MicroRNA‐661 modulates redox and metabolic homeostasis in colon cancer
Molecular Oncology, 2017 Cancer cell survival and metastasis are dependent on metabolic reprogramming that is capable of increasing resistance to oxidative and energetic stress. Targeting these two processes can be crucial for cancer progression.
Marta Gómez de Cedrón +8 more
doaj +1 more source
Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery
Pathogens, 2018 Mycobacterium tuberculosis (Mtb) exhibits remarkable metabolic flexibility that enables it to survive a plethora of host environments during its life cycle.
Iram Khan Iqbal +3 more
doaj +1 more source
STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]
, 2018 Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F +7 more
core +2 more sources
The First Korean case of combined oxidative phosphorylation deficiency-17 diagnosed by clinical and molecular investigation [PDF]
Korean Journal of Pediatrics, 2017 Combined oxidative phosphorylation deficiency-17 (COXPD-17) is very rare and is caused by homozygous or compound heterozygous mutations in the ELAC2 gene on chromosome 17p12.
Young A Kim +3 more
doaj +1 more source
Frontiers in Immunology, 2022 Excessive alcohol use increases the risk of developing respiratory infections partially due to impaired alveolar macrophage (AM) phagocytic capacity.
Niya L. Morris +9 more
doaj +1 more source
Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes [PDF]
, 2017 Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange reactions to reduce proteins with disulfide bonds. As such, Trx1 helps protect the heart against stresses, such as ischemia and pressure overload.
Bhat, Santosh +16 more
core +1 more source
Protein kinase D1 (PKD1) phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress. [PDF]
PLoS ONE, 2014 Oxidative stress is a major pathophysiological mediator of degenerative processes in many neurodegenerative diseases including Parkinson's disease (PD).
Arunkumar Asaithambi +6 more
doaj +1 more source
Correlation of structure and function in the oxidative phosphorylation system of submitochondrial particles [PDF]
, 1969 1. After the centrifugation of sonicated heavy beef heart mitochondria at 75, 000 × g for 10 minutes, the supernatant was centrifuged at 144, 000 × g for 30 minutes. The residue was revealed being composed of vesicular inner membrane fragments (
Goto, Nobuyuki +3 more
core +1 more source
Rosamines targeting the cancer oxidative phosphorylation pathway. [PDF]
PLoS ONE, 2014 Reprogramming of energy metabolism is pivotal to cancer, so mitochondria are potential targets for anticancer therapy. A prior study has demonstrated the anti-proliferative activity of a new class of mitochondria-targeting rosamines.
Siang Hui Lim +5 more
doaj +1 more source
Nature Communications, 2018 Hepatocellular carcinoma (HCC) cells are metabolically distinct from normal hepatocytes by expressing the high-affinity hexokinase (HK2) and suppressing glucokinase (GCK). This is exploited to selectively target HCC.
Dannielle C. DeWaal +9 more
semanticscholar +1 more source