Results 191 to 200 of about 47,533 (300)

Author response for "iRGD‐modified exosomes effectively deliver CPT1A siRNA to colon cancer cells, reversing oxaliplatin resistance by regulating fatty acid oxidation"

, 2021
Dan Lin, Haiyang Zhang, Rui Liu, Ting Deng, Tao Ning, Ming Bai, Yuchong Yang, Kegan Zhu, Junyi Wang, Jingjing Duan, Shaohua Ge, Bei Sun, Guoguang Ying, Yi Ba   +13 more
openalex   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, Volume 13, Issue 28, 18 May 2026.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization

, 2021
Joshua D. Greenlee, Maria Lopez‐Cavestany, Nerymar Ortiz-Otero, Kevin Liu, Tejas Subramanian, Burt Cagir, Michael R. King   +6 more
openalex   +1 more source

Tanshinone IIA reverses oxaliplatin resistance in colorectal cancer through microRNA-30b-5p/AVEN axis [PDF]

, 2022
Tingrui Ge, Yonggang Zhang
openalex   +1 more source

Mature Tertiary Lymphoid Structures Indicate Good Chemotherapy Response and Prognosis in Advanced Colorectal Cancer

Annals of Gastroenterological Surgery, Volume 10, Issue 3, Page 710-721, May 2026.
In advanced colorectal cancer, tumors with mature tertiary lymphoid structures (TLS) exhibited abundant infiltration of CD3‐ and CD8‐positive lymphocytes in both primary and metastatic sites, indicating an activated immune response. The presence of mature TLS was also associated with favorable chemotherapy sensitivity and improved prognosis.
Nobuhiro Hosoi, Chika Komine, Gendensuren Dorjkhorloo, Takuya Shiraishi, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Takehiko Yokobori, Ken Shirabe, Hiroshi Saeki   +9 more
wiley   +1 more source

miR-188 promotes Oxaliplatin resistances through targeting RASA1 in colon cancer cells [PDF]

, 2020
Xijia Zhu, Xishun Luo, Zhike Song, Shiyu Jiang, Xiangkai Long, Xuanyuan Gao, Xinyang Xie, Laijian Zheng, Haipeng Wang   +8 more
openalex   +1 more source

Impact of Body Weight Loss During Preoperative Chemoradiotherapy on Prognosis of Patients With Lower Rectal Cancer

Annals of Gastroenterological Surgery, Volume 10, Issue 3, Page 722-738, May 2026.
The present study aimed to investigate the relationship between changes in body weight and composition during chemoradiotherapy, such as the psoas muscle mass index, visceral fat index, and subcutaneous fat index obtained from computed tomography images, and long‐term outcomes in rectal cancer patients.
Shinya Abe, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Yuzo Nagai, Yuzo Harada, Takahide Shinagawa, Soichiro Ishihara   +9 more
wiley   +1 more source

Targeting the NSUN2-DHODH axis reverses ferroptosis resistance and oxaliplatin resistance in colorectal cancer. [PDF]

Front Pharmacol
Zhang J, Shen J, Zeng T, Gao C, Sheng B, Li J, Zeng W, Shen J, Shen C, Wang J, Wang J.   +10 more
europepmc   +1 more source

Simultaneous Establishment of Autologous Colorectal Cancer and Mesothelial Stromal Cell Lines from Malignant Ascites Reveals a Mesothelial‐Stromal FGFR3 Axis as a Potential Vulnerability in Peritoneal Metastasis

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Colorectal cancer (CRC) with peritoneal dissemination remains a major therapeutic challenge because of poor prognosis and limited treatment options. Experimental models that accurately recapitulate tumor–mesothelial interactions are scarce. Here, we report the establishment of a novel autologous paired model comprising a CRC cell line (OMUCR‐1)
Yasuhiro Fukui, Hiroaki Kasashima, Zizhou Wang, Iguru Omori, Yukina Kusunoki, Kanae Echizen, Yoshiki Nonaka, Yuki Seki, Kenji Kuroda, Yuichiro Miki, Mami Yoshii, Tatsunari Fukuoka, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Yu Muta, Yuki Nakanishi, Masakazu Yashiro, Naoko Ohtani, Kiyoshi Maeda   +19 more
wiley   +1 more source

CUL4B promotes hepatocellular carcinoma progression and oxaliplatin resistance by facilitating FUS degradation. [PDF]

Cell Death Dis
Wei JD, Cheng K, Wu X, Zhang L, Wang Q, Liang Y, Zhu Z, Meng W, Chen W, Guan X, Yang H, Zhou L.   +11 more
europepmc   +1 more source