Results 31 to 40 of about 3,781,647 (383)
Uncouplers of oxidative phosphorylation. [PDF]
Environmental Health Perspectives, 1990 Uncouplers of oxidative phosphorylation in mitochondria inhibit the coupling between the electron transport and phosphorylation reactions and thus inhibit ATP synthesis without affecting the respiratory chain and ATP synthase (H(+)-ATPase). Miscellaneous compounds are known to be uncouplers, but weakly acidic uncouplers are representative because they ...
openaire +4 more sources
Science Signaling, 2020 Mitochondrial Ca2+ influx promotes oxidative phosphorylation–independent pathways to enable cancer cell survival. Staying alive without oxidative phosphorylation Oxidative phosphorylation is used by many cell types to produce ATP and requires low-level ...
C. Cárdenas +20 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance We demonstrate that Akt phosphorylation of Mdm2 protein at Ser183 inhibits p53-mediated senescence and promotes ROS-induced tumorigenesis. Thus, different effector kinases can modify Mdm2 and selectively regulate the p53-mediated response to
Loretah Chibaya +3 more
semanticscholar +1 more source
DN200434 Inhibits Vascular Smooth Muscle Cell Proliferation and Prevents Neointima Formation in Mice after Carotid Artery Ligation [PDF]
Endocrinology and Metabolism, 2022 Background Excessive proliferation and migration of vascular smooth muscle cells (VSMCs), which contributes to the development of occlusive vascular diseases, requires elevated mitochondrial oxidative phosphorylation to meet the increased requirements ...
Sudeep Kumar +9 more
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Correlation of structure and function in the oxidative phosphorylation system of submitochondrial particles [PDF]
, 1969 1. After the centrifugation of sonicated heavy beef heart mitochondria at 75, 000 × g for 10 minutes, the supernatant was centrifuged at 144, 000 × g for 30 minutes. The residue was revealed being composed of vesicular inner membrane fragments (
Goto, Nobuyuki +3 more
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MicroRNA‐661 modulates redox and metabolic homeostasis in colon cancer
Molecular Oncology, 2017 Cancer cell survival and metastasis are dependent on metabolic reprogramming that is capable of increasing resistance to oxidative and energetic stress. Targeting these two processes can be crucial for cancer progression.
Marta Gómez de Cedrón +8 more
doaj +1 more source
Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery
Pathogens, 2018 Mycobacterium tuberculosis (Mtb) exhibits remarkable metabolic flexibility that enables it to survive a plethora of host environments during its life cycle.
Iram Khan Iqbal +3 more
doaj +1 more source
The First Korean case of combined oxidative phosphorylation deficiency-17 diagnosed by clinical and molecular investigation [PDF]
Korean Journal of Pediatrics, 2017 Combined oxidative phosphorylation deficiency-17 (COXPD-17) is very rare and is caused by homozygous or compound heterozygous mutations in the ELAC2 gene on chromosome 17p12.
Young A Kim +3 more
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Frontiers in Immunology, 2022 Excessive alcohol use increases the risk of developing respiratory infections partially due to impaired alveolar macrophage (AM) phagocytic capacity.
Niya L. Morris +9 more
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Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes [PDF]
, 2017 Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange reactions to reduce proteins with disulfide bonds. As such, Trx1 helps protect the heart against stresses, such as ischemia and pressure overload.
Bhat, Santosh +16 more
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