Results 211 to 220 of about 47,533 (300)

Potential Biological Targets of Anticancer Metal‐Based Drug Candidates: A Systematic Review

Drug Development Research, Volume 87, Issue 3, May 2026.
ABSTRACT The discovery of Cisplatin marked the beginning of the metallodrug era in oncology. Despite their clinical success, platinum‐based compounds present important limitations, including drug resistance and systemic toxicity. These challenges have stimulated interest in alternative metal complexes capable of interacting with biomolecular targets ...
Allysson L. dos S. Ferreira, Bruna B. Dantas, Jailton De Souza‐Ferrari, Edilson B. Alencar Filho   +3 more
wiley   +1 more source

Proximity Labelling Reveals the Compartmental Proteome of Murine Sensory Neurons

European Journal of Pain, Volume 30, Issue 5, May 2026.
ABSTRACT Introduction Understanding the molecular architecture of peripheral sensory neurons is critical as we pursue novel drug targets against pain and neuropathy. Sensory neurons in the dorsal root ganglion (DRG) show extensive compartmentalization; thus, understanding each compartment—from the peripheral to central terminals—is key to this effort ...
Julia R. Sondermann, Allison M. Barry, Feng Xian, Thomas Haberl, David Gomez‐Varela, Fritz Benseler, Dietmar Schreiner, Nils Brose, Noa Lipstein, Manuela Schmidt   +9 more
wiley   +1 more source

Hederagenin Promotes Sorafenib Sensitivity in Hepatocellular Carcinoma Through Suppressing SLC7A11 Expression and Inducing Ferroptosis

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
This study combining network pharmacology with molecular docking further confirmed via in vitro experiments that HED potentiates the anti‐tumor effect of sorafenib in HCC cells through the downregulation of SLC7A11 expression and the induction of ferroptosis.
Hai‐mei Jiang, Yu‐wan Zhou, Jian‐yu Zhang, Fu‐zhen Pan, Jin‐Fang Zhang, Ya‐ge Zhang   +5 more
wiley   +1 more source

In silico assessment of coriander leaf extract active compound to resensitize oxaliplatin resistance in colorectal cancer mediated by ABCG2 and UPF1 proteins

Sun JESSICA, Sandra B. FILEMON, Sharron SANTOSA, Stephani C. MAHARANI, Arli Aditya Parikesit   +4 more
openalex   +2 more sources

Probiotics Cancer Interaction, Prevention, and Therapy

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Cancer is a significant global health concern and ranks as the second most common cause of death on a worldwide scale. A combination of hereditary and lifestyle variables, such as diet, smoking, alcohol consumption, physical exercise, and the gut microbiota, impacts cancer development. Dysbiosis, an imbalance in gut microorganisms, can promote
Mostafa Saebi, Amir Hossein Barjasteh, Mahmoud Mahmoudi, Ramiar Kamal Kheder, Setayesh Ramazanpour, Negar Ebadpour, Afsane Fadaee, Seyed‐Alireza Esmaeili   +7 more
wiley   +1 more source

Zebularine Boosts Imatinib Efficacy in Cells of Colorectal Cancer via Wnt‐Survivin‐P‐Glycoprotein Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.
The combination of IM and ZEB showed a promising combination in management of CRC by inducing oxidative stress, promoting apoptosis, and modulating critical genes involved in metastasis and apoptosis. ABSTRACT Colorectal cancer (CRC) remains one of the leading causes of cancer mortality, with a poor survival rate of less than 15%.
Yasmin M. Attia, Abeer Elkhoely, Fatma M. Abdelwahed, Samia A. Shouman, Mervat M. Omran   +4 more
wiley   +1 more source

ΔNp73 overexpression induces oxaliplatin-resistance in colon cancer

, 2015
Peer ...
Bonilla, Félix, Domínguez, Gemma
openaire   +1 more source

Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 5, May 2026.
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang, Zengkan Du, Ping Lu, Aimin Jiang, Yadong Guo, Yawei Liu, Zhijing Song, Bing Dai, Wangzheqi Zhang   +8 more
wiley   +1 more source

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source

KLF5 promotes tumor proliferation and oxaliplatin resistance via chromatin remodeling in KRAS-mutated colorectal cancer. [PDF]

Cancer Drug Resist
Xu Z, Sun S, Gao H, Feng R, Shen X.
europepmc   +1 more source