Results 171 to 180 of about 14,274 (205)

New oxazolidinones

Current Opinion in Microbiology, 2007
Due to the emergence of resistance to known antibiotics to various organisms, for example, Staphylococcus, Streptococcus, Enterococci, and Pseudomonas there is a renewed interest in the discovery of new antibacterials. Oxazolidinones, totally synthetic class of novel antibacterials, possess activity against drug-resistant Gram-positive pathogens ...
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The oxazolidinones

Current Infectious Disease Reports, 2002
The need for effective antibiotics to manage the ever increasing frequency of antibiotic-resistant gram-positive infections in much of the developed world has led to the clinical development of the first oxazolidinone antibiotic, linezolid. Linezolid possesses bacteriostatic activity against both antibiotic-susceptible and resistant strains of ...
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Oxazolidinones: New antibacterial agents

Trends in Microbiology, 1997
The oxazolidinones are a new chemical class of synthetic antibacterial agents that are active orally or intravenously against multidrug-resistant Gram-positive bacteria. Their unique mechanism of action and activity against bacteria that pose therapeutic problems in hospital and community treatments make them promising candidates for antimicrobial ...
C W, Ford, J C, Hamel, D, Stapert, J K, Moerman, D K, Hutchinson, M R, Barbachyn, G E, Zurenko   +6 more
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Two Oxazolidinone Derivatives

Acta Crystallographica Section C Crystal Structure Communications, 1998
The structures of two substituted oxazolidinones, namely, 4-hydroxy­methyl-4-methyloxazolidin-2-one [C5H9NO3, (1)] and 4-ethyl-4-hydroxymethyloxazolidin-2-one [C6H11NO3, (2)], are reported. Bond distances in the two structures are almost identical. The oxazolidinone rings both adopt envelope conformations; the fold in (1) is significantly larger than ...
M. W. Eknoian, T. R. Webb, S. D. Worley, J. R. Fleury, S. D. Maddox   +4 more
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Novel piperidinyloxy oxazolidinone antimicrobial agents

Bioorganic & Medicinal Chemistry Letters, 2001
Oxazolidinone antibacterial agents, where the N-substituted piperazinyl group of eperezolid was replaced with a N-substituted piperidinyloxy moiety, were synthesized and shown to be active against a variety of resistant and susceptible Gram-positive organisms.
M A, Weidner-Wells, C M, Boggs, B D, Foleno, E, Wira, K, Bush, R M, Goldschmidt, D J, Hlasta   +6 more
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Oxazolidinone-Promoted, Torquoselective Nazarov Cyclizations

Organic Letters, 2012
Oxazolidinones are powerful promoters of the Nazarov reaction, enabling the cyclization of conventionally resistant substrates to be achieved under mild conditions. They exert excellent regio- and torquoselective control in both the conventional Nazarov reaction giving cyclopentenones and in the "interrupted" Nazarov reaction, giving more highly ...
Daniel J, Kerr, Michael, Miletic, Jason H, Chaplin, Jonathan M, White, Bernard L, Flynn   +4 more
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Novel oxazolidinone–quinolone hybrid antimicrobials

Bioorganic & Medicinal Chemistry Letters, 2003
Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogues 2, 5, and 6 display an improved potency versus linezolid against gram-positive and fastidious gram-negative pathogens.
Mikhail F, Gordeev, Corinne, Hackbarth, Michael R, Barbachyn, Lee S, Banitt, James R, Gage, Gary W, Luehr, Marcela, Gomez, Joaquim, Trias, Sara E, Morin, Gary E, Zurenko, Christian N, Parker, Jonathan M, Evans, Richard J, White, Dinesh V, Patel   +13 more
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Linezolid: an oxazolidinone antimicrobial agent

Clinical Therapeutics, 2001
Linezolid is the first oxazolidinone anti-infective agent marketed in the United States. It is indicated for the treatment of nosocomial pneumonia, complicated skin and skin-structure infections caused by methicillin-sensitive or methicillin-resistant Staphylococcus aureus and other susceptible organisms, and vancomycin-resistant Enterococcus faecium ...
H B, Fung, H L, Kirschenbaum, B O, Ojofeitimi   +2 more
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Oxazolidinone: search for highly potent antibacterial

Bioorganic & Medicinal Chemistry Letters, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Braj Bhushan, Lohray, Vidya Bhushan, Lohray, Brijesh Kumar, Srivastava, Sunil, Gupta, Manish, Solanki, Prashant, Kapadnis, Vijay, Takale, Purvi, Pandya   +7 more
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3-Aryl-2-oxazolidinones through the Palladium-Catalyzed N-Arylation of 2-Oxazolidinones

Organic Letters, 2001
[reaction: see text] 3-Aryl-2-oxazolidinones are obtained in good yields through the palladium-catalyzed N-arylation of 2-oxazolidinones with aryl bromides. The nature of aryl bromides, phosphine ligands, bases, and solvents strongly affects the reaction outcome.
CACCHI, Sandro, FABRIZI, Giancarlo, GOGGIAMANI, ANTONELLA, ZAPPIA G.   +3 more
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