Results 21 to 30 of about 104,817 (211)

KIAA1199 promotes oxaliplatin resistance and epithelial mesenchymal transition of colorectal cancer via protein O-GlcNAcylation

Translational Oncology, 2023
Oxaliplatin is a commonly used platinum drug for colorectal cancer (CRC). However, the treatment of CRC by oxaliplatin usually fails because of drug resistance, which results in a huge challenge in the therapy of CRC.
Qingling Hua, Yuanyuan Lu, Dingxiang Wang, Jie Da, Wanren Peng, Guoping Sun, Kangsheng Gu, Hua Wang, Yanzhe Zhu   +8 more
doaj   +1 more source

Anti epidermal growth factor receptor therapy in small bowel adenocarcinoma [PDF]

, 2018
Rationale:Small bowel adenocarcinoma (SBA) is an uncommon gastrointestinal cancer, thus limited data about treatment for advanced disease are available.
Anselmi, Elisabetta, Falcone, Rosa, Filetti, Marco, Marchetti, Paolo, Roberto, Michela   +4 more
core   +1 more source

Goshajinkigan, a Traditional Japanese Medicine, Prevents Oxaliplatin-Induced Acute Peripheral Neuropathy by Suppressing Functional Alteration of TRP Channels in Rat

Journal of Pharmacological Sciences, 2014
.: The acute peripheral neuropathy induced by oxaliplatin treatment occurs very frequently and is aggravated by exposure to cold. Goshajinkigan (GJG), a traditional Japanese (kampo) medicine, was recently shown to be effective against oxaliplatin-induced
Keita Mizuno, Toru Kono, Yasuyuki Suzuki, Chika Miyagi, Yuji Omiya, Kanako Miyano, Yoshio Kase, Yasuhito Uezono   +7 more
doaj   +1 more source

Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy [PDF]

, 2013
Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer ...
Chan, Kiat-Hwa, Gopalan, Began, Hauser, Charlotte A. E., Joshi, Mangesh, Lakshmanan, Anupama, Lam, Dang Hoang, Mishra, Archana, Reithofer, Michael R., Wang, Shu   +8 more
core   +1 more source

Impact of the Specific Mutation in KRAS Codon 12 Mutated Tumors on Treatment Efficacy in Patients with Metastatic Colorectal Cancer Receiving Cetuximab-Based First-Line Therapy: A Pooled Analysis of Three Trials [PDF]

, 2012
Purpose: This study investigated the impact of specific mutations in codon 12 of the Kirsten-ras (KRAS) gene on treatment efficacy in patients with metastatic colorectal cancer (mCRC).
Allegra CJ, Amado RG, Andreas Jung, Andreyev HJ, Bazan V, Bokemeyer C, Bos JL, Boughdady IS, Cappuzzo F, Cerottini JP, Christoph C. Zielinski, De Roock W, Dominik P. Modest, Douillard JY, Finkelstein SD, Frattini M, Galina Kurteva, Heinemann V, Janja Ocvirk, Jens Neumann, Jonker DJ, Karapetis CS, Khambata-Ford S, Khosravi-Far R, Lièvre A, Maughan TS, Moosmann N, Neumann J, Ocvirk J, Regina Knittelfelder, Roth AD, Ruediger P. Laubender, Samowitz WS, Scheffzek K, Sebastian Stintzing, Thomas Brodowicz, Thomas Kirchner, Tournigand C, Tveit K, Van Cutsem E, Volker Heinemann, Zsuzsanna Papai   +41 more
core   +1 more source

A phase II study of capecitabine and oxalplatin combination chemotherapy in patients with inoperable adenocarcinoma of the gall bladder or biliary tract [PDF]

, 2016
Background: Advanced biliary tract carcinomas are associated with a poor prognosis, and palliative chemotherapy has only modest benefit. This multi-centre phase II study was conducted to determine the efficacy of capecitabine in combination with ...
E. Soulis, F. Y. Coxon, J. S. Graham, K. Boyd, L. R. Wall, M. Highley, M. M. Eatock, P. Bützberger-Zimmerli, S. Harden, T. R. J. Evans, T. S. Maughan   +10 more
core   +1 more source

Contribution of Piezo2 to endothelium-dependent pain. [PDF]

, 2015
BackgroundWe evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Bogen, Oliver, Ferrari, Luiz F, Green, Paul, Levine, Jon D   +3 more
core   +2 more sources

Advances in the Management of Oxaliplatin-Induced Neuropathy: Focus on Glutamine and Using Pharmacogenomics to Predict the Effectiveness of Opioid Drugs

Journal of Cancer Research and Practice, 2014
One form of neurotoxicity is the principal and dose-limiting toxicity of oxaliplatin. It has been observed that the incidence of oxaliplatin-induced severe neurotoxicity has varied from 12% to 18% in different clinical trials.
Wei-Shu Wang
doaj   +1 more source

Factors influencing choice of chemotherapy in metastatic colorectal cancer (mCRC) [PDF]

, 2013
Management of metastatic colorectal cancer requires a multimodal approach and must be performed by an experienced, multidisciplinary expert team. The optimal choice of the individual treatment modality, according to disease localization and extent, tumor
BASSO, ENRICO, CARUSO, DAVIDE, EVANGELISTA, SALVATORE, Foteini Vakiarou, G. Rinaldi, L. Bianchi, Lo Russo, Giuseppe, PAPA, ANSELMO, Perrone-congedi, Francesca, PRETE, ALESSANDRA ANNA, ROSSI, Luigi, SPINELLI, GIAN PAOLO, Stati, Valeria, TOMAO, SILVERIO, VERRICO, MONICA, ZORATTO, federica   +15 more
core   +1 more source

Oxaliplatin administration increases expression of the voltage-dependent calcium channel α2δ-1 subunit in the rat spinal cord

Journal of Pharmacological Sciences, 2016
Oxaliplatin is a chemotherapeutic agent that is effective against various types of cancer including colorectal cancer. Acute cold hyperalgesia is a serious side effect of oxaliplatin treatment.
Ken Yamamoto, Mayuko Tsuboi, Toshie Kambe, Kenji Abe, Yoshihiko Nakatani, Kazuyoshi Kawakami, Iku Utsunomiya, Kyoji Taguchi   +7 more
doaj   +1 more source