Results 71 to 80 of about 3,144,476 (264)

Phase I study of azacitidine and oxaliplatin in patients with advanced cancers that have relapsed or are refractory to any platinum therapy. [PDF]

, 2015
BackgroundDemethylation process is necessary for the expression of various factors involved in chemotherapy cytotoxicity or resistance. Platinum-resistant cells may have reduced expression of the copper/platinum transporter CTR1.
Culotta, Kirk, Falchook, Gerald, Fu, Siqing, He, Guangan, Hess, Kenneth, Issa, Jean-Pierre J, Jelinek, Jaroslav, Kurzrock, Razelle, Naing, Aung, Piha-Paul, Sarina, Said, Rabih, Siddik, Zahid H, Stewart, David J, Tsimberidou, Apostolia M, Wistuba, Ignacio, Zinner, Ralph   +15 more
core   +2 more sources

Regrowth resistance: low-level platinum resistance mediated by rapid recovery from platinum-induced cell-cycle arrest [PDF]

, 2009
The H69CIS200 and H69OX400 cell lines are novel models of low-level platinum drug resistance developed from H69 human small cell lung cancer cells with eight 4-day treatments of 200 ng/ml cisplatin or 400 ng/ml oxaliplatin respectively. A recovery period
Davey, Ross, Stordal, Britta
core   +2 more sources

Fusobacterium nucleatum induces oxaliplatin resistance by inhibiting ferroptosis through E-cadherin/β-catenin/GPX4 axis in colorectal cancer.

Free Radical Biology & Medicine
Fusobacterium (F.) nucleatum is a carcinogenesis microbiota in colorectal cancer (CRC). Growing evidence shows that F. nucleatum contributes to chemoresistance.
Bowen Li, Zixian Wei, Zhiyue Wang, Fangqi Xu, Jinhua Yang, Baiqiang Lin, Yu Chen, Hubin Wenren, Lingli Wu, Xiao Guo, Yang Liu, Yunwei Wei   +11 more
semanticscholar   +1 more source

EphA2 affects the sensitivity of oxaliplatin by inducing EMT in oxaliplatin-resistant gastric cancer cells

Oncotarget, 2017
Erythropoietin-producing hepatocellular receptor A2 (EphA2) is upregulated in gastric cancer tissues and cells, which is accompanied by epithelial-mesenchymal transition (EMT). The current study was designed to establish the oxaliplatin-resistant human gastric cancer cell line SGC-7901/L-OHP, to determine if EMT in these cells could be reversed, and to
Wen, Qiaocheng, Chen, Zihua, Chen, Zhikang, Chen, Jinxiang, Wang, Ran, Huang, Changhao, Yuan, Weijie   +6 more
openaire   +2 more sources

Topoisomerase expression and amplification in solid tumours: Analysis of 24,262 patients. [PDF]

, 2017
BackgroundTopoisomerase I (TOPO1) and topoisomerase IIα (TOP2A) are specific targets of multiple chemotherapy drugs. Increased expression of TOPO1 protein and amplification of the TOP2A gene have been associated with treatment response in colorectal and ...
Arguello, David, Gatalica, Zoran, Heestand, Gregory M, Kurzrock, Razelle, Schwaederle, Maria   +4 more
core   +1 more source

Oxaliplatin for the treatment of cisplatin-resistant cancer: A systematic review [PDF]

Cancer Treatment Reviews, 2007
Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of oxaliplatin in patients with "cisplatin-resistant" cancer.
Stordal, Britta, Pavlakis, Nick, Davey, Ross   +2 more
openaire   +5 more sources

Establishment and characterization of models of chemotherapy resistance in colorectal cancer: Towards a predictive signature of chemoresistance [PDF]

, 2015
Current standard treatments for metastatic colorectal cancer (CRC) are based on combination regimens with one of the two chemotherapeutic drugs, irinotecan or oxaliplatin.
Andersen, Claus L., Beck, Mette Kristina, Belling, Kirstine C., Bosman, Fred, Brünner, Nils, Budinská, Eva, Delorenzi, Mauro, Gupta, Ramneek, Hansen, Tine P., Hanáková, Barbora, Jensen, Niels F., Moreira, José M.A., Nguyen Do, Khoa, Nygård, Sune B., Pfeiffer, Per, Rasmussen, Mads H., Roth, Arnaud, Rømer, Maria U., Stenvang, Jan, Tarpgaard, Line S., Tejpar, Sabine, Viuff, Birgitte   +21 more
core   +5 more sources

Oxidative stress activates NORAD expression by H3K27ac and promotes oxaliplatin resistance in gastric cancer by enhancing autophagy flux via targeting the miR-433-3p

Cell Death and Disease, 2021
Oxaliplatin resistance undermines its curative effects on cancer and usually leads to local recurrence. The oxidative stress induced DNA damage repair response is an important mechanism for inducing oxaliplatin resistance by activating autophagy.
Jizhao Wang, Yuchen Sun, Xing Zhang, Hui Cai, Cheng Zhang, Hangying Qu, Lin Liu, Mingxin Zhang, Junke Fu, Jia Zhang, Jiansheng Wang, Guang-jian Zhang   +11 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

LINC00460-miR-149-5p/miR-150-5p-Mutant p53 Feedback Loop Promotes Oxaliplatin Resistance in Colorectal Cancer

Molecular Therapy: Nucleic Acids, 2020
Oxaliplatin resistance is a major challenge in the clinical treatment for advanced colorectal cancer (CRC). Long non-coding RNAs (lncRNAs) are involved in tumorigenesis and progression as critical regulators, while their potential roles in ...
Xiangfeng Meng, Wu Sun, Jing Yu, Yu Zhou, Yuanyuan Gu, Jiayi Han, Likun Zhou, Xiaohong Jiang, Chen Wang   +8 more
doaj   +1 more source