Results 61 to 70 of about 7,944,686 (390)
Cell Reports, 2020 Summary: Cells have developed protein quality-control strategies to manage the accumulation of misfolded substrates during heat stress. Using a soluble reporter of misfolding in fission yeast, Rho1.C17R-GFP, we demonstrate that upon mild heat shock, the ...
Margarita Cabrera +6 more
doaj +1 more source
Antioxidants, 2023 Non-alcoholic fatty liver disease (NAFLD) is a complex and increasingly prevalent cardiometabolic disorder worldwide. As of today, NAFLD is a pathology without specific pharmacological treatment, with the Mediterranean diet (MedDiet) being the most ...
Margalida Monserrat-Mesquida +8 more
doaj +1 more source
DNA 3 '-Phosphatase Activity Is Critical for Rapid Global Rates of Single-Strand Break Repair following Oxidative Stress [PDF]
, 2009 Oxidative stress is a major source of chromosome single-strand breaks (SSBs), and the repair of these lesions is retarded in neurodegenerative disease. The rate of the repair of oxidative SSBs is accelerated by XRCC1, a scaffold protein that is essential
Breslin, Claire, Caldecott, Keith W
core +2 more sources
Oxidative Stress in Cancer Cell Metabolism
Antioxidants, 2021 Reactive oxygen species (ROS) are important in regulating normal cellular processes whereas deregulated ROS leads to the development of a diseased state in humans including cancers.
Saniya Arfin +7 more
semanticscholar +1 more source
Redox Biology, 2020 Signaling cascades respond to specific inputs, but also require active interventions to be maintained in their basal/inactive levels in the absence of the activating signal(s).
Luis Marte +5 more
doaj +1 more source
Endothelial preconditioning by transient oxidative stress reduces inflammatory responses of cultured endothelial cells to TNF-α [PDF]
, 2000 Brief episodes of ischemia can render an organ resistant to subsequent severe ischemia. This ‘ischemic preconditioning’ is ascribed to various mechanisms, including oxidative stress. We investigated whether preconditioning exists on an endothelial level.
Akimitsu T. +11 more
core +1 more source
The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging
Oxidative Medicine and Cellular Longevity, 2021 Oxidative stress, a term that describes the imbalance between oxidants and antioxidants, leads to the disruption of redox signals and causes molecular damage.
Chao Yu, Jian-Hui Xiao
semanticscholar +1 more source
World Allergy Organization Journal, 2011 Asthma is a chronic inflammatory lung disease that results in airflow limitation, hyperreactivity, and airway remodeling. There is strong evidence that an imbalance between the reducing and oxidizing systems favoring a more oxidative state is present in asthma. Endogenous and exogenous reactive oxygen species, such as superoxide anion, hydroxyl radical,
Umit Murat Sahiner +5 more
openaire +5 more sources
Biomolecules, 2023 Recent years have seen an increased interest in the role of oxidative stress (OS) in pregnancy. Pregnancy inherently heightens susceptibility to OS, a condition fueled by a systemic inflam-matory response which culminates in an elevated presence of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the circulatory system.
Konrad Grzeszczak +4 more
openaire +3 more sources
Nature Communications, 2019 Reliable methods of measuring intracellular H2O2 fluctuations are necessary to advance redox biology. Here the authors design a H2O2 sensor based on the fission yeast peroxiredoxin Tpx1 to sense nanomolar fluctuations of intracellular H2O2 in response to
Mercè Carmona +8 more
doaj +1 more source