Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes [PDF]
, 2017 Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange reactions to reduce proteins with disulfide bonds. As such, Trx1 helps protect the heart against stresses, such as ischemia and pressure overload.
Bhat, Santosh +16 more
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Disease Models & Mechanisms, 2015 Adipogenesis is accompanied by differentiation of adipose tissue-derived stem cells to adipocytes. As part of this differentiation, biogenesis of the oxidative phosphorylation system occurs.
Laura Llobet +4 more
doaj +1 more source
Protein kinase D1 (PKD1) phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress. [PDF]
PLoS ONE, 2014 Oxidative stress is a major pathophysiological mediator of degenerative processes in many neurodegenerative diseases including Parkinson's disease (PD).
Arunkumar Asaithambi +6 more
doaj +1 more source
Respiratory chain complex I is related to oxidative phosphorylation in gastric cancer stem cells
STEMedicine, 2022 Background: Cancer stem cells (CSCs) are the main cause of resistance to anti-cancer drug therapy and distant metastasis of tumors, including gastric cancer. The metabolism of CSCs is an important factor in the maintenance of its stemness. This study is
Chunwei Peng, Weibiao Kang, Yunsong Li
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STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]
, 2018 Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F +7 more
core +2 more sources
Unveiling ADP-binding sites and channels in respiratory complexes: Validation of Murburn concept as a holistic explanation for oxidative phosphorylation [PDF]
Journal of Biomolecular Structure and Dynamics, 2018, 2018 Mitochondrial oxidative phosphorylation (mOxPhos) makes ATP, the energy currency of life. Chemiosmosis, a proton centric mechanism, advocates that Complex V harnesses a transmembrane potential (TMP) for ATP synthesis. This perception of cellular respiration requires oxygen to stay tethered at Complex IV (an association inhibited by cyanide) and ...
arxiv +1 more source
Cell Reports, 2017 We discovered that induced pluripotent stem cell (iPSC) clones generated from aged tissue donors (A-iPSCs) fail to suppress oxidative phosphorylation. Compared to embryonic stem cells (ESCs) and iPSCs generated from young donors (Y-iPSCs), A-iPSCs show ...
Cheng Zhang +6 more
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Rosamines targeting the cancer oxidative phosphorylation pathway. [PDF]
PLoS ONE, 2014 Reprogramming of energy metabolism is pivotal to cancer, so mitochondria are potential targets for anticancer therapy. A prior study has demonstrated the anti-proliferative activity of a new class of mitochondria-targeting rosamines.
Siang Hui Lim +5 more
doaj +1 more source
Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells. [PDF]
, 2013 Work in our lab is supported by the Medical Research Council [New Investigator Research Grant G1100165 to CA] and Plymouth University [PhD studentship to JB] The final version of record is available at http://www.biochemj.org/bj/456/bj4560417.htmHigh ...
Affourtit, C, Barlow, J
core +2 more sources
Molecular responses of mouse macrophages to copper and copper oxide nanoparticles inferred from proteomic analyses [PDF]
Mol Cell Proteomics 12, 11 (2013) 3108-22, 2013 The molecular responses of macrophages to copper-based nanoparticles have been investigated via a combination of proteomic and biochemical approaches, using the RAW264.7 cell line as a model. Both metallic copper and copper oxide nanoparticles have been tested, with copper ion and zirconium oxide nanoparticles used as controls.
arxiv +1 more source