Results 271 to 280 of about 30,682 (325)

Oxadiazole grafts in peptide macrocycles

Nature Chemistry, 2016
Synthetic methods that provide control over macrocycle conformation and, at the same time, mitigate the polarity of peptide bonds represent valuable tools for the discovery of new bioactive molecules. Here, we report a macrocyclization reaction between a linear peptide, an aldehyde and (N-isocyanimino)triphenylphosphorane.
Conor C. G. Scully, John R. Frost, Andrei K. Yudin   +2 more
openaire   +3 more sources

Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.

Journal of Medicinal Chemistry, 2017
Sirt2 is a target for the treatment of neurological, metabolic, and age-related diseases including cancer. Here we report a series of Sirt2 inhibitors based on the 1,2,4-oxadiazole scaffold.
S. Moniot, Mariantonietta Forgione, Alessia Lucidi, G. Hailu, A. Nebbioso, V. Carafa, F. Baratta, L. Altucci, Nicola Giacchè, D. Passeri, R. Pellicciari, A. Mai, C. Steegborn, D. Rotili   +13 more
semanticscholar   +1 more source

SACCHARIDE 1,3,4-OXADIAZOLES

Organic Preparations and Procedures International, 1976
AbstractBei einer Behandlung mit Jod und HgO werden die Acylhydrazone (I) zu den entsprechenden Saccharid‐oxadiazolen (III) cyclisiert.
M. Nassr, M. Shaban
openaire   +2 more sources

A Preferred Synthesis of 1,2,4‐Oxadiazoles

Synthetic Communications, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Guo-Jie Ho, David A. Conlon, Brenda Pipik, J. Michael Williams   +3 more
openaire   +3 more sources

1,3,4‐Oxadiazoles

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +2 more sources

Banana-shaped 1,2,4-oxadiazoles

Pramana, 2003
3,5-Disubstituted 1,2,4-oxadiazoles are a new type of liquid crystalline (LC) compounds with asymmetrical five-membered heterocycle as a central unit. They have a bent shape and are very convenient model-compounds for studying the dependence of the LC properties on the molecular design.
S. I. TORGOVA, T. A. GEIVANDOVA, O. FRANCESCANGELI, STRIGAZZI, Alfredo   +3 more
openaire   +3 more sources

Water-Assisted Nitrile Oxide Cycloadditions: Synthesis of Isoxazoles and Stereoselective Syntheses of Isoxazolines and 1,2,4-Oxadiazoles.

Angewandte Chemie, 2016
Conventional methods generate nitrile oxides from oxime halides in organic solvents under basic conditions. However, the present work revealed that water-assisted generation of nitrile oxides proceeds under mild acidic conditions (pH 4-5). Cycloadditions
Chatchai Kesornpun, T. Aree, C. Mahidol, S. Ruchirawat, P. Kittakoop   +4 more
semanticscholar   +1 more source

1,3,4-Oxadiazoles as luminescent materials for organic light emitting diodes via cross-coupling reactions

, 2016
Highly efficient materials for the fabrication of OLEDs have been extensively investigated in terms of properties and convenient synthetic procedures. 2,5-Diaryl-1,3,4-oxadiazoles were found to display suitable structural features in order to act as good
A. Păun, N. Hădade, C. Paraschivescu, M. Matache   +3 more
semanticscholar   +1 more source

Iodine-Mediated Domino Oxidative Cyclization: One-Pot Synthesis of 1,3,4-Oxadiazoles via Oxidative Cleavage of C(sp(2))-H or C(sp)-H Bond.

Journal of Organic Chemistry, 2016
An I2-promoted, metal-free domino protocol for one-pot synthesis of 1,3,4-oxadiazoles has been developed via oxidative cleavage of C(sp(2))-H or C(sp)-H bonds, followed by cyclization and deacylation. In this reaction, the use of K2CO3 as a base is found
Yuxing Fan, Yongqin He, Xingxing Liu, Ting Hu, Haojie Ma, Xiaodong Yang, Xinliang Luo, Guosheng Huang   +7 more
semanticscholar   +1 more source

Synthesis, Characterization, and Properties of Di‐ and Trinitromethyl‐1,2,4‐Oxadiazoles and Salts

, 2018
The syntheses of 3-trinitromethyl-(1,2,4-oxadiazol-5-one), its N-methyl derivative, and 5-methyl-3-trinitromethyl-1,2,4-oxadiazole are described. The synthetic strategy initially involved a ring-closing step to afford the oxadiazole acetic acid ethyl ...
Tobias S. Hermann, T. Klapötke, B. Krumm, Jörg Stierstorfer   +3 more
semanticscholar   +1 more source