Results 171 to 180 of about 2,234,624 (258)

Hypoxia-induced lnc-IRP drives oxaliplatin resistance in colorectal cancer through IRP2 sequestration and iron metabolism reprogramming. [PDF]

J Transl Med
Yang H, Wang X, Li S, Zhang M, Zhou Z, Yang J, Zhang X, Gao M, Zhang H.   +8 more
europepmc   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

Ferroptosis-based therapeutic strategy targeting iron metabolism and SLC7A11 overcomes oxaliplatin resistance in patient-derived pancreatic cancer organoids. [PDF]

J Exp Clin Cancer Res
Choi JH, Lee KM, Oh M, Noh J, Kim Y, Hwang E, Cho IR, Paik WH, Ryu JK, Ku JL, Lee SH.   +10 more
europepmc   +1 more source

Beyond the Monolayer: Leveraging 3D Culture Systems to Decode Mechanisms of Drug Resistance and Therapeutic Vulnerabilities in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Two‐dimensional (2D) monolayer cultures remain the workhorse of colorectal cancer (CRC) research and high‐throughput screening (HTS), yet they poorly recapitulate tissue architecture, extracellular matrix (ECM) cues, metabolic gradients, and multicellular heterogeneity that govern drug response in vivo. Over the past decade, three‐dimensional (
Sarah J. Harmych, Bhuminder Singh
wiley   +1 more source

CUL4B promotes hepatocellular carcinoma progression and oxaliplatin resistance by facilitating FUS degradation. [PDF]

Cell Death Dis
Wei JD, Cheng K, Wu X, Zhang L, Wang Q, Liang Y, Zhu Z, Meng W, Chen W, Guan X, Yang H, Zhou L.   +11 more
europepmc   +1 more source

Basal Marker ΔNp63α Is Enriched in Pancreatic Cancer Metastases but Not in Primary Tumors Post‐Chemotherapy

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Cancer cells within a single pancreatic ductal adenocarcinoma (PDAC) are most often heterogeneous in their expression of the basal or classical transcriptional program. Predominance of the basal subtype has been associated with poorer patient outcomes and increased resistance to chemotherapy.
Daniel H. Ryan, Yuuki Ohara, Michael J. Kruhlak, Xianyu Zhang, Miao Lin, Chin‐Hsien Tai, Christine Alewine   +6 more
wiley   +1 more source

Exosomal lncRNA NORAD drives oxaliplatin resistance in AEG via the miR-433-3p/autophagy axis: a novel mechanism and potential biomarker. [PDF]

Cancer Cell Int
Ma H, Wang J, Liu J, Li H, Zhang X, Chen Y, Gong Y, Hu R, Zhang Y, Qiu X, Li S.   +10 more
europepmc   +1 more source

Real‐World Overall Survival With Abiraterone Acetate and Enzalutamide in Patients With Chemotherapy‐Naïve Metastatic Castration‐Resistant Prostate Cancer From the Flatiron Electronic Health Records Database

Cancer Medicine, Volume 15, Issue 10, October 2026.
This real‐world study of the Flatiron Health database found that first‐line treatment with abiraterone versus enzalutamide was associated with significantly shorter overall survival, treatment duration, and time to subsequent treatment in patients with chemotherapy‐ and androgen receptor pathway inhibitor‐naïve metastatic castration‐resistant prostate ...
Daniel J. George, Jasmina I. Ivanova, Maëlys Touya, Betty Thompson, Jonathan Assayag, Benjamin Li, Nikolaos Kountouris, Gordon Siu, Stephen J. Freedland   +8 more
wiley   +1 more source

Endothelin-1 Mediates Oxaliplatin Resistance via Activation of YAP Signaling in Colorectal Cancer. [PDF]

Oncol Res
Yang R, Yuan D, Liang C, Zhu S, Huang J, Zhang Y, He W, Li Q, Zhang H.   +8 more
europepmc   +1 more source

Gene expression profiling of oxaliplatin-resistant cell lines [PDF]

Nature Genetics, 2001
Goli Samimi, Jim Breaux, Misako Mishima, Charles Berry, Stephen Howell, Gerrit Los   +5 more
openaire   +1 more source