Results 171 to 180 of about 10,824 (225)

Oxadiazoles in Medicinal Chemistry

Journal of Medicinal Chemistry, 2012
Oxadiazoles are five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom, and they exist in different regioisomeric forms. Oxadiazoles are frequently occurring motifs in druglike molecules, and they are often used with the intention of being bioisosteric replacements for ester and amide functionalities.
Jonas, Boström, Anders, Hogner, Antonio, Llinàs, Eric, Wellner, Alleyn T, Plowright   +4 more
openaire   +2 more sources

Poly‐1,3,4‐oxadiazoles. I. Polyphenylene‐1,3,4‐oxadiazoles

Journal of Polymer Science Part A: General Papers, 1965
AbstractPolyphenylene‐1,3,4‐oxadiazoles have been prepared from benzenedicarboxylic acids or their derivatives and hydrazine by solution polycondensation in fuming sulfuric acid or polyphosphoric acid. These polymers were characterized by good thermal stability, and the molecular weights attained were high enough for the products to exhibit fiber‐or ...
Yoshio Iwakura, Keikichi Uno, Shigeyoshi Hara   +2 more
openaire   +1 more source

1,2,4‐Oxadiazoles

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +1 more source

Infrared spectra of 1,3,4-oxadiazole and 2,5,-dimethyl-1,3,4-oxadiazole. Vibrational assignment of 1,3,4-oxadiazole

Journal of Molecular Spectroscopy, 1967
Abstract The infrared absorption spectrum of 1,3,4-oxadiazole has been recorded in the region 5000-400 cm −1 in the vapor and in the liquid phases, in CS 2 and C 2 Cl 4 solutions. Also, the infrared absorption spectrum of liquid 2,5-dimethyl-1,3,4-oxadiazole was recorded in the same region. A tentative assignment of the fundamental vibrations of 1,
Daniel Højgaard Christensen, Jørgen Tormod Nielsen, Ole Faurskov Nielsen   +2 more
openaire   +1 more source

1,2,5-Oxadiazoles

ChemInform, 1996
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +1 more source

Bioisosterism: 1,2,4‐Oxadiazole Rings

ChemMedChem, 2023
AbstractAlthough studies in drug discovery have gained momentum in recent years, the conversion of drugs in use today into less toxic derivatives with pharmacologically superior properties is still of great importance in drug research. Bioisosterism facilitates the conversion of drugs into derivatives that present more positive pharmacological and ...
Merve Camci, Nilgün Karali
openaire   +2 more sources

Oxadiazole isomers: all bioisosteres are not created equal

MedChemComm, 2012
Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.
Goldberg, Kristin, Groombridge, Sam, Hudson, Julian, Leach, Andrew G., MacFaul, Philip A., Pickup, Adrian, Poultney, Ruth, Scott, James S., Svensson, Per H., Sweeney, Joseph   +9 more
openaire   +1 more source

The new era of 1,2,4-oxadiazoles

Organic & Biomolecular Chemistry, 2009
The synthesis, the chemical and photochemical reactivity, and the use of 1,2,4-oxadiazoles in materials and as bioactive compounds have been reviewed. The material in this survey includes some historical background, general features, state-of-the-art applications together with a critical discussion about current limitations and suggestions for future ...
PACE, Andrea, PIERRO, Paola
openaire   +3 more sources

Oxadiazole-Triphenylamine derivatives for OLEDs

SPIE Proceedings, 2005
Electroluminescent bipolar small molecules have been attracted with great interests recently. They are found to exhibit many interesting features such as (i) reducing the structural complexity of organic light emitting diodes (OLEDs) from multilayer heterojunction to monolayer homojunction devices; (ii) offering molecular p/n junction, and (iii ...
Leung, LM, Menglian, G, Xiang, NJ, Choy, WCH, Hui, KN, Liang, YJ, Tong, KL, So, SK   +7 more
openaire   +2 more sources

Banana-shaped 1,2,4-oxadiazoles

Pramana, 2003
3,5-Disubstituted 1,2,4-oxadiazoles are a new type of liquid crystalline (LC) compounds with asymmetrical five-membered heterocycle as a central unit. They have a bent shape and are very convenient model-compounds for studying the dependence of the LC properties on the molecular design.
S. I. TORGOVA, T. A. GEIVANDOVA, O. FRANCESCANGELI, STRIGAZZI, Alfredo   +3 more
openaire   +2 more sources