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Establishment of oxaliplatin-resistant gastric cancer organoids: importance of myoferlin in the acquisition of oxaliplatin resistance [PDF]
, 2023 内容の要約
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Role of Dicer in regulating oxaliplatin resistance of colon cancer cells
Biochemical and Biophysical Research Communications, 2018Colorectal cancer (CRC) is a major health problem due to its high mortality rate. The incidence of CRC is increasing in young individuals. Oxaliplatin (OXA) is an approved third-generation drug and is used for first-line chemotherapy in CRC. Although current standard chemotherapy improves the overall survival of CRC patients, an increasing number of ...
Hui-Huang Lai +3 more
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Altered glutathione metabolism in oxaliplatin resistant ovarian carcinoma cells
Cancer Letters, 1996Elevation of glutathione (GSH) is commonly observed in cellular resistance to a number of anticancer agents. Most frequently reported change in GSH metabolism that is associated with the elevated GSH levels is increased mRNA expression and activity of gamma-glutamyl cysteine synthetase (gamma GCS), the first enzyme of the GSH biosynthetic pathway.
Z, el-akawi +6 more
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Cellular Resistance to Oxaliplatin and Drug Accumulation Defects
2009Platinum drugs are employed in a wide range of solid tumors, and represent the mainstay of the first-line therapy of ovarian carcinoma. Although cisplatin has shown efficacy in the treatment of different types of tumors including ovarian carcinoma, resistance to treatment is a major limitation.
Laura Gatti, Paola Perego
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TGFB1-mediated autophagy facilitates oxaliplatin resistance in stomach adenocarcinoma
Biochemistry and Cell BiologyIncreasing evidence has indicated that transforming growth factor beta 1 (TGFB1) is engaged in tumorigenesis and progression. Nevertheless, the underlying role and mechanism of TGFB1 in stomach adenocarcinoma (STAD) chemotherapy remains unknown. TGFB1 levels in various types of cancers were first analyzed by the TCGA database.
Qihua Xu +7 more
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Exosomal miR-208b related with oxaliplatin resistance promotes Treg expansion in colorectal cancer
Molecular Therapy, 2021Yi Ba, Guoguang Ying, Hai-Yang Zhang
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Oxaliplatin and its derivatives – An overview
Coordination Chemistry Reviews, 2023Darren M Griffith +2 more
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ΔNp73 overexpression induces oxaliplatin-resistance in colon cancer
2017Peer ...
Bonilla, Félix, Domínguez, Gemma
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