Results 111 to 120 of about 16,479 (221)

Monographs on drugs which are frequently analyzed in therapeutic drug monitoring [PDF]

, 2017
In addition to the monographs which have been published in the past 4 years by the working group "Drug Monitoring” of the Swiss Society of Clinical Chemistry (SSCC) [1-4], new monographs have been written.
Buhl, Daniela, Eap, Chin Bin, Fathi, Marc, Jöchle, Wolfgang, Magnin, Jean-Luc, Rentsch, Working group "Drug Monitoring” of the SSCC: Katharina, Thormann, Wolfgang, Werner, Dominique   +7 more
core  

Clozapine for treatment‐resistant schizophrenia with epilepsy: A case report

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
Clozapine (CLOZ) is often avoided in treatment‐resistant schizophrenia with comorbid epilepsy due to seizure risks. We report a successful case managed through a cautious CLOZ titration guided by multimodal monitoring, including clinical scales and blood tests such as C‐reactive protein (CRP), CLOZ levels, and anti‐seizure medication (ASM) levels ...
Toru Horinouchi, Mayusa Mito, Toshiyuki Ishikawa, Yuichi Nakamura, Shuhei Ishikawa, Naoki Hashimoto   +5 more
wiley   +1 more source

Agitation in Nonverbal Patients With Autism: The Role of Sensory Evaluation in Diagnosis and Management

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Autism spectrum disorder (ASD) is a complex neurodevelopmental condition often associated with communication barriers, sensory sensitivities, and behavioral challenges, including agitation. Identifying the underlying causes of acute agitation in nonverbal individuals with ASD can be difficult, leading to diagnostic delays and unnecessary ...
Logan Bailey, Justin David Tse, Amitesh Chandra, Sylvia Sudat, Rajkamal Hansra   +4 more
wiley   +1 more source

Single‐nucleus RNA sequencing reveals ferroptosis as a potential contributor to the pathogenesis of focal cortical dysplasia

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
1. A single‐cell analysis was conducted to investigate the transcriptomic changes in cells within focal cortical dysplasia (FCD). 2. Ferroptosis may play a significant role in the pathogenesis of FCD, potentially contributing to cellular damage and epileptogenesis. 3.
Qingyang Zeng, Fengjun Zhu, Dezhi Cao, Yang Sun, Lin Li, Zeshi Tan, Cong Li, Xiaofan Ren, Yidi Liu, Zhiqiang Lin, Dongfang Zou   +10 more
wiley   +1 more source

The efficacy of ultrasound-guided pulsed radiofrequency in the treatment of primary glossopharyngeal neuralgia

Frontiers in Neurology
ObjectiveThis study evaluates the clinical efficacy and safety of ultrasound-guided long duration, high voltage pulse radiofrequency (PRF) in managing primary glossopharyngeal neuralgia (GPN).MethodsClinical data were retrospectively analyzed for 13 ...
Fubo Li, Hongcheng Lu, Gege Gong, Cehua Ou, Yue Zhang   +4 more
doaj   +1 more source

SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION CAUSED BY OXCARBAZEPINE THERAPY: A CASE REPORT

Psychiatry and Clinical Psychopharmacology, 2021
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) may be associated with several situations and psychotropic drugs e.g., carbamazepine (CBZ), neuroleptics, tricyclic antidepressants, methyldopa and more recently selective serotonin ...
Ali Savaş Çilli, Ekrem Algün
doaj  

Should PNPO Deficiency Be Treated In Utero? Clinical Findings From Prenatal Pyridoxine Therapy

JIMD Reports, Volume 67, Issue 3, May 2026.
ABSTRACT Pyridox(am)ine‐5′‐phosphate oxidase (PNPO) deficiency is characterized by early‐onset epileptic encephalopathy refractory to standard antiseizure medications. It is caused by variants in the PNPO gene, resulting in deficient PNPO enzyme activity, which normally converts pyridoxine‐5′‐phosphate and pyridoxamine‐5′‐phosphate (two vitamers of ...
Chloé de Puyraimond, Samia Pichard, Muriel Girard, Julian Delanne, Laurence Faivre, Apolline Imbard, Amandine Baurand, Jean‐François Benoist, Philippa B. Mills, Peter T. Clayton, Manuel Schiff   +10 more
wiley   +1 more source

Antenatal diagnosis and maternal sirolimus treatment of polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Background Polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome is a rare autosomal recessive mTORopathy caused by biallelic STE20‐related kinase adaptor alpha (STRADA) loss‐of‐function variants. Animal models demonstrate that in utero mechanistic target of rapamycin (mTOR) inhibition can prevent cortical dyslamination ...
Christian Macedonia, Vincent J. Carson, D. Holmes Morton, Karin J. Blakemore, Mark I. Evans, Peter B. Crino   +5 more
wiley   +1 more source

The Effect of the Anticonvulsant Topiramate on Acetylcholine‐Induced Calcium Signals is Linked to Sirt‐1 Activity

European Journal of Neuroscience, Volume 63, Issue 9, May 2026.
This work provides a potential new link between the anticonvulsive Topiramate, the deacetylase Sirt‐1 and the cholinergic signalling, suggesting that Topiramate may modulate cholinergic pathways in a Sirt‐1 depended manner. ABSTRACT Although some forms of epilepsy directly result from mutations in nicotinic acetylcholine receptors, none of the ...
Marie‐Luise Kümmel
wiley   +1 more source

Efficacy and safety of levetiracetam vs. oxcarbazepine in the treatment of children with epilepsy: a systematic review and meta-analysis

Frontiers in Pediatrics
BackgroundLevetiracetam (LEV) and oxcarbazepine (OXC) are new antiseizure medications (ASMs). In recent years, OXC monotherapy is widely used in children with epilepsy; however, no consensus exists on applying LEV monotherapy among children with epilepsy.
Yuanyuan Liu, Yanxu Wang, Xingzhou Li, Xiaomin Wu   +3 more
doaj   +1 more source