, and heat shock protein 90 to regulate cell proliferation, metastasis, invasion, and mitosis in tumors.
L. Ripa, Jenny Sandmark, Glyn Hughes, Igor Shamovsky, Anders Gunnarsson, Julia Johansson, A. Llinàs, Mia Collins, Bomi Jung, Anna Novén, Nils Pemberton, M. Mogemark, Yao Xiong, Qing Li, Stefan Tångefjord, M. Ek, Annika Åstrand   +16 more
semanticscholar   +1 more source

A key review on oxadiazole analogs as potential methicillin-resistant Staphylococcus aureus (MRSA) activity: Structure-activity relationship studies.

European journal of medicinal chemistry, 2021
Methicillin-resistant Staphylococcus aureus (MRSA) is becoming dangerous to human beings due to easy transmission mode and leading to the difficult-to-treat situation.
S. Verma, R. Verma, K. S. S. Kumar, L. Banjare, A. Shaik, Richie R. Bhandare, K. P. Rakesh, K. Rangappa   +7 more
semanticscholar   +1 more source

Unique Carbazole-Oxadiazole Derivatives as New Potential Antibiotics for Combating Gram-Positive and -Negative Bacteria.

Journal of Medicinal Chemistry, 2022
Novel carbazole-oxadiazoles were developed as new potential antibacterial agents to combat dreadful resistance. Some target compounds displayed predominant inhibitory effects on the tested Gram-positive and -negative bacteria, and carbazole-oxadiazoles ...
Yun-Peng Xie, Nagarajan Sangaraiah, J. Meng, Cheng‐He Zhou   +3 more
semanticscholar   +1 more source

A first-principles evaluation on the interaction of 1,3,4-oxadiazole with pristine and B-, Al-, Ga-doped C60 fullerenes

Journal of Molecular Liquids, 2021
In this study, the interaction of 1,3,4-oxadiazole with pristine and B-, Al-, Ga-doped C60 fullerenes were examined by density functional theory (DFT) for the first time.
İskender Muz, Mustafa Kurban
exaly   +2 more sources

Antibacterial and Antiviral Activities of 1,3,4-Oxadiazole Thioether 4H-Chromen-4-one Derivatives.

Journal of Agricultural and Food Chemistry, 2021
Various 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives were conceived. The title compounds demonstrated striking inhibitory effects against Xac, Psa, and Xoo. EC50 data exhibited that A8 (19.7 μg/mL) had better antibacterial activity against Xoo
Feng Peng, Tin-yin Liu, Qifan Wang, Fang Liu, Xiao Cao, Jinsong Yang, Li-wei Liu, C. Xie, Wei Xue   +8 more
semanticscholar   +1 more source

Synthesis and antimicrobial activity of some 1,3,4-oxadiazole derivatives

Il Farmaco, 2002
Six new 5-(1-/2-naphthyloxymethyl)-1,3,4-oxadiazole-2(3H)-thione, 2-amino-5-(1-/2-naphthyloxymethyl)-1,3,4-oxadiazole, 5-(1-/ 2-naphthyloxymethyl)-1,3,4-oxadiazole-2(3H)-one derivatives have been synthesized from 1-and/or 2-naphthol.
Erhan Palaska, Melike Ekizoğlu, Meral Özalp   +2 more
exaly   +2 more sources

Review of the biological activities of heterocyclic compounds comprising oxadiazole moieties.

Current Topics in Medicinal Chemistry, 2022
The oxadiazole core is considered as a privileged moiety in many medicinal chemistry applications. The oxadiazole class includes 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,3,4-oxadiazole and 1,2,5-oxadiazole.
B. Ruan, Qinglei Guo, Qingshan Li, Lulin Li, G. S. Deora, Ben-Guo Zhou   +5 more
semanticscholar   +1 more source

Enhancement of Energetic Performance through the Construction of Trinitromethyl Substituted β-Bis(1,2,4-oxadiazole).

Journal of Physical Chemistry Letters, 2022
Halogen-free substitutions of ammonium perchlorate (AP), which meet the requirements of high density, high performance, and acceptable stability, have been a subject of scientific research for many years.
Jinya Zhang, Jinxiong Cai, Nihan Chen, Teng Fei, Chunlin He, S. Pang   +5 more
semanticscholar   +1 more source

Insights into the inhibition mechanism of 2,5-bis(4-pyridyl)-1,3,4-oxadiazole for carbon steel corrosion in hydrochloric acid pickling via experimental and computational approaches

Journal of Molecular Liquids, 2021
The addition of 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (4-POX) as organic corrosion inhibitor of carbon steel (CS) in 1 M HCl solution was assessed exploiting weight loss and electrochemical measurements as well as surface analyses.
I. Nadi, M. Bouanis, F. Benhiba, K. Nohair, A. Nyassi, A. Zarrouk, C. Jama, F. Bentiss   +7 more
semanticscholar   +1 more source

1,3,4‐oxadiazole derivatives as potential antimicrobial agents

Chemical Biology and Drug Design, 2022
Due to the emergence of drug‐resistant microbial strains, different research groups are continuously developing novel drug molecules against already exploited and unexploited targets.
D. Tiwari, R. Narang, Kalvatala Sudhakar, Vikramjeet Singh, S. Lal, M. Devgun   +5 more
semanticscholar   +1 more source