Results 161 to 170 of about 133,537 (299)

Antiviral regulator TRIM25 as a prognostic marker of better survival in Merkel cell carcinoma: Association with MCPyV status

International Journal of Cancer, EarlyView.
What's New? TRIM25 is known for its role in antiviral immunity and association with poor prognosis in various cancers. This study reveals an association between high TRIM25 expression and Merkel cell polyomavirus positivity in Merkel cell carcinoma.
Klaus W. Fagerstedt, Sami Kilpinen, Johanna Arola, Benjamin Z. Sundqvist, Tom Böhling, Leif C. Andersson, Harri Sihto   +6 more
wiley   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Development of a prognostic model for chemotherapy response and identification of TNFAIP2 as a target in colorectal cancer

Scientific Reports
Oxaliplatin, a key chemotherapeutic agent, often induces resistance in colorectal cancer (CRC) treatment, highlighting the urgent need for reliable biomarkers to predict treatment efficacy.
Cheng Zhou, Chuan-Hai Xu, Min Xu, Xin-Kun Huang, Bin Zhu   +4 more
doaj   +1 more source

A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer.

Journal of Clinical Oncology, 2004
R. Goldberg, D. Sargent, R. Morton, C. Fuchs, R. Ramanathan, S. Williamson, B. Findlay, H. Pitot, S. Alberts   +8 more
semanticscholar   +1 more source

A Genome‐Wide Association Study of Colorectal Cancer Mortality Outcomes Among Individuals of African and Admixture Ancestry

Molecular Carcinogenesis, EarlyView.
ABSTRACT African Americans have the highest colorectal cancer (CRC) mortality rates in the United States. We performed the first genome‐wide association study (GWAS) of overall and CRC‐specific mortality among African Americans with incident CRC to identify genetic contributors to CRC outcomes.
Thomas Lawler, Jirong Long, Rene Welch, Irene Ong, Oluwatoyosi Ogunmuyiwa, Rida A. Khatri, Martha Shrubsole, Shaneda Warren Andersen   +7 more
wiley   +1 more source

Nano Delivery Strategy Opens Effective Avenues for the Treatment of Colorectal Cancer

Medicine Bulletin, EarlyView.
ABSTRACT Colorectal cancer (CRC) presents significant therapeutic challenges because of chemoresistance, systemic toxicity, and the complexity of the tumor microenvironment (TME). Nanodrug delivery systems (NDDS) have emerged as versatile platforms capable of overcoming these limitations by enhancing tumor accumulation, improving pharmacokinetics, and ...
Qiurong Wei, Yunli Xu, Tianjiao Zhang, Shuyu Xu, Haonan Wang, Yuan Wang, Xinxin Xie, Xiaolong Liang   +7 more
wiley   +1 more source

Addressing the distressing: Pancreatic enzyme replacement therapy mitigates abdominal symptoms and weight loss during chemotherapy for advanced pancreatic cancer: A prospective study

Nutrition in Clinical Practice, EarlyView.
Abstract Background Pancreatic enzyme insufficiency (PEI) contributes to symptom burden and malnutrition in advanced pancreatic cancer (aPC). We aimed to evaluate the impact of pancreatic enzyme replacement therapy (PERT) on symptom burden and weight during chemotherapy.
Pamela N. Klassen, Christina A. Kim, Jessica Kasnik, Michael B. Sawyer, Sunita Ghosh, Vickie Baracos, Vera C. Mazurak   +6 more
wiley   +1 more source

Biomarker‐based long‐term safety and efficacy of PD‐1/PD‐L1 inhibitors combined with chemotherapy in advanced gastroesophageal carcinomas: A systematic review and meta‐analysis

Precision Medical Sciences, EarlyView.
This graphical abstract concisely encapsulates the principal findings of the meta‐analysis, emphasizing the notable survival advantages of PD‐1/PD‐L1 inhibitors in conjunction with chemotherapy for advanced gastroesophageal tumors. The visual presentation briefly defines the study's history, methodologies, results, and conclusions, while highlighting ...
Muhammad Ahsan, Muhammad Javaid Umer, Rath Shree, Jan Qureshi Ahmar, Ahmad Khan Mudassir, Masood Salman, Muhammad Hassan, Hayyat Omna, Iqbal Javed, Asraf Hussain   +9 more
wiley   +1 more source

Nanoparticle polymeric micellar paclitaxel compared with paclitaxel for advanced esophageal squamous cell carcinoma

Precision Medical Sciences, EarlyView.
The nanoparticle polymeric micellar paclitaxel plus nedaplatin regimen demonstrates superior efficacy and tolerable toxicities compared to the paclitaxel–nedaplatin combination as a first‐line treatment for advanced esophageal squamous cell carcinoma.
Yu‐Qing Cao, Meng Song, Bing‐jie Xue, Fei‐Yu Wang, Xiang‐Ming Huang, Jie Cao, Ai‐Guo Cao, Xin‐En Huang   +7 more
wiley   +1 more source

Development and validation of a multimodal model based on histopathological and computed tomography imaging for predicting survival outcomes in stage III colorectal cancer

VIEW, EarlyView.
Patients with stage III colorectal cancer exhibit substantial heterogeneity in clinical outcomes despite receiving standardized treatments, which complicates accurate risk stratification. In this study, we integrated features derived from routine histopathological slides and preoperative computed tomography scans using machine learning to develop a ...
Danyi Li, Zhangxin Zhao, Genxia Wei, Weihao Qiu, Zhihao Lin, Jiankun He, Bingbing Li, Jing Wang, Lisheng Zheng, Feiyan Feng, Xiangkun Wu, Zhengyu Zhang, Jinbang Li, Mingxing Qiu, Shujing Guo, Chenglong Zhao, Ying Tan, Yueping Liu, Qingling Zhang, Yu Zhang, Li Liang   +20 more
wiley   +1 more source