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Oxazolidinone Antibacterial Agents
Current Pharmaceutical Design, 1996The oxazolidinones are a new class of synthetic antibacterial agents. These compounds demonstrate potent in vitro and in vivo activity against important human pathogens, including multiple antibiotic-resistant strains of gram positive organisms including the staphylococci, streptococci, and enterococci.
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Linezolid: An oxazolidinone antimicrobial agent
American Journal of Health-System Pharmacy, 2002The pharmacology, antimicrobial activity, pharmacokinetics, clinical efficacy, and adverse effects of linezolid are reviewed. Linezolid, the only oxazolidinone antimicrobial approved for use in the United States, has significant activity against gram-positive bacteria, including penicillin-, cephalosporin-, and vancomycin-resistant species.
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Oxazolidinone Antibacterial Agents
2011The “golden age” of antibacterial agent discovery commenced with the identification of the sulfa drugs in the mid 1930s and concluded with the emergence of the quinolones in the early 1960s (Fig. 8.1). It is interesting to note that the vast majority of these early antibiotics were derived from natural products.
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[Oxazolidinones and glycopeptides].
Enfermedades infecciosas y microbiologia clinica, 2003We review the chemical structure, pharmacokinetics, antimicrobial spectrum, mechanisms of action and resistance, clinical use and adverse effects of oxazolidinones (linezolid) and glycopeptides. Oxazolidinones inhibit protein synthesis and glycopeptides cell wall synthesis.
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Diagnostic Microbiology and Infectious Disease, 1992
William Brumfitt +1 more
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William Brumfitt +1 more
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