Results 141 to 150 of about 89,126 (347)
Animal Models and Experimental Medicine, EarlyView.Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.Orally administered polystyrene microplastics accumulate in murine tissues and are detected using MALDI‐MSI with TIMS. Lipid profiling reveals decreases in hexosylceramides, sphingomyelins, and ether‐linked phospholipids, indicating altered metabolism.
Karina A. Vargas +5 more
wiley +2 more sources
Oxidized Low-Density Lipoprotein–Dependent Endothelial Arginase II Activation Contributes to Impaired Nitric Oxide Signaling [PDF]
, 2006 Sungwoo Ryoo +8 more
openalex +1 more source
Animal Models and Experimental Medicine, EarlyView.This study presents an integrative multi‐omics framework to uncover the molecular mechanisms and potential biomarkers of chronic thromboembolic pulmonary hypertension (CTEPH). Anthropometric and biochemical data were correlated using canonical correlation analysis, revealing key cardiometabolic associations. Single‐cell RNA sequencing identified immune
Xiaopeng Liu +4 more
wiley +1 more source
Cholesteryl Ester Hydroperoxides Are Biologically Active Components of Minimally Oxidized Low Density Lipoprotein [PDF]
, 2008 Richard Harkewicz +5 more
openalex +1 more source
A high‐fat diet with vitamin D and propylthiouracil produces a pro‐atherogenic phenotype in rats
Animal Models and Experimental Medicine, EarlyView.Male Sprague–Dawley rats received a cholesterol‐rich high‐fat diet supplemented with vitamin D and propylthiouracil for 11 weeks. The model induced dyslipidemia (increased total cholesterol/low‐density lipoprotein, decreased triglycerides), inflammation (increased interleukin‐6 and serum amyloid A), hypercalcemia, and reduced circulating endothelial ...
Angélique Lewies +3 more
wiley +1 more source
Beni-Suef University Journal of Basic and Applied SciencesBackground Atherosclerosis remains a leading cause of cardiovascular morbidity and mortality despite advances in lipid-lowering therapy. The proprotein convertase subtilisin/kexin type 9 protein (PCSK9) was originally characterized for promoting ...
Muhammad A. Desouky +5 more
doaj +1 more source
Annals of Neurology, EarlyView.Objective Lactate is increasingly recognized as an energy substrate, but its relevance to amyotrophic lateral sclerosis (ALS) remains unclear. We examined whether blood lactate is associated with survival and weight loss in ALS. Methods This retrospective study included an Australian exploratory cohort and a Japanese validation cohort with clinical ...
Ryutaro Nakamura +8 more
wiley +1 more source
Effects of Various Levels of Oxidized Oil on Performance, Egg Quality and Some Blood Metabolites in Laying Hens [PDF]
Poultry Science Journal, 2016 The influence of dietary oxidized oil was studied on laying hen performance, egg quality and blood metabolites. Experiment was conducted on 160 laying hens (Hy-Line W-36, 54-61 wk of age) in a completely randomized design with five treatments and four ...
AA Saki +4 more
doaj
Caveolae and caveolin-1 mediate endocytosis and transcytosis of oxidized low density lipoprotein in endothelial cells [PDF]
, 2010 Shaowei Sun +7 more
openalex +1 more source