Results 31 to 40 of about 3,315,390 (285)
Protein kinase D1 (PKD1) phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress. [PDF]
PLoS ONE, 2014 Oxidative stress is a major pathophysiological mediator of degenerative processes in many neurodegenerative diseases including Parkinson's disease (PD).
Arunkumar Asaithambi +6 more
doaj +1 more source
Disease Models & Mechanisms, 2015 Adipogenesis is accompanied by differentiation of adipose tissue-derived stem cells to adipocytes. As part of this differentiation, biogenesis of the oxidative phosphorylation system occurs.
Laura Llobet +4 more
doaj +1 more source
Respiratory chain complex I is related to oxidative phosphorylation in gastric cancer stem cells
STEMedicine, 2022 Background: Cancer stem cells (CSCs) are the main cause of resistance to anti-cancer drug therapy and distant metastasis of tumors, including gastric cancer. The metabolism of CSCs is an important factor in the maintenance of its stemness. This study is
Chunwei Peng, Weibiao Kang, Yunsong Li
doaj +1 more source
Cell Reports, 2017 We discovered that induced pluripotent stem cell (iPSC) clones generated from aged tissue donors (A-iPSCs) fail to suppress oxidative phosphorylation. Compared to embryonic stem cells (ESCs) and iPSCs generated from young donors (Y-iPSCs), A-iPSCs show ...
Cheng Zhang +6 more
doaj +1 more source
Science Translational Medicine, 2019 Targeting oxidative phosphorylation overcomes ibrutinib resistance in mantle cell lymphoma. Dismantling lymphoma metabolism Mantle cell lymphoma is a B cell malignancy that often responds to initial treatment with ibrutinib, an inhibitor of Bruton’s ...
L. Zhang +30 more
semanticscholar +1 more source
PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation
Protein & Cell, 2019 A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are
Tong Li +5 more
semanticscholar +1 more source
Oxidative phosphorylation as a potential therapeutic target for cancer therapy
International Journal of Cancer, 2019 In contrast to prior belief, cancer cells require oxidative phosphorylation (OXPHOS) to strive, and exacerbated OXPHOS dependency frequently characterizes cancer stem cells, as well as primary or acquired resistance against chemotherapy or tyrosine ...
V. Sica +3 more
semanticscholar +1 more source
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation
Cell ResearchOxidative phosphorylation (OXPHOS) consumes oxygen to produce ATP. However, the mechanism that balances OXPHOS activity and intracellular oxygen availability remains elusive.
Yunzi Mao +16 more
semanticscholar +1 more source
Oxidative Stress Signaling in Blast TBI-Induced Tau Phosphorylation
Antioxidants, 2021 Traumatic brain injury caused by blast is associated with long-term neuropathological changes including tau phosphorylation and pathology. In this study, we aimed to determine changes in initial tau phosphorylation after exposure to a single mild blast ...
Chunyu Wang +10 more
doaj +1 more source
Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation
eLife, 2019 Proliferating cells often have increased glucose consumption and lactate excretion relative to the same cells in the quiescent state, a phenomenon known as the Warburg effect.
Cong-Hui Yao +5 more
semanticscholar +1 more source