Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.Hypoxia, oncogenic signaling, transcriptional and epigenetic remodeling, and H. pylori–microbiota interactions drive the Warburg effect in gastric cancer. Enhanced glycolysis and lactate export support biosynthesis, remodel the tumor microenvironment, promote stromal activation and immune suppression, and reveal actionable biomarkers and therapeutic ...
Guanmo Liu +7 more
wiley +1 more source
Applications of Bioinorganic Nano‐Based Delivery Systems—Diagnostics and Therapeutics
Drug Development Research, Volume 87, Issue 5, August 2026.ABSTRACT Nanotechnology has emerged as a promising avenue for producing nanomedicines as alternatives to conventional drugs. Many organic nanoparticles, such as liposomes used in formulations like Doxil, Onivyde, and Marqibo, are approved by the Food and Drug Administration (FDA) and instrumental in treating various types of cancers.
Frank Ssengooba +2 more
wiley +1 more source
KLF5 promotes tumor proliferation and oxaliplatin resistance via chromatin remodeling in KRAS-mutated colorectal cancer. [PDF]
Cancer Drug ResistXu Z, Sun S, Gao H, Feng R, Shen X.
europepmc +1 more source
Epilepsia Open, Volume 11, Issue 4, Page 1095-1110, August 2026.Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini +9 more
wiley +1 more source
Targeting the <i>ZMYM2-ANXA9</i> Axis: Organoid Models Illuminate a Novel Pathway to Overcome Oxaliplatin Resistance in Colorectal Cancer. [PDF]
BiomedicinesZeng SJ, He K, Shi Z.
europepmc +1 more source
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background and Aims Circulating tumor DNA (ctDNA) has emerged as a promising biomarker of tumor burden and minimal residual disease. As total neoadjuvant therapy (TNT) increasingly supports organ‐preserving strategies in locally advanced rectal cancer (LARC), reliable markers of treatment response are needed.
Faizan Bashir +4 more
wiley +1 more source
Multi-omics analysis of patient-derived organoids reveals that E3 ligase COP1 promotes liver metastasis and oxaliplatin resistance in colorectal cancer through LUZP1 degradation and MYL9 phosphorylation. [PDF]
Exp Hematol OncolZhang R +15 more
europepmc +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao +4 more
wiley +1 more source
Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat. [PDF]
Oncol RepRöttgen H +8 more
europepmc +1 more source
The Dual Role of the Gut Microbiota in Cancer Chemoresistance
MicrobiologyOpen, Volume 15, Issue 4, August 2026.Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi +3 more
wiley +1 more source