Results 101 to 110 of about 24,125 (306)

1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors [PDF]

, 1983
We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to ...
Asquith, Christopher R.M., Godoi, Paulo H., Counago, Rafael M., Laitinen, Tuomo, Scott, John W., Langendorf, Christopher G., Oakhill, Jonathan S., Drewry, David H., Zuercher, William J., Koutentis, Panayiotis A., Willson, Timothy M., Kalogirou, Andreas S.   +11 more
core   +3 more sources

1′,3′,3′-Trimethyl-2,3-diphenyl-2,3-dihydroisoxazole-5(4H)-spiro-2′-indoline

Acta Crystallographica Section E, 2009
Two diastereoisomers of the title compound, C25H26N2O, have been prepared by cycloaddition between 1,3,3-trimethyl-2-methyleneindoline and C-phenyl-N-phenylnitrone. The stereochemistry of the major diastereoisomer, viz. S,R/R,S, is confirmed by the X-ray
Mohamed Azrour, Lhou Majidi, Rachid Fihi, Jean-Claude Daran, Naoual Laghrib   +4 more
doaj   +1 more source

Cation-induced ring-opening and oxidation reaction of photoreluctant spirooxazine–quinolizinium conjugates

Beilstein Journal of Organic Chemistry, 2020
Two new spiroindolinonaphthoxazine derivatives with an electron-accepting styrylquinolizinium or styrylcoralyne unit, respectively, were synthesized, and the influence of such an arylvinyl substituent on the chemical and photochemical properties of the ...
Phil M. Pithan, Sören Steup, Heiko Ihmels   +2 more
doaj   +1 more source

Non linear Prediction of Antitubercular Activity Of Oxazolines and Oxazoles derivatives Making Use of Compact TS-Fuzzy models Through Clustering with orthogonal least sqaure technique and Fuzzy identification system [PDF]

arXiv, 2014
The prediction of uncertain and predictive nonlinear systems is an important and challenging problem. Fuzzy logic models are often a good choice to describe such systems however in many cases these become complex soon. commonlly, too less effort is put into descriptor selection and in the creation of suitable local rules.
arxiv  

Reaction Kinetics of NH2 With H2CO and CH3CHO: Modeling Implications for NH3‐Dual Fuel Blends

International Journal of Chemical Kinetics, Volume 57, Issue 7, Page 403-416, July 2025.
ABSTRACT Carbon‐free fuels like ammonia (NH3) and hydrogen (H₂) offer significant potential in combating global warming by reducing greenhouse gas emissions and moving toward zero carbon emissions. Over the past few years, our research has focused on understanding the combustion behavior of carbon‐neutral and carbon‐free fuels.
Krishna Prasad Shrestha, Tam V.‐T. Mai, Sushant Giri, V. Mahendra Reddy, Milán Szőri, Rakhi Verma, Fabian Mauss, Binod Raj Giri, Lam Kim Huynh   +8 more
wiley   +1 more source

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.

Journal of Medicinal Chemistry, 2016
Histone deacetylase 6 (HDAC6) catalyzes the removal of an acetyl group from lysine residues of several non-histone proteins. Here we report the preparation of thiazole-, oxazole-, and oxadiazole-containing biarylhydroxamic acids by a short synthetic ...
J. Senger, Jelena Melesina, M. Marek, C. Romier, I. Oehme, O. Witt, W. Sippl, M. Jung   +7 more
semanticscholar   +1 more source

Crystal structure of 4,4-dimethyl-2-(trifluoromethyl)-4,5-dihydro-1H-imidazole, C6H9F3N2 [PDF]

, 2019
C6H9F3N2, monoclinic, P21/n (no. 14), a = 10.6224(9) Å, b = 11.8639(9) Å, c = 13.3139(11) Å, β = 105.903(3)°, V = 1613.6(2) Å3, Z = 8, Rgt(F) = 0.0618, wRref(F2) = 0.1629, T = 102(2) K [1–3]
Lentz, Dieter, Musa Said, A., Seraj Alzahrani, O., Warad, Ismail, Zarrouk, Abdelkader   +4 more
core   +1 more source

Thiopeptide Antibiotics: Retrospective and Recent Advances

Marine Drugs, 2014
Thiopeptides, or thiazolyl peptides, are a relatively new family of antibiotics that already counts with more than one hundred different entities.
Xavier Just-Baringo, Fernando Albericio, Mercedes Álvarez   +2 more
doaj   +1 more source

Boron in My Mind: A Comprehensive Review of the Evolution of the Diverse Syntheses of 4‐Borono‐l‐Phenylalanine, the Leading Agent for Boron Neutron Capture Therapy

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Boron Neutron Capture Therapy is a promising technique for treating “untreatable” brain cancers by having 10B nuclei absorb neutrons and then decay to 7Li destroying the cells they are in. The dominant clinical agent is 4‐borono‐l‐phenylalanine, and this review comprehensively analyzes all of its reported patent and literature syntheses to help ...
Sarfraz Ahmad, Ming Pan, John J. Hayward, Massimo Sementilli, Lisa A. Porter, John F. Trant   +5 more
wiley   +1 more source

New angular oxazole-fused coumarin derivatives: synthesis and biological activities

Natural Product Research, 2018
Twelve angular oxazole-fused coumarin derivatives were designed, synthesised and characterised by 1H NMR, 13C NMR and HRMS. The structure of compound 4a was further confirmed by X-ray single-crystal diffraction.
Y. Wei, Shi-qiang Li, Shuanghong Hao
semanticscholar   +1 more source