Results 261 to 270 of about 75,484 (307)

Familial aggregation of LDL oxidation

Scandinavian Journal of Clinical and Laboratory Investigation, 1997
The "oxidation hypothesis" states that oxidative modification of low-density lipoprotein (LDL) is important in the pathogenesis of the atherosclerotic lesion. We studied 15 families (fathers, mothers and male twins of 16 to 18 years of age) to investigate the familial aggregation of LDL oxidation.
U M, Kujala, M, Ahotupa, T J, Vasankari, J, Kaprio, M J, Tikkanen   +4 more
openaire   +2 more sources

In vitro oxidation of LDL by ozone

Chemistry and Physics of Lipids, 2014
Recent studies suggest that ozone is present in atherosclerotic lesions. Since these lesions are characterized by a dramatic accumulation of low-density lipoprotein (LDL), we aimed to investigate whether ozone is capable of oxidizing LDL, thereby rendering this lipoprotein atherogenic.
Gerd, Hörl, Gerhard, Ledinski, Gerd, Kager, Seth, Hallström, Erwin, Tafeit, Martin, Koestenberger, Günther, Jürgens, Gerhard, Cvirn   +7 more
openaire   +2 more sources

Metabolism of oxidized LDL by macrophages

Current Opinion in Lipidology, 2000
Oxidation products of lipids and proteins are found in atherosclerotic plaque and in macrophage foam cells. Macrophages avidly endocytose in-vitro oxidized LDL and accumulate sterols. What is the evidence that such a process is involved in in-vivo foam cell formation?
W, Jessup, L, Kritharides
openaire   +2 more sources

Oxidation of LDL, Atherogenesis, and Apoptosis

Annals of the New York Academy of Sciences, 2003
Abstract: A plethora of studies in cultured cells have established that oxidized low‐density lipoprotein (oxLDL) may enhance arterial apoptosis that involves both mitochondrial and death receptor pathways (Fas/FasL, TNF receptors I and II), thereby activating caspase cascade and other proteases.
openaire   +3 more sources

Iron and LDL‐oxidation in atherogenesis.

APMIS, 1998
It has been proposed that the development of atherosclerosis may be linked to the size of the body iron stores. The exact role of iron in the initiation and progression of atherogenesis is, however, still unknown. As a result of increasing support for the LDL‐oxidation hypothesis, much additional knowledge about the relation between iron and ...
X M, Yuan, U T, Brunk
openaire   +2 more sources

Inhibition of LDL oxidation by antioxidants

1992
Low density lipoprotein (LDL) consists of about 3000 fatty acids (50% polyunsaturated) and a single molecule apolipoprotein B (500 kDa). The endogenous antioxidants of LDL consist mainly of tocopherols and few carotenoids, which protect the PUFAS against oxidation.
H, Esterbauer, G, Waeg, H, Puhl, M, Dieber-Rotheneder, F, Tatzber   +4 more
openaire   +2 more sources

Role of Oxidized LDL in Atherosclerosis

Annals of the New York Academy of Sciences, 2001
Abstract: A critical event in the early stages of atherosclerosis is the focal accumulation of lipid‐laden foam cells derived from macrophages. In various cholesterol‐fed animal models of atherosclerosis, localized attachment of circulating monocytes to arterial endothelial cells appeared to precede the formation of foam cells.
T, Kita, N, Kume, M, Minami, K, Hayashida, T, Murayama, H, Sano, H, Moriwaki, H, Kataoka, E, Nishi, H, Horiuchi, H, Arai, M, Yokode   +11 more
openaire   +2 more sources

Immunological responses to oxidized LDL

Free Radical Biology and Medicine, 2000
Considerable evidence now points to an important role for the immune system in experimental models of atherosclerosis. We have reviewed the growing body of evidence that oxidation of LDL generates a wide variety of neoself determinants that lead to cellular and humoral immune responses.
S, Hörkkö, C J, Binder, P X, Shaw, M K, Chang, G, Silverman, W, Palinski, J L, Witztum   +6 more
openaire   +2 more sources

Inhibition of LDL Oxidation and Oxidized LDL-induced Cytotoxicity by Dihydropyridine Calcium Antagonists

Pharmaceutical Research, 2000
The antioxidant activity of dihydropyridine calcium channel antagonists was evaluated based on LDL oxidation kinetics, oxidative cell injury associated with reactive species generation, and increases in free intracellular calcium (Ca2+) levels. Interactions with ascorbic acid were studied under conditions representative of LDL oxidation in plasma and ...
A. SEVANIAN, S. SHEN, URSINI, FULVIO
openaire   +3 more sources

Oxidized LDL and Atherogenesis^a

Annals of the New York Academy of Sciences, 1999
Abstract: A brief review of recent findings regarding the role of oxidized low‐density lipoproteins (Ox‐LDL) in atherogenesis. Lipid peroxidation and oxidative damage to LDL make arteries susceptible to chronic inflammation, which is known to cause alterations in arterial gene expression and promote lesion development. Treatment protocols implementing
openaire   +2 more sources