Results 91 to 100 of about 32,424 (300)

2-Methylsulfanylbenzo[f]isoquinoline [PDF]

, 2015
S-Methylation of a 4-(naphth-2-yl)-β-thiolactam gives an intermediate 4-(naphth-2-yl) substituted 1-azetine which undergoes a [2+2] ring-opening followed by electrocyclic ring closure of the resulting 2-azadiene to give a benzo[f ...
Hemming, Karl, Jamshaid, Faisal, Khan, Musharraf   +2 more
core   +2 more sources

Synthesis and evaluation of some new 1,3,4-oxadiazoles bearing thiophene, thiazole, coumarin, pyridine and pyridazine derivatives as antiviral agents

Acta Pharmaceutica, 2019
In an attempt to produce heterocyclic compounds based on 1,3,4-oxadiazole derivatives with potential antiviral activity, synthesis of compound 1 [2-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)acetonitrile] was performed through the reaction of cyanoacetic
M. Albratty, K. El-Sharkawy, H. Alhazmi
semanticscholar   +1 more source

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, Volume 21, Issue 1, January 2026.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

3-Glucosylated 5-amino-1,2,4-oxadiazoles: synthesis and evaluation as glycogen phosphorylase inhibitors

Beilstein Journal of Organic Chemistry, 2015
Glycogen phosporylase (GP) is a promising target for the control of glycaemia. The design of inhibitors binding at the catalytic site has been accomplished through various families of glucose-based derivatives such as oxadiazoles.
Marion Donnier-Maréchal, David Goyard, Vincent Folliard, Tibor Docsa, Pal Gergely, Jean-Pierre Praly, Sébastien Vidal   +6 more
doaj   +1 more source

A Hybrid Photo/Biocatalytic System for the Sustainable Synthesis of L‐Alanine From Urea and Pyruvate

ChemSusChem, Volume 19, Issue 2, January 2026.
We present a visible‐light driven photo‐biocatalytic system combining urease (URE), L‐alanine dehydrogenase (AlDH) and visible‐light driven nicotinamide adenine dinucleotide (NADH) regeneration system consisting of triethanolamine (TEOA), zinc meso‐tetra(4‐sulfonatophenyl)porphyrin tetrasodium salt (ZnTPPS4‐) and [Cp*Rh(bpy)(H2O)]2+.
Kyosuke Yamada, Yutaka Amao
wiley   +1 more source

Koordinationschemie Perhalogenierter Cyclopentadine und Alkine, XV [PDF]

, 1993
Coordination Chemistry of Perhalogenated Cyclopentadienes and Alkynes, XV[1]. - Systematic Generation of Fivefold Ring-Silylated Cyclopentadienyl Manganese Complexes from [C5Br5]Mn(CO)3.
Blake, Edelman, Engelhard, Herrmann, Jutzi, Jutzi, Jutzi, Okuda, Sekiguchi, Sünkel, Sünkel, Sünkel, Winter   +12 more
core   +1 more source

Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry

ChemistryOpen, Volume 15, Issue 1, January 2026.
Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten, Raushan Koizhaiganova, Dilnaz Bissenbay, Bagila Tursynova, Zhanar Zhaxibayeva, Valentina Yu   +5 more
wiley   +1 more source

Synthetic strategies for 5- and 6-membered ring azaheterocycles facilitated by iminyl radicals [PDF]

, 2016
The author thanks EaStCHEM for financial support.The totality of chemical space is so immense that only a small fraction can ever be explored. Computational searching has indicated that bioactivity is associated with a comparatively small number of ring ...
Walton, John Christopher
core   +2 more sources

Copper(I)-Catalyzed 1,3-Dipolar Cycloaddition of Ketonitrones to Dialkylcyanamides: A Step toward Sustainable Generation of 2,3-Dihydro-1,2,4-oxadiazoles

ACS Omega, 2017
CuI-catalyzed cycloaddition (CA) of the ketonitrones, Ph2C=N+(R′)O– (R′ = Me, CH2Ph), to the disubstituted cyanamides, NCNR2 (R = Me2, Et2, (CH2)4, (CH2)5, (CH2)4O, C9H10, (CH2Ph)2, Ph(Me)), gives the corresponding 5-amino-substituted 2,3-dihydro-1,2,4 ...
Anna A. Melekhova, A. Smirnov, A. Novikov, T. Panikorovskii, N. Bokach, V. Kukushkin   +5 more
semanticscholar   +1 more source

A New Class of Benzo[b]Thiophene‐1,3,4‐Oxadizole Bearing 1,2,4‐Oxadiazoles as Potent Antimicrobial Targets: Synthesis, Biological Evaluation, Docking, DFT and ADMET Studies

ChemistrySelect, Volume 11, Issue 3, 22 January 2026.
Benzo[b]thiophene‐1,3,4‐oxadizole and 1,2,4‐oxadiazole hybrids 9a–9l were tested against both antibacterial and anticancer, revealing interesting structure‐activity relationships. density functional theory calculations (DFTs) at the B3LYP/6–311++G (d,p).
Ravikumar Gupta Miriyala, Janardan Sannapaneni, Phani Raja Kanuparthy, Venkata Ramana Singamaneni, Tejeswara Rao Allaka, Pilli Veera Venkata Nanda Kishore   +5 more
wiley   +1 more source