Results 81 to 90 of about 30,682 (325)

Ammonium formate-Pd/C as a new reducing system for 1,2,4-oxadiazoles. Synthesis of guanidine derivatives and reductive rearrangement to quinazolin-4-ones with potential anti-diabetic activity [PDF]

, 2021
1,2,4-Oxadiazole is a heterocycle with wide reactivity and many useful applications. The reactive O-N bond is usually reduced using molecular hydrogen to obtain amidine derivatives.
Buscemi S., Marzullo P., Nuzzo D., Pace A., Palumbo Piccionello A., Vasto S.   +5 more
core   +1 more source

β‐Lactam Ylidenes: An Overlooked Class of N‐Heterocyclic Carbenes

Chemistry – A European Journal, EarlyView.
A highly modular synthetic approach toward four‐membered β‐lactam carbenes (BLCs) is presented. BLCs feature moderate σ‐donor and strong π‐acceptor character, leading to a pronounced ambiphilic reactivity which includes the formation of olefinic dimers as well as unprecedented N2‐bridged dimers, oxirane formation with acetone, and fragmentation to ...
Leonard Karl, Daniel Deißenbeck, Jan Meisner, Christian Ganter   +3 more
wiley   +1 more source

Synthesis of 2-Isobutyl, 2-Isobutyl-5-aryl and 2-Isobutyl-5-thiol-1,3,4-Oxadiazoles [PDF]

مجلة التربية والعلم, 2007
In this paper the synthesis of some substituted 1,3,4-oxadiazoles from isobutyric acid was studied. The isobutyric acid was converted into the corresponding ethyl ester, which then treated with hydrazine hydrate in ethanol to give the acid hydrazide. The
Hadil S. Aziz, Khalid M. Daoud
doaj   +1 more source

Boulton-Katritzky Rearrangement of 5-Substituted Phenyl-3-[2-(morpholin-1-yl)ethyl]-1,2,4-oxadiazoles as a Synthetic Path to Spiropyrazoline Benzoates and Chloride with Antitubercular Properties

Molecules, 2021
The analysis of stability of biologically active compounds requires an accurate determination of their structure. We have found that 5-aryl-3-(2-aminoethyl)-1,2,4-oxadiazoles are generally unstable in the presence of acids and bases and are rearranged ...
Lyudmila Kayukova, Anna Vologzhanina, Kaldybai Praliyev, Gulnur Dyusembaeva, Gulnur Baitursynova, Asem Uzakova, Venera Bismilda, Lyailya Chingissova, Kydyrmolla Akatan   +8 more
doaj   +1 more source

Síntese, atividade antimicrobiana e estudo in silico de 1,2,4-oxadiazóis derivados do levulinato de etila [PDF]

, 2020
This study describes the synthesis, antimicrobial activity, and in silico assessment of 1,2,4-oxadiazoles from ethyl levulinate. For that, we prepared arylamidoximes and treated them with ethyl levulinate, obtaining the respective 1,2,4-oxadiazoles ...
Alves Caina, Rodrigo Ribeiro, Bezerra, Gisele Barbosa, da Cunha Lima, Josefa Aqueline, de Freitas Filho, João Rufino, Rufino Freitas, Juliano Carlo, Santos Costa, Erick Caique, Silva, Jadson de Farias   +6 more
core   +2 more sources

Synthesis and evaluation of some new 1,3,4-oxadiazoles bearing thiophene, thiazole, coumarin, pyridine and pyridazine derivatives as antiviral agents

Acta Pharmaceutica, 2019
In an attempt to produce heterocyclic compounds based on 1,3,4-oxadiazole derivatives with potential antiviral activity, synthesis of compound 1 [2-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)acetonitrile] was performed through the reaction of cyanoacetic
M. Albratty, K. El-Sharkawy, H. Alhazmi
semanticscholar   +1 more source

Synthesis, Antimycobacterial Activity and Computational Insight of novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates Against Multidrug‐Resistant M. tuberculosis

ChemMedChem, Accepted Article.
To search for new antitubercular agents, we have designed, synthesized, and evaluated a series of 1,4‐benzoxazinone‐based compounds. These molecules showed potent antimycobacterial activity, with MIC between 2 and 8 μg/mL. This interesting profile included activity against several drug‐resistant strains and minimal cytotoxicity against mammalian Vero ...
Daniele Zampieri, Maria Grazia Mamolo, Emanuele Carosati, Diletta Pasin, Alessandro De Logu, Gianluigi Cabiddu, Marko Jukic   +6 more
wiley   +1 more source

Preparation of perfluorinated 1,2,4-oxadiazoles [PDF]

, 1982
Fluorinated alkyl or alkylether 1,2,4 oxadiazole compounds are prepared by cyclizing the corresponding alkyl or alkylether imidoyl amidoximes in vacuo or in an inert atmosphere at a temperature within the range of 40 C to 100 C.
Ito, T. I., Kratzer, R. H., Paciorek, K. J. L., Rosser, R. W.   +3 more
core   +1 more source

Ringed spherulitic and undulated textures in the nematic phase of a mixture of trans-4-hexylcyclohexanecarboxylic and benzoic acids

, 2009
We present a polarising optical microscopy study of a liquid-crystal mixture of trans-4-hexylcyclohexanecarboxylic acid (C6) and benzoic acid. Both materials have carboxylic groups that can form dimers through hydrogen bonding. The mixture is nematic and
Sparavigna, Amelia Carolina
core   +1 more source

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

ChemMedChem, EarlyView.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina Aït Amiri, Valérie Lefort, Anthony Nina‐Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source