Results 251 to 260 of about 3,315,390 (285)

Mechanism of Oxidative Phosphorylation

Nature, 1958
THE phenothiazine tranquillizer chlorpromazine has the following actions: (1) It inhibits electron transport between reduced diphosphopyridine nucleotide and cytochrome c in appropriate systems; the efficiency of the coupled phosphorylation is not affected. (2) Chlorpromazine is not effective in mitochondria treated with water or in non-phosphorylating
M J, DAWKINS, J D, JUDAH, K R, REES
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Efficiency of Oxidative Phosphorylation

Nature, 1954
THE quantitative yield of phosphate fixed during cellular oxidations deserves critical investigation, for it determines the efficiency with which utilizable energy may be derived from assimilated foodstuffs and it may influence metabolic regulatory mechanisms1. This problem has been the subject of many investigations (cf. Krebs et al.
H, LARDY, J H, COPENHAVER
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Oxidative Phosphorylation in Mitochondria

Annual Review of Biochemistry, 1969
INTRODUCTION. • • • • • • • • • • • • • • • • • • • • • • • • • • • • . • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • 991 ELECTRON TRANSPORT AND COUPLING SITES. • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • 991 PROTEIN FACTORS THAT COUPLE RESPIRATION WITH PHOSPHORYLATION. • • • • • • • • • • 999 Phosphoryl tran rerases.
H A, Lardy, S M, Ferguson
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Oxidative phosphorylation and aging

Ageing Research Reviews, 2006
This review addresses the data that support the presence and contribution of decreased mitochondrial oxidative phosphorylation during aging to impaired cellular metabolism. Aging impairs substrate oxidation, decreases cellular energy production and increases the production of reactive intermediates that are toxic to the cell.
Edward J, Lesnefsky, Charles L, Hoppel
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OXIDATIVE PHOSPHORYLATION

Australian Journal of Experimental Biology and Medical Science, 1958
Albert L. Lehninger, Charles L. Wadkins, James L. Gamble, Cecil Cooper, Thomas M. Devlin   +4 more
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Oxidative Phosphorylation Disease Diagnosis

Seminars in Neurology, 1999
ABSTRACT: Although the mtDNA encodes only 13 polypeptide subunits of the OXPHOS enzymes, approximately 1,000 proteins are estimated to be necessary for proper OXPHOS function. Over the past 10 years a wide variety of adult and pediatric OXPHOS diseases were found to be caused by or associated with mitochondrial DNA (mtDNA) mutations and nuclear DNA ...
openaire   +3 more sources

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Nature Genetics, 2003
V. Mootha, C. Lindgren, K. Eriksson, A. Subramanian, S. Sihag, J. Lehár, P. Puigserver, E. Carlsson, M. Ridderstråle, E. Laurila, N. Houstis, M. Daly, N. Patterson, J. Mesirov, T. Golub, P. Tamayo, B. Spiegelman, E. Lander, J. Hirschhorn, D. Altshuler, L. Groop   +20 more
semanticscholar   +1 more source

Oxidative Phosphorylation

Annual Review of Biochemistry, 1962
A L, LEHNINGER, C L, WADKINS
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Uncouplers of oxidation phosphorylation

Pharmacology & Therapeutics, 1980
Abstract Numerous compounds, covering a broad range of chemical structures, selectively interfere with the mitochondrial mechanism for transforming energy derived from oxidative metabolism into regeneration of ATP. Within some chemical classes, structure-activity correlations have been useful.
openaire   +3 more sources

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

Nature Medicine, 2018
J. Molina, Yuting Sun, Marina Protopopova, S. Gera, Madhavi Bandi, C. Bristow, Timothy J. McAfoos, Pietro Morlacchi, J. Ackroyd, Ahmed-Noor A. Agip, G. Al-Atrash, J. Asara, Jennifer P Bardenhagen, Caroline C. Carrillo, C. Carroll, Edward Q. Chang, S. Ciurea, J. Cross, B. Czako, Angela Deem, Naval G. Daver, J. D. de Groot, Jianwen Dong, Ningping Feng, G. Gao, J. Gay, M. Do, J. Greer, Virginia Giuliani, Jingchao Han, Lina Han, V. Henry, J. Hirst, Shan Huang, Yongying Jiang, Zhijun Kang, T. Khor, S. Konoplev, Yu-Hsi Lin, Gang Liu, A. Lodi, Timothy E. Lofton, Helen Ma, Mikhila Mahendra, Polina R Matre, Robert A. Mullinax, M. Peoples, A. Petrocchi, J. Rodriguez-Canale, Riccardo Serreli, T. Shi, Melinda G. Smith, Y. Tabe, Jay P Theroff, S. Tiziani, Quanyu Xu, Qi Zhang, Florian Muller, R. DePinho, C. Toniatti, G. Draetta, T. Heffernan, M. Konopleva, Philip D. Jones, M. Di Francesco, J. Marszalek   +65 more
semanticscholar   +1 more source