Results 21 to 30 of about 12,078 (208)
Paroxysmal Kinesigenic Dyskinesia and Progressive Ataxia-Spasticity Syndrome Caused by a Biallelic Variant in KCNJ10. [PDF]
Mov Disord Clin PractMovement Disorders Clinical Practice, EarlyView.
Desjardins C +9 more
europepmc +2 more sources
The gut microbiome and drug-resistant epilepsy: Microbiome-antiseizure medication interactions and implications for pharmacoresistance. [PDF]
Epilepsia OpenAbstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Zammar K +4 more
europepmc +2 more sources
Epilepsia, 1999 Summary:The success of carbamazepine (CBZ) as a broad‐spectrum antiepileptic drug (AED) has led to its use as first‐line therapy in children and adults for partial and generalized tonic‐clonic seizures. The limitations of CBZ include toxicity in sensitive individuals, autoinduction, which requires dose adjustment when therapy is initiated, and chronic ...
openaire +2 more sources
Safety profile of oxcarbazepine: results from a prescription-event monitoring study [PDF]
, 2010 Purpose: To monitor safety of oxcarbazepine, prescribed in primary care in England, using prescription-event monitoring (PEM). Methods: Postmarketing surveillance using observational cohort technique of PEM.
Layton, D. +3 more
core +1 more source
Response to anti-seizure medications in children carrying novel or previously reported HCN1 gene variants. [PDF]
Epilepsia OpenAbstract Objective Variants in the HCN1 gene cause a syndrome of childhood epilepsy and developmental disability with a broad phenotypic range. Many affected children manifest with early infantile epileptic encephalopathy (EIEE) and highly drug‐resistant epilepsy.
Khan MN, Poolos NP.
europepmc +2 more sources
Anticonvulsants in the treatment of aggression in the demented elderly : an update [PDF]
, 2009 Introduction Complex psychopathological and behavioral symptoms, such as delusions and aggression against care providers, are often the primary cause of acute hospital admissions of elderly patients to emergency units and psychiatric departments.
Ana Gonzalez-Pinto +18 more
core +1 more source
Three types of atrioventricular block induced by oxcarbazepine in a young adult
Psychiatry and Clinical Psychopharmacology, 2021 Oxcarbazepine is a new antiepileptic drug that has been introduced recently. The side effects and properties of the drug are unique and largely unknown. Because oxcarbazepine is structurally similar to carbamazepine, it might have quinidine-like effects
Edibe Karasu, Ahmet Oguz Baktir
doaj +1 more source
Oxcarbazepine in Monotherapy [PDF]
Behavioural Neurology, 1990 Altogether 235 patients with newly diagnosed epilepsy were randomly allocated to treatment with either oxcarbazepine (OXC) or carbamazepine (CBZ) in a double-blind multicentre trial. After a titration phase of 4–8 weeks the optimum individual dose of trial medication was determined and treatment with this dose was continued for another 48 weeks.
openaire +3 more sources
Current Issues in Pharmacy and Medical Sciences, 2009 The aim of this study was to assess the influence of verapamil (an L-type calcium channel blocker) on the anticonvulsant potential of oxcarbazepine (a second-generation antiepileptic drug) in the maximal electroshock seizure (MES) test in mice ...
Anna Zadrożniak +6 more
doaj +1 more source
Brain Sciences, 2019 Oxcarbazepine, an antiepileptic drug, has been reported to modulate voltage-dependent sodium channels, and it is commonly used in epilepsy treatment.
Ji Hyeon Ahn +11 more
doaj +1 more source