Roles of Oxidative Stress in Synaptic Dysfunction and Neuronal Cell Death in Alzheimer’s Disease
Alzheimer’s disease (AD) is a brain disorder that progressively undermines memory and thinking skills by affecting the hippocampus and entorhinal cortex.
Germán Plascencia-Villa, George Perry
doaj +1 more source
Massive production of graphene oxide from expanded graphite [PDF]
In a deviation from the conventional Hummers method, a spontaneous expansion approach was introduced with expanded graphite as the precursors. The intercalating agent (H2SO4) was able to penetrate into the expanded graphite; this had further expanded the
Fugetsu, Bunshi, Sun, Ling
core +2 more sources
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah +8 more
wiley +1 more source
AAD-2004, a potent spin trapping molecule and microsomal prostaglandin E synthase-1 inhibitor, shows safety and efficacy in a mouse model of ALS [PDF]
While free radicals and inflammation constitute major routes of neuronal injury occurring in neurodegenerative diseases, neither antioxidants nor nonsteroidal anti-inflammatory drugs (NSAIDs) have shown significant efficacy in human clinical trials.
Bok Yun +12 more
core +1 more source
Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes [PDF]
Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange reactions to reduce proteins with disulfide bonds. As such, Trx1 helps protect the heart against stresses, such as ischemia and pressure overload.
Bhat, Santosh +16 more
core +1 more source
The tribological behavior of 100Cr6 steel spheres textured via Vickers microindentation is evaluated under lubricated sliding by varying both dimple size and density. Fine and dense textures significantly reduce friction across all lubrication regimes, while large dimples increase it.
Farideh Davoodi +3 more
wiley +1 more source
Endogenous Oxidants and Antioxidants in Human Body
The review presents general modern conception of endogenous oxidants and antioxidant system in human body, shows their participation in non-specific protection of the body against infectious agents.
O.Ye. Abaturov +2 more
doaj +1 more source
Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines [PDF]
Objective - Although inflammation is a recognized feature of atherosclerosis, the impact of inflammation on cellular cholesterol homeostasis is unclear.
Ma, KL +6 more
core +1 more source
Pretreatment of secondary effluents in view of optimal ozone-based AOP removal of trace organic contaminants : bench-scale comparison of efficiency and energy consumption [PDF]
This study compares the performance of several ozone-based advanced oxidation processes (AOPs), in combination with filtration, in terms of trace organic contaminant (TrOC) removal efficiency and energy and cost requirement.
Demeestere, Kristof +2 more
core +1 more source
Powder metal processing provides scalable advantages in nanoporous (np) metal development. Mechanical alloying is used to produce unique precursors for hybrid nanopore formation by oxide reduction and dealloying. As demonstrated in np Ag, this approach improves process efficiency while promoting smaller ligaments and larger pores, both of which are ...
Mark A. Atwater, Oliver A. Fowler
wiley +1 more source

