Results 71 to 80 of about 32,424 (300)

5-Aryl-1,3,4-oxadiazol-2-amines Decorated with Long Alkyl and Their Analogues: Synthesis, Acetyl- and Butyrylcholinesterase Inhibition and Docking Study

Pharmaceuticals, 2022
2,5-Disubstituted 1,3,4-oxadiazoles are privileged versatile scaffolds in medicinal chemistry that have exhibited diverse biological activities. Acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors are used, e.g., to treat dementias and myasthenia ...
Václav Pflégr, Šárka Štěpánková, Katarína Svrčková, Markéta Švarcová, Jarmila Vinšová, Martin Krátký   +5 more
doaj   +1 more source

Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles

RSC Advances, 2019
A novel methodology for general and chemoselective preparation of non-symmetric 1,3,4-oxadiazoles is developed. This unusual reaction proceeds via polyphosphoric acid-assisted activation of nitroalkanes towards nucleophilic attack with acylhydrazides.
Alexander V Aksenov, V. Khamraev, N. Aksenov, N. K. Kirilov, D. A. Domenyuk, V. Zelensky, M. Rubin   +6 more
semanticscholar   +1 more source

Investigation of the printability of ethyl 2‐[4‐(1,3,4‐oxadiazol‐2(3H)‐thion‐5‐yl)phenylhydrazono]‐3‐oxobutyrate on coated and uncoated papers

Coloration Technology, Volume 142, Issue 1, Page 67-74, February 2026.
Abstract There is a growing demand in the printing industry for pigment‐based inks with excellent lightfastness and rub resistance qualities. In this work, a novel ink with the formulation ethyl 2‐[4‐(1,3,4‐oxadiazole‐2(3H)‐thione‐5‐yl)phenylhydrazono]‐3‐oxobutyrate (OXKT) was prepared as a pigment and its printability was investigated for use in ...
Ahmet Akgül, Ş. Güniz Küçükgüzel, Mehmet Oktav, Sevim Rollas   +3 more
wiley   +1 more source

PREPARAÇÃO DE 1,2,4-OXADIAZOL: SEQUÊNCIA DIDÁTICA APLICADA EM DISCIPLINA DE SÍNTESE ORGÂNICA NA GRADUAÇÃO

Química Nova
1,2,4-oxadiazoles are used in a wide range of applications, including medicinal chemistry and chemistry of materials. However, this kind of oxadiazoles is not usually prepared in an undergraduate organic teaching laboratory.
Juliana L. L. Freire Regueira, Jucleiton J. R. de Freitas, João R. de Freitas Filho   +2 more
doaj   +1 more source

Boulton-Katritzky Rearrangement of 5-Substituted Phenyl-3-[2-(morpholin-1-yl)ethyl]-1,2,4-oxadiazoles as a Synthetic Path to Spiropyrazoline Benzoates and Chloride with Antitubercular Properties

Molecules, 2021
The analysis of stability of biologically active compounds requires an accurate determination of their structure. We have found that 5-aryl-3-(2-aminoethyl)-1,2,4-oxadiazoles are generally unstable in the presence of acids and bases and are rearranged ...
Lyudmila Kayukova, Anna Vologzhanina, Kaldybai Praliyev, Gulnur Dyusembaeva, Gulnur Baitursynova, Asem Uzakova, Venera Bismilda, Lyailya Chingissova, Kydyrmolla Akatan   +8 more
doaj   +1 more source

Preparation of perfluorinated 1,2,4-oxadiazoles [PDF]

, 1982
Fluorinated alkyl or alkylether 1,2,4 oxadiazole compounds are prepared by cyclizing the corresponding alkyl or alkylether imidoyl amidoximes in vacuo or in an inert atmosphere at a temperature within the range of 40 C to 100 C.
Ito, T. I., Kratzer, R. H., Paciorek, K. J. L., Rosser, R. W.   +3 more
core   +1 more source

QSAR-Driven Discovery of Novel Chemical Scaffolds Active against Schistosoma mansoni. [PDF]

, 2016
Schistosomiasis is a neglected tropical disease that affects millions of people worldwide. Thioredoxin glutathione reductase of Schistosoma mansoni (SmTGR) is a validated drug target that plays a crucial role in the redox homeostasis of the parasite.
Anne E. Carpenter, Bruno J. Neves, Carolina H. Andrade, Cleber C. Melo-Filho, Eugene N. Muratov, Floriano P. Silva-Junior, João M. Rezende-Neto, Kroemer R. T., Lee Kamentsky, Lowis D. R., Mario R. Senger, Nicholas Furnham, Rafael F. Dantas, Rodolpho C. Braga, Ross A. Paveley, Walter C. G. Valente, Willian T. Chaves   +16 more
core   +3 more sources

Synthesis of 1,2,4-Oxadiazoles by Tandem Reaction of Nitroalkenes with Arenes and Nitriles in the Superacid TfOH.

Journal of Organic Chemistry, 2019
The tandem reaction of nitroalkenes with arenes and nitriles in the superacid CF3SO3H (TfOH) results in the formation of 1,2,4-oxadiazole derivatives in yields up to 96%.
Andrei A Golushko, O. Khoroshilova, A. Vasilyev   +2 more
semanticscholar   +1 more source

Ringed spherulitic and undulated textures in the nematic phase of a mixture of trans-4-hexylcyclohexanecarboxylic and benzoic acids

, 2009
We present a polarising optical microscopy study of a liquid-crystal mixture of trans-4-hexylcyclohexanecarboxylic acid (C6) and benzoic acid. Both materials have carboxylic groups that can form dimers through hydrogen bonding. The mixture is nematic and
Sparavigna, Amelia Carolina
core   +1 more source

The dissociation of the Hsp60/pro-Caspase-3 complex by bis(pyridyl)oxadiazole copper complex (CubipyOXA) leads to cell death in NCI-H292 cancer cells [PDF]

, 2017
Cell survival and proliferation are central to carcinogenesis, involving various mechanisms among which those that impede apoptosis are important. In this, the role of the molecular chaperone Hsp60 is unclear since it has been reported that it can be ...
Barone, G., Barone, R., Campanella, C., Cappello, F., Caruso Bavisotto, C., Conway de Macario, E., Giacalone, V., Lo Cascio, F., Macario, A., Marino Gammazza, A., Mocciaro, E., Nikolic, D., Pace, A., Palumbo Piccionello, A., Zummo, G.   +14 more
core   +1 more source