Results 221 to 230 of about 47,533 (300)

The identification of CRNDE, H19, UCA1 and HOTAIR as the key lncRNAs involved in oxaliplatin or irinotecan resistance in the chemotherapy of colorectal cancer based on integrative bioinformatics analysis

, 2019
Fangfang Sun, Weiwei Liang, Jing Qian
openalex   +2 more sources

Gene expression profiling of oxaliplatin-resistant cell lines [PDF]

Nature Genetics, 2001
Goli Samimi, Jim Breaux, Misako Mishima, Charles Berry, Stephen Howell, Gerrit Los   +5 more
openaire   +1 more source

Deep learning‐based H&E‐derived risk scores in colorectal cancer: associations with tumour morphology, biology, and predicted drug response

The Journal of Pathology, Volume 269, Issue 1, Page 112-124, May 2026.
Abstract Over recent years, several deep learning (DL) models have been presented to predict colorectal cancer (CRC) patient survival directly from haematoxylin and eosin (H&E)‐stained routine whole‐slide images (WSIs). Unlike traditional studies that rely on manually defined histopathological features, weakly supervised DL allows training directly on ...
Nic G Reitsam, Xiaofeng Jiang, Junhao Liang, Bianca Grosser, Veselin Grozdanov, Chiara ML Loeffler, Marco Gustav, Tim Lenz, Hannah S Muti, Zunamys I Carrero, Nicholas P West, Philip Quirke, Sebastian Foersch, Moritz Jesinghaus, Wolfram Müller, Tanwei Yuan, Michael Hoffmeister, Hermann Brenner, Jitendra Jonnagaddala, Nicholas J Hawkins, Robyn L Ward, Heike I Grabsch, Bruno Märkl, Jakob N Kather   +23 more
wiley   +1 more source

Targeting the <i>ZMYM2-ANXA9</i> Axis: Organoid Models Illuminate a Novel Pathway to Overcome Oxaliplatin Resistance in Colorectal Cancer. [PDF]

Biomedicines
Zeng SJ, He K, Shi Z.
europepmc   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, Volume 183, Issue 9, Page 1727-1746, May 2026.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Multi-omics analysis of patient-derived organoids reveals that E3 ligase COP1 promotes liver metastasis and oxaliplatin resistance in colorectal cancer through LUZP1 degradation and MYL9 phosphorylation. [PDF]

Exp Hematol Oncol
Zhang R, Luo W, Zhou Q, Liang D, Hao Y, Chen F, Qiu Y, Cao Y, Shan Z, Zhang Y, Li Q, Cai S, Luo D, Mo S, Ma B, Li X.   +15 more
europepmc   +1 more source

ZEB1 Promotes Oxaliplatin Resistance through the Induction of Epithelial - Mesenchymal Transition in Colon Cancer Cells [PDF]

, 2017
Cao Guo, Junli Ma, Ganlu Deng, Yanlin Qu, Ling Yin, Yiyi Li, Ying Han, Changjing Cai, Hong Shen, Shan Zeng   +9 more
openalex   +1 more source

Fucoidan: An Update on Function, Role in Human Health and Applications

Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.
Fucoidan is a promising bioactive compound with anti‐inflammatory, anticoagulant, anticancer, antioxidant, antiviral, and cardioprotective properties. In addition, thanks to its epigenetic potential, ability to modulate autophagic mechanisms and possibility adjuvant agent or bioactive component of the drug delivery systems, fucoidan is a promising ...
Sharon Critelli, Marilena Celano
wiley   +1 more source

Clinical Pharmacology and Translational Science Considerations in the Development of Dual‐Payload Antibody Drug Conjugates

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Antibody‐drug conjugates (ADCs) have evolved in the last decade or two from carrying a single chemotherapy payload to carrying highly potent tubulin inhibitors and DNA damaging agents. While the latter have shown success in the clinic, efficacy has been constrained by therapeutic resistance, limited tumor penetration, and suboptimal immune ...
Paulien Ravenstijn, Toru Kakinuma, Salaheldin Hamed, Takeshi Kadokura, Yohei Okada, Srinivasu Poondru   +5 more
wiley   +1 more source

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat. [PDF]

Oncol Rep
Röttgen H, Theurer L, Peccerella T, Sandu K, Weiss J, Burhenne J, Neoptolemos JP, Köberle B, Theile D.   +8 more
europepmc   +1 more source