Results 101 to 110 of about 10,637 (203)

Remodelling of the natural product fumagillol employing a reaction discovery approach [PDF]

, 2011
In the search for new biologically active molecules, diversity-oriented synthetic strategies break through the limitation of traditional library synthesis by sampling new chemical space. Many natural products can be regarded as intriguing starting points
Balthaser, Bradley R., Beeler, Aaron B., Maloney, Meghan C., Porco, John A., Snyder, John K.   +4 more
core   +1 more source

Linezolid: The First Oxazolidinone Antimicrobial

Annals of Internal Medicine, 2003
Linezolid is the first of a new class of antimicrobial agents, the oxazolidinones, to be approved for clinical use in the United States and elsewhere. The drug is a totally synthetic compound, which lessens the likelihood of naturally occurring resistance mechanisms.
openaire   +2 more sources

Multicenter assessment of the linezolid spectrum and activity using the disk diffusion and Etest methods: report of the Zyvox® Antimicrobial Potency Study in Latin America (LA-ZAPS)

Brazilian Journal of Infectious Diseases, 2002
Linezolid was the first clinically applied member of the new antimicrobial class called the "oxazolidinones". These agents have a powerful spectrum of activity focussed against Gram-positive organisms including strains with documented resistances to ...
Ballow Charles H., Biedenbach Douglas J., Rossi Flavia, Jones Ronald N.   +3 more
doaj  

Sm₂XMnO₆ (X = Co, Cr, and Fe) linked HPG on dendritic nanosilica as a recyclable green catalyst for eco-friendly synthesis of oxazolidinones from carbon dioxide

Journal of CO2 Utilization
In this work, Sm₂XMnO₆ (X = Co, Cr, Fe) nanocatalysts with high surface area and readily accessible active sites were successfully synthesized using a simple strategy based on dendritic fibrous nanosilica (DFNS).
Jianshan Li, Jiuzheng Yu, Rahele Zhiani
doaj   +1 more source

Linezolid and Rifampicin Combination to Combat cfr-Positive Multidrug-Resistant MRSA in Murine Models of Bacteremia and Skin and Skin Structure Infection. [PDF]

, 2019
Linezolid resistance mediated by the cfr gene in MRSA represents a global concern. We investigated relevant phenotype differences between cfr-positive and -negative MRSA that contribute to pathogenesis, and the efficacy of linezolid-based combination ...
Li, Liang, Liao, Xiao-Ping, Liu, Ya-Hong, Sun, Jian, Tao, Meng-Ting, Xiong, Yan Q, Zhou, Yu-Feng   +6 more
core  

Linezolid Susceptibility And Potential Resistance Mechanisms Among Mrsa Isolated From Two Major Public Hospitals In Malaysia [PDF]

, 2014
Linezolid is the first antibiotic of a new structural class, the oxazolidinones, to be approved for clinical use in 35 years. This antimicrobial agent is broadly effective against drug-resistant gram-positive pathogens which commonly cause infections ...
Thiruchelvi , Pulingam
core  

Identification of the Phenicol Efflux Gene <i>fexB</i> and Its Co-Occurrence With the Oxazolidinone/Phenicol Resistance Gene <i>optrA</i> in Avian <i>Campylobacter jejuni</i> Isolates From Tunisia. [PDF]

Int J Microbiol
Gharbi M, Hamdi C, Abbas MAS, Hamrouni S, Maaroufi A.   +4 more
europepmc   +1 more source

Efficient and sustainable fixation of CO₂ into 2-oxazolidinones utilizing ionic liquid functionalized SiO₂ nanocomposites. [PDF]

BMC Chem
Hu Y, Lin S, Liu X.
europepmc   +1 more source

The Structure, Properties, and Clinical Utility of Contezolid for Antituberculosis: A Narrative Review. [PDF]

Infect Dis Ther
Chen T, Li W, Shen F, Nie W, Wu F.
europepmc   +1 more source

Hybrid Antibiotics Targeting the Bacterial Ribosome. [PDF]

ACS Cent Sci
Yeon SK, Pellegrino J, Raskar T, Tran MLN, Dandan M, Guérin F, Einsiedler M, Cattoir V, Fraser JS, Seiple IB.   +9 more
europepmc   +1 more source